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MRI Parallel Excitation for Neuroimaging Applications

用于神经影像应用的 MRI 并行激励

基本信息

批准号：
8207898
负责人：
DOUGLAS C NOLL
金额：
$ 59.89万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8207898
关键词：
Address Air Alcohols Amplifiers Automobile Driving Biomedical Engineering Blood Brain Brain Part Brain Stem Brain region Clinical Deposition Detection Development Disease Effectiveness Epilepsy Functional Imaging Functional Magnetic Resonance Imaging Goals Hyperactive behavior Image Imaging Device Imaging technology Inferior Investigation Lead Leg Magnetic Resonance Imaging Magnetism Medial Methods Michigan Monitor Morphologic artifacts Neurodegenerative Disorders Obsessive-Compulsive Disorder Patients Pattern Performance Physiologic pulse Play Population Predisposition Process Protocols documentation Research Research Personnel Resolution Role Signal Transduction Simulate Sinus Slice Software Validation Source Speed Structure Substance abuse problem System Systems Integration Techniques Technology Temporal Lobe Testing Texas Time Universities absorption brain tissue cost design design and construction flexibility frontal lobe frontal sinus improved interest magnetic field multidisciplinary neuroimaging neuropsychiatry new technology novel novel strategies patient population prevent programs radiofrequency simulation technology development technology validation voltage

项目摘要

A Bioengineering Research Partnership (PAR-06-459) is proposed for the development of parallel excitation technology to improve functional magnetic resonance imaging (fMRI) studies in the inferior frontal cortex. This project is motivated by the need to eliminate large signal voids and image distortions caused by magnetic susceptibility differences between brain tissue and air in the nasal sinuses. These artifacts are ubiquitous in fMRI, especially for many inferior brain structures including the orbitofrontal cortex (OFC), inferior and medial temporal lobes, and brain stem structures. These parts of the brain have been implicated in neurodegenerative disorders, epilepsy, psychiatric conditions and alcohol/substance abuse disorders. Many current techniques to remove these distortions have a large cost in terms of temporal resolution or sensitivity for detection of activation. Our group has pioneered methods for reducing these artifacts, including multidimensional selective excitation, a technique that is promising, but is currently limited in the degree of correction and by the long duration of the excitation pulses. Parallel excitation is a new technology that will allow for greater flexibility in exciting specific patterns or more uniform patterns in MRI through the use of multiple independent excitation channels. For multidimensional excitation patterns, such as those used to eliminate the signal-loss artifacts in inferior brain regions in fMRI, parallel excitation should allow shorter pulses and offer more complete correction. This project is uniquely multidisciplinary in that it involves advances in parallel excitation pulse design, parallel excitation hardware, system integration, and application to studies of patients. This project will be lead by a multidisciplinary group of investigators: the Lead Investigators for this project are Douglas Noll (PI;System Integration and Software, Validation), Jeffrey Fessler (Pulse Optimization), and Stephen Taylor (Patient Studies); all from Univ. of Michigan and Steven Wright (Co-Pi; Hardware, System Integration) from Texas A&M University. This project offers novel optimization strategies to parallel excitation pulse design, unique current source technologies for driving the parallel transmit array, and important scientific investigation into the functioning of the OFC. Together, these approaches lead to valuable new methods for functional MRI that are capable of probing inferior brain structures with sensitivity equal to other structures, which will aid in the study of a variety of neuropsychiatric disorders. The parallel excitation technology developed here will also advance the general state of MRI technology for correction of excitation inhomogeneity at high magnetic fields and for many other application of multidimensional excitation in MRI.

提出了一个生物工程研究伙伴关系(PAR-06-459)，用于发展平行激励改进额叶下部皮质功能磁共振成像(FMRI)研究的技术。该项目的动机是需要消除大的信号空洞和图像失真脑组织和鼻窦空气之间的磁化率差异。这些文物是在fMRI中普遍存在，特别是许多下部大脑结构，包括眼眶额叶皮质(OFC)，下、内侧颞叶和脑干结构。大脑的这些部分已经被牵连到在神经退行性疾病、癫痫、精神疾病和酒精/药物滥用障碍中。许多当前用于消除这些失真的技术在时间分辨率或检测激活的灵敏度。我们团队开创了减少这些文物的方法，包括多维选择性激发，这是一种很有前途的技术，但目前仅限于校正程度和激励脉冲的长持续时间。并行激励是一种新技术，它将允许在激励特定模式或更多模式时具有更大的灵活性通过使用多个独立的激发通道，在磁共振成像中形成统一的模式。对于多维激发模式，例如用于消除fMRI中下部大脑区域的信号损失伪影的模式，平行激励应允许更短的脉冲，并提供更完整的校正。这个项目是独一无二的它涉及并行励磁脉冲设计、并行励磁硬件、系统集成，以及在患者研究中的应用。这个项目将由一个多学科的调查组：该项目的首席调查员是Douglas Noll(PI；系统集成和软件，验证)、Jeffrey Fessler(脉冲优化)和Stephen Taylor(患者研究)；大学。密歇根大学的史蒂文·赖特和德克萨斯A&M大学的史蒂文·赖特(硬件、系统集成)。该方案为并联励磁脉冲设计提供了新颖的优化策略，具有独特的电流源驱动并行发射阵列的技术，以及对其功能的重要科学调查 OFC的成员。总之，这些方法为功能磁共振带来了有价值的新方法，以与其他结构相同的灵敏度探测下部大脑结构，这将有助于对各种神经精神障碍。这里开发的并联励磁技术也将得到进步强磁场下激励不均匀性的MRI校正技术概况多维激发在磁共振成像中的许多其他应用。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

An eight-channel T/R head coil for parallel transmit MRI at 3T using ultra-low output impedance amplifiers.

八通道 T/R 头部线圈，用于使用超低输出阻抗放大器以 3T 并行传输 MRI。

DOI：
10.1016/j.jmr.2014.06.019
发表时间：
2014
期刊：
Journal of magnetic resonance (San Diego, Calif. : 1997)
影响因子：
0
作者：
Moody,KatherineLynn;Hollingsworth,NealA;Zhao,Feng;Nielsen,Jon-Fredrik;Noll,DouglasC;Wright,StevenM;McDougall,MaryPreston
通讯作者：
McDougall,MaryPreston

Joint Design of Excitation k-Space Trajectory and RF Pulse for Small-Tip 3D Tailored Excitation in MRI.