Core G: Neuroimaging Core

核心 G：神经影像核心

• 批准号: 10261115
• 负责人: DOUGLAS C NOLL
• 金额: $ 43.62万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261115
• 关键词: Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-Protein; Autopsy; Basic Science; Biological Markers; Blood Vessels; Clinical; Clinical Markers; Clinical Research; Collaborations; Consult; Consultations; Data; Deposition; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease Progression; Early Diagnosis; Education; Educational workshop; Ensure; Functional Magnetic Resonance Imaging; Gold; Health; Hippocampus (Brain); Image; Imaging Device; Instruction; Iron; Laboratories; Lead; Lesion; Link; Longitudinal cohort; Magnetic Resonance Imaging; Measures; Methods; Michigan; Modality; Modeling; Monitor; Myelin; Nerve Degeneration; Participant; Pathology; Peripheral; Physics; Positron-Emission Tomography; Predisposition; Protocols documentation; Research; Research Personnel; Schedule; Scientist; Site; Source; Spin Labels; Staging; Standardization; Structure; Testing; Tissues; Tracer; Training; Universities; Validation; Water; Work; biomarker validation; data management; design; education research; eligible participant; flexibility; image archival system; image processing; imaging biomarker; longitudinal analysis; meetings; morphometry; multimodality; neuroimaging; neuropathology; next generation; novel; novel marker; rapid growth; recruit; tau Proteins; tool

ABSTRACT – CORE G: NEUROIMAGING CORE The overall objectives of the Neuroimaging Core (NIC) are to provide and integrate state-of-the-art, standardized MRI and PET imaging measures for Michigan Alzheimer’s Disease Research Center (MADRC) participants, work with both internal and external stakeholders to evaluate and deploy novel imaging biomarkers, and engage in collaborations, consultation and educational efforts to maximize the utility of these measures. The NIC will acquire longitudinal structural and functional MRI on all eligible MADRC participants using consistent imaging devices and providing flexible scheduling to assist in recruiting non-local participants. The NIC will also provide access to tau and amyloid PET protocols and quantitation. The NIC will provide standardized image processing (e.g. morphometry, connectivity, lesion measures) and, in coordination with the Data Management and Statistical Core (DMSC), maintain an internal archive of imaging data that can be accessed by all MADRC researchers. The NIC will also study and validate novel imaging biomarkers using MRI, including myelin-water fraction (MWF), iron accumulation using quantitative susceptibility mapping, microstructural modeling using diffusion MRI, hippocampus subfield volumetry, and vascular pathology. The NIC will collaborate with the Clinical Core to coordinate and facilitate imaging of MADRC participants, and work with the DMSC to provide access to imaging data locally and nationally, including summary measures from neuroimaging data, and collaborate with the Biomarker Core on biomarker validation. The NIC will consult with new and existing investigators on the design of neuroimaging studies, making use of standardized imaging protocols whenever possible. We will also provide consultation on novel imaging biomarkers as they are deployed. Finally, we will work with the Research Education Component to provide didactic and hands-on training related to MRI and PET acquisition and analyses. Through these efforts, the NIC will provide high quality non-invasive neuroimaging data to facilitate early diagnosis, prediction, and monitoring of disease progression, providing a rich source of data beyond traditional clinical markers.

抽象核心G：神经影像核心 神经成像核心(NIC)的总体目标是提供和集成最先进的、 密歇根阿尔茨海默病研究中心(MADRC)的标准化MRI和PET成像方法 参与者，与内部和外部利益相关者合作，评估和部署新的成像 生物标志物，并参与合作、咨询和教育努力，以最大限度地利用这些 措施。NIC将对所有符合条件的MADRC参与者进行纵向结构和功能磁共振成像 使用一致的成像设备并提供灵活的日程安排，以协助招募非本地参与者。 NIC还将提供tau和淀粉样蛋白PET方案和定量的访问。网卡将提供 标准化图像处理(例如，形态测量、连通性、病变测量)，并与 数据管理和统计核心(DMSc)，维护成像数据的内部归档 所有MADRC研究人员都可以访问。NIC还将研究和验证新的成像生物标志物 磁共振成像，包括髓鞘水分数(MWF)，使用定量磁化率图的铁蓄积， 使用弥散磁共振成像、海马子区体积测量和血管病理学的微观结构建模。这个 NIC将与临床核心合作，协调和促进MADRC参与者的成像，并开展工作 与DMSC合作，提供对当地和全国成像数据的访问，包括来自 神经成像数据，并与Biomarker Core合作进行生物标记物验证。网络接口卡将咨询 利用标准化成像设计神经成像研究的新的和现有的研究人员 只要有可能，协议就会生效。我们还将就新的成像生物标记物提供咨询 已部署。最后，我们将与研究教育组件合作，提供教学和实践 与核磁共振和正电子发射计算机断层扫描采集和分析相关的培训。通过这些努力，网卡将提供更高的 高质量的非侵入性神经成像数据，有助于疾病的早期诊断、预测和监测 进展，提供了传统临床标记物之外的丰富数据来源。