Michigan Alzheimer's Disease Research Center

摘要--总体 四年前，密歇根ADRC(MADRC)作为一个新的财团成立，将三大 密歇根研究型大学：密歇根大学、密歇根州立大学和韦恩州立大学 大学。为密歇根州全州服务，新的MADRC在广泛的领域取得了里程碑成就 强调一个中心主题的活动和研究：识别、理解和治疗无数非β- 淀粉样蛋白在阿尔茨海默病和相关痴呆患者脑功能障碍和变性中的作用 (ADRD)。在NIA的持续支持下，MADRC建议保持这一中心主题，因为它捕捉到了 我们痴呆症科学家的不同专业知识，揭示了ADRD的异质性，并反映了 参加MADRC赞助的研究的不同种族的研究参与者的经验。至 为了实现其目标，MADRC有四个主要目标：1)催化和执行最高级别的研究 对ADRD的影响；2)促进区域努力全面了解、诊断和治疗痴呆症 通过协作的科学和外联努力；3)提供保健培训和研究机会 通过创新的教育和指导计划，在ADRD护理专业人员、科学家和学生； 以及4)与其他ADRC、NACC、NCRAD和其他多中心合作，在 为这些破坏性疾病开发新的诊断和治疗干预措施。综合努力 七个核心，包括新的神经成像和Biomarker核心，将支持广泛的基础、临床、 翻译和健康差异研究将该领域推向：提高对疾病的理解 机制；更精确地识别整个痴呆症谱系的疾病；开发新的 生物标志物；增加对黑人健康差异的基础的了解 美国人；非药物疗法的发展；以及疾病的识别和修改 风险。研究教育部分(REC)将作为创新培训的核心 跨越所有核心的机遇，以及一项新的领导人倡议将支持和促进不同的 痴呆症研究的下一代领导者。受益于这三家公司的杰出资源 大学和强大的多机构支持，MADRC准备做出新的发现，教育 公众，并培训下一代领导人，因为我们寻求实现国家 阿尔茨海默氏症项目法案。

ABSTRACT – OVERALL Four years ago the Michigan ADRC (MADRC) was established as a new consortium linking the three major research universities in Michigan: University of Michigan, Michigan State University, and Wayne State University. Serving the entire state of Michigan, the new MADRC achieved its milestones in wide-ranging activities and research that emphasized a central theme: to identify, understand and treat the myriad non-β- amyloid contributions to brain dysfunction and degeneration in Alzheimer’s disease and related dementias (ADRD). With continued NIA support, the MADRC proposes to maintain this central theme because it captures the diverse expertise of our dementia scientists, sheds light on ADRD heterogeneity, and reflects the experience of the racially diverse pool of research participants engaged in MADRC-sponsored studies. To achieve its objectives, the MADRC has four major aims: 1) Catalyze and perform research of the highest impact in ADRD; 2) Promote regional efforts to understand, diagnose and treat the full spectrum of dementias through collaborative scientific and outreach efforts; 3) Provide training and research opportunities for health care professionals, scientists, and students in ADRD through innovative educational and mentoring programs; and 4) Collaborate with other ADRCs, the NACC, NCRAD, and other multi-center efforts to lead the field in developing new diagnostic and therapeutic interventions for these devastating diseases. The integrated efforts of seven Cores, including new Neuroimaging and Biomarker cores, will support a wide range of basic, clinical, translational and health disparities research advancing the field toward: improved understanding of disease mechanisms; more precise disease identification across the dementia spectrum; development of novel biomarkers; increased knowledge of the basis for health disparities that disproportionately affect Black Americans; development of non-pharmacological therapies; and the identification and modification of disease risks. The Research Education Component (REC) will serve as the centerpiece of innovative training opportunities spanning all the Cores, and a new Leaders Initiative will support and promote a diverse group of next-generation leaders in dementia research. Benefitting from the outstanding resources of all three universities and strong multi-institutional support, the MADRC is poised to make new discoveries, educate the public, and train next-generation leaders as we seek to achieve the milestones set forth in the National Alzheimer’s Project Act.