Core G: Neuroimaging Core

核心 G：神经影像核心

• 批准号: 10473835
• 负责人: DOUGLAS C NOLL
• 金额: $ 43万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473835
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-Protein; Autopsy; Basic Science; Biological Markers; Blood Vessels; Clinical; Clinical Markers; Clinical Research; Collaborations; Consult; Consultations; Data; Deposition; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Progression; Early Diagnosis; Education; Educational workshop; Ensure; Functional Magnetic Resonance Imaging; Gold; Health; Hippocampus (Brain); Image; Imaging Device; Instruction; Iron; Laboratories; Lead; Lesion; Link; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Methods; Michigan; Modality; Modeling; Monitor; Myelin; Nerve Degeneration; Participant; Pathology; Peripheral; Physics; Positron-Emission Tomography; Predisposition; Protocols documentation; Research; Research Personnel; Schedule; Scientist; Site; Source; Staging; Standardization; Testing; Tissues; Tracer; Training; Universities; Validation; Water; Work; arterial spin labeling; biomarker validation; data management; design; education research; eligible participant; flexibility; image archival system; image processing; imaging biomarker; longitudinal analysis; meetings; morphometry; multimodality; neuroimaging; neuropathology; next generation; novel; novel marker; rapid growth; recruit; tau Proteins; tool

ABSTRACT – CORE G: NEUROIMAGING CORE The overall objectives of the Neuroimaging Core (NIC) are to provide and integrate state-of-the-art, standardized MRI and PET imaging measures for Michigan Alzheimer’s Disease Research Center (MADRC) participants, work with both internal and external stakeholders to evaluate and deploy novel imaging biomarkers, and engage in collaborations, consultation and educational efforts to maximize the utility of these measures. The NIC will acquire longitudinal structural and functional MRI on all eligible MADRC participants using consistent imaging devices and providing flexible scheduling to assist in recruiting non-local participants. The NIC will also provide access to tau and amyloid PET protocols and quantitation. The NIC will provide standardized image processing (e.g. morphometry, connectivity, lesion measures) and, in coordination with the Data Management and Statistical Core (DMSC), maintain an internal archive of imaging data that can be accessed by all MADRC researchers. The NIC will also study and validate novel imaging biomarkers using MRI, including myelin-water fraction (MWF), iron accumulation using quantitative susceptibility mapping, microstructural modeling using diffusion MRI, hippocampus subfield volumetry, and vascular pathology. The NIC will collaborate with the Clinical Core to coordinate and facilitate imaging of MADRC participants, and work with the DMSC to provide access to imaging data locally and nationally, including summary measures from neuroimaging data, and collaborate with the Biomarker Core on biomarker validation. The NIC will consult with new and existing investigators on the design of neuroimaging studies, making use of standardized imaging protocols whenever possible. We will also provide consultation on novel imaging biomarkers as they are deployed. Finally, we will work with the Research Education Component to provide didactic and hands-on training related to MRI and PET acquisition and analyses. Through these efforts, the NIC will provide high quality non-invasive neuroimaging data to facilitate early diagnosis, prediction, and monitoring of disease progression, providing a rich source of data beyond traditional clinical markers.

摘要-核心G：神经成像核心 神经影像学核心（NIC）的总体目标是提供和整合最先进的， 密歇根阿尔茨海默病研究中心（MADRC）的标准化MRI和PET成像措施 参与者与内部和外部利益相关者合作，评估和部署新型成像 生物标志物，并参与合作，咨询和教育工作，以最大限度地利用这些 措施NIC将对所有符合条件的MADRC参与者进行纵向结构和功能MRI检查 使用一致的成像设备，并提供灵活的时间安排，以协助招募非本地参与者。 NIC还将提供tau和淀粉样蛋白PET方案和定量。NIC将提供 标准化的图像处理（例如，形态测量、连接性、病变测量），并与 数据管理和统计核心（DMSC），维护成像数据的内部存档， 所有MADRC研究人员都可以访问。NIC还将研究和验证新的成像生物标志物， MRI，包括髓磷脂-水分数（MWF），使用定量磁化率绘图的铁蓄积， 使用扩散MRI、海马子域体积测定法和血管病理学进行显微结构建模。的 NIC将与临床中心合作，协调和促进MADRC参与者的成像，并 与DMSC合作，提供当地和全国的成像数据，包括从 神经成像数据，并与生物标志物核心合作进行生物标志物验证。NIC将咨询 新的和现有的研究人员对神经影像学研究的设计，利用标准化的成像 只要有可能，协议。我们还将提供新的成像生物标志物的咨询，因为他们是 部署。最后，我们将与研究教育组件合作，提供教学和实践 与MRI和PET采集和分析相关的培训。通过这些努力，NIC将提供高 高质量的非侵入性神经影像学数据，有助于疾病的早期诊断、预测和监测 进展，提供了超越传统临床标志物的丰富数据来源。