Center for Personal Dynamic Regulomes
个人动态调节中心
基本信息
- 批准号:10456125
- 负责人:
- 金额:$ 264.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AllelesAutoimmunityAutomobile DrivingBindingBiologicalBiological AssayBiologyBiopsyBiosensorBloodBrainCRISPR interferenceCellsChromatinChromosomesClinicClinicalCommunitiesComplexCoupledDNADNA SequenceDataData SetDiseaseDistantDreamsEffectivenessElementsEncapsulatedEncyclopedia of DNA ElementsEngineeringEnhancersEpigenetic ProcessEpithelialEpitopesEtiologyEventExerciseFoundationsGene Expression RegulationGenerationsGenesGeneticGenetic TranscriptionGenetic VariationGenomeGenomicsGenotypeHeterochromatinHumanHuman GenomeIndividualInterventionInvestigationKnowledgeLaboratoriesLeadLifeLinkLiquid substanceMalignant NeoplasmsMeasurementMethodsModelingModificationMolecularMolecular ConformationMultiomic DataNeurodegenerative DisordersOrganoidsOutcomeOutputPathologyPatientsPersonsProtein IsoformsProteinsRNARegulationRegulator GenesRegulatory ElementResolutionSamplingSchizophreniaSolidSourceSpeedStructureSystemTechnologyThe Cancer Genome AtlasTimeTissuesTrainingTransactUntranslated RNAVariantbasebiological systemscausal variantcell typecircular RNAclinical applicationcomputational platformcomputerized toolsconnectomedisease diagnosisepigenetic variationepigenomicsgenetic variantgenome-widegenomic aberrationshuman datahuman diseasehuman tissueimprovedindividual patientinsightmultiple omicsnew technologynovelpersonalized medicineprecision medicinerisk variantsample archivesample collectionsingle cell technologysingle moleculetranscription factortreatment response
项目摘要
Project Summary
Tens of thousands of human genomes have been sequenced, but the central challenge
is their interpretation. A comprehensive set of regulatory events across a genome—the
regulome—is needed to make full use of genomic information, but is currently out of
reach for most clinical applications and biological systems. The proposed Center will
develop technologies that greatly increase the sensitivity, speed, and
comprehensiveness of understanding genome regulation. We will develop new
technologies to interrogate the transactions between the genome and regulatory factors,
such as proteins and noncoding RNAs from single cells, and integrate variations in DNA
sequences and chromatin states over time and across individuals. Novel molecular
engineering and biosensor strategies are deployed to encapsulate the desired complex
DNA transformations into the probe system, such that the probe system can be directly
used on very small human clinical samples and capture genome-wide information in one
or two steps. These technologies will be applied to clinical samples with genomic
aberrations to exercise their robustness, and reveal for the first time epigenomic
dynamics of human diseases during progression and treatment. These technologies will
be broadly applicable to many biomedical investigations, and the Center will disseminate
the technologies via training and diverse means.
项目摘要
数以万计的人类基因组已被测序,但核心挑战是
是他们的诠释。基因组中的一组全面的调控事件-
调节组-需要充分利用基因组信息,但目前没有
适用于大多数临床应用和生物系统。拟建中心将
开发技术,大大提高灵敏度,速度,
了解基因组调控的全面性。发展新型
询问基因组和调节因子之间的交易的技术,
例如来自单细胞的蛋白质和非编码RNA,以及DNA中的整合变异
序列和染色质状态随时间和个体的变化。新型分子
工程和生物传感器策略被用来封装所需的复合物
将DNA转化到探针系统中,使得探针系统可以直接
用于非常小的人类临床样本,并在一个
或两个步骤。这些技术将应用于具有基因组的临床样品
畸变,以锻炼其鲁棒性,并首次揭示表观基因组
人类疾病进展和治疗过程中的动力学。这些技术将
广泛适用于许多生物医学研究,该中心将传播
通过培训和各种方式来学习技术。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(2)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Howard Y Chang其他文献
Gene regulation in the immune system by long noncoding RNAs
长非编码 RNA 在免疫系统中的基因调控
- DOI:
10.1038/ni.3771 - 发表时间:
2017-08-22 - 期刊:
- 影响因子:27.600
- 作者:
Y Grace Chen;Ansuman T Satpathy;Howard Y Chang - 通讯作者:
Howard Y Chang
Howard Y Chang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Howard Y Chang', 18)}}的其他基金
Ultra-Fast Epigenomic Maps for Monitoring Autoimmunity
用于监测自身免疫的超快速表观基因组图谱
- 批准号:
8732973 - 财政年份:2014
- 资助金额:
$ 264.19万 - 项目类别:
相似海外基金
B cell development, autoimmunity and immune regulation
B 细胞发育、自身免疫和免疫调节
- 批准号:
MR/Y033701/1 - 财政年份:2024
- 资助金额:
$ 264.19万 - 项目类别:
Research Grant
Thymus antibody-secreting cells: major players in autoimmunity.
胸腺抗体分泌细胞:自身免疫的主要参与者。
- 批准号:
502578 - 财政年份:2024
- 资助金额:
$ 264.19万 - 项目类别:
Applying advanced understanding of CTLA-4 function to optimise therapies for autoimmunity
应用对 CTLA-4 功能的深入理解来优化自身免疫疗法
- 批准号:
MR/Y001273/1 - 财政年份:2024
- 资助金额:
$ 264.19万 - 项目类别:
Research Grant
MUC16 (CA125) mutations promote fibrosis and autoimmunity in systemic sclerosis
MUC16 (CA125) 突变促进系统性硬化症的纤维化和自身免疫
- 批准号:
478933 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Operating Grants
Mechanisms of New-Onset Autoimmunity/Longitudinal Immune Systems Analysis (MONA-LISA)
新发自身免疫/纵向免疫系统分析(MONA-LISA)的机制
- 批准号:
10655219 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Development of serologic test for early risk stratification of islet autoimmunity in genetically predisposed T1D individuals
开发用于遗传易感性 T1D 个体胰岛自身免疫早期风险分层的血清学检测
- 批准号:
10760885 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Autoimmunity-Associated B Cells in Lupus Nephritis
狼疮性肾炎中自身免疫相关的 B 细胞
- 批准号:
10582053 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Understanding autoimmunity: Why do B cells sometimes attack our tissues instead of protecting us from infections?
了解自身免疫:为什么 B 细胞有时会攻击我们的组织而不是保护我们免受感染?
- 批准号:
2889164 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Studentship
Heparan sulfate as a platform to boost regulatory T cell suppression of autoimmunity
硫酸乙酰肝素作为增强调节性 T 细胞抑制自身免疫的平台
- 批准号:
490663 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Operating Grants
The interplay of sex hormones and chromosomes dictates pathogenicity in progressive CNS autoimmunity.
性激素和染色体的相互作用决定了进行性中枢神经系统自身免疫的致病性。
- 批准号:
488982 - 财政年份:2023
- 资助金额:
$ 264.19万 - 项目类别:
Operating Grants