Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10473821
• 负责人: ANDREW P LIEBERMAN
• 金额: $ 24.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473821
• 关键词: Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Basic Science; Biological; Biological Markers; Black race; Brain; Clinical; Clinical Data; Clinical Research; Collaborations; Collection; Communities; Country; DNA Library; Data; Databases; Dementia; Diagnostic Services; Disease; Educational Activities; Evaluation; Family Caregiver; Freezing; Future; Goals; Health Professional; Hispanic; Institution; Investigation; Latino; Michigan; Microscopy; Nerve Degeneration; Participant; Pathogenesis; Patients; Physicians; Plasma; Practice Guidelines; Procedures; Reagent; Recruitment Activity; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Serum; Standardization; Technology; Therapeutic; Tissue Banks; Tissues; Training; Universities; Whole Blood; Work; brain dysfunction; brain tissue; cohort; data analysis pipeline; data management; diagnostic criteria; education research; innovation; innovative technologies; neuropathology; next generation; outreach services; profession allied to medicine; translational study

ABSTRACT – CORE D: NEUROPATHOLOGY CORE The Neuropathology Core (NC) will capitalize on the longstanding, actively recruiting University of Michigan (U- M) Brain Bank and more than 35 years of patient clinical characterization by Alzheimer’s disease (AD) researchers to advance the Michigan ADRC's central theme: to identify, understand and modulate the non-β- amyloid factors contributing to brain dysfunction and neurodegeneration in AD and related dementias (ADRD). The overall goal of the NC is to facilitate innovative research into the biological mechanisms of dementia by providing essential reagents, expertise, and access to technologies for investigators at U-M, Michigan State University, and Wayne State University, and to ADRCs and investigators across the country. Studies of ADRD will be facilitated by the integrated efforts of the NC, Clinical Core, Biomarker Core, and Data Management and Statistical Core to collect and properly characterize post-mortem material and associated antemortem biospecimens and clinical data from ADRC participants. The NC will provide postmortem material and other biospecimens to investigators while following the best practice guidelines delineated by the 2014 NIA biospecimen task force for the evaluation, banking and distribution of brain tissue and biospecimens. Leveraging the diverse expertise of NC investigators in neurodegenerative proteinopathies and a high-content automated microscopy shared resource, the NC also will facilitate innovative research into the biological mechanisms of dementia by providing essential reagents, expertise, and access to technologies for investigators. To accomplish these goals, the NC will pursue the following aims: 1) grow and maintain a brain bank with well-characterized frozen and fixed tissue, 2) provide accurate, detailed, and standardized neuropathological evaluation, 3) distribute banked tissue and biospecimens, 4) contribute neuropathologic data to the National Alzheimer’s Coordinating Center (NACC), 5) support researchers studying AD and related dementias by providing access to innovative technologies, and 6) educate trainees about the neuropathologic assessment of dementia. Through these aims, the NC will greatly facilitate basic and translational studies of the dementias, expand the research community actively engaged in this work, and help build new collaborations for future discoveries.

摘要-核心D：神经病理学核心 神经病理学核心（NC）将利用密歇根大学（U-）长期以来积极招募的优势， M）脑库和超过35年的阿尔茨海默病（AD）患者临床特征分析 研究人员推进密歇根州ADRC的中心主题：识别，理解和调节非β- 淀粉样因子导致AD和相关痴呆（ADRD）的脑功能障碍和神经变性。 NC的总体目标是通过以下方式促进对痴呆症生物机制的创新研究 为密歇根州立大学的研究人员提供必要的试剂、专业知识和技术 大学、韦恩州立大学以及全国各地的药物滥用研究中心和调查人员。ADRD研究 将通过NC、临床核心、生物标志物核心和数据管理的综合努力来促进， 统计核心收集和适当表征死后材料和相关的死前 来自ADRC参与者的生物标本和临床数据。NC将提供尸检材料和其他 在遵循2014年NIA规定的最佳实践指南的情况下， 生物标本工作队，负责脑组织和生物标本的评价、储存和分发。 利用NC研究人员在神经退行性蛋白病方面的各种专业知识和高含量的 自动显微镜共享资源，NC还将促进生物学领域的创新研究， 通过提供必要的试剂，专业知识和获得技术， investigators.为了实现这些目标，NC将追求以下目标：1）培养和维持大脑 具有良好表征的冷冻和固定组织的库，2）提供准确、详细和标准化的 神经病理学评价，3）分发库存组织和生物标本，4）提供神经病理学数据 国家阿尔茨海默氏症协调中心（NACC），5）支持研究AD和相关疾病的研究人员 通过提供创新技术，以及6）教育受训者了解神经病理学 痴呆症的评估通过这些目标，NC将大大促进基础和翻译研究， 痴呆症，扩大研究界积极从事这项工作，并帮助建立新的 为未来的发现而合作。