South Texas Alzheimer’s Disease Center Population Neuroscience

摘要-种群神经科学核心 南得克萨斯州阿尔茨海默氏症中心(STAC)的人口神经科学核心(PNC)旨在推动我们的 了解导致阿尔茨海默病和相关痴呆的生命过程因素， 特别是在研究不足的墨西哥裔美国人中，他们面临着更高的风险 疾病。为了实现这一目标，我们的团队将进行前沿的流行病学和神经科学研究 监测痴呆症中健康差距的流行情况和发病趋势，确定生命过程中的风险和 促进痴呆症的保护性因素，为风险预测确定合适和经济有效的生物标记物， 以及为墨西哥裔美国人的认知评估开发文化和语言上合适的工具 来自南得克萨斯州。PNC拥有来自现有纵向人口队列的特殊资源， 新的研究集中在墨西哥裔美国人身上，具有深刻的表型，并建立了国家和国际 合作。PNC的目标是进一步缩小墨西哥裔美国人在 流行病学研究。这将通过创建一个PNC共享资源来实现，在这种情况下， 痴呆症研究中UDS和其他标准的数据将与其他ADRC和科学研究中心共享 社区。此设置允许PNC为临床和 神经病理核心以及其他ADRC。最后，我们将培训医学博士、博士和其他专业人员 人口神经科学，发展定量和定性研究方法的技能，利用当地 和国家级数据。PNC将与所有STAC核心密切合作，制定这些目标。 总而言之，PNC的战略定位是成为墨西哥宝贵数据的全国资源 居住在德克萨斯州南部的美国拉美裔美国人，也是以阿尔茨海默氏症和 相关痴呆症的研究。我们与其他STAC核心完全集成，以提供知识、数据、 为整个中心以及更广泛的ADRC和科学研究机构的调查人员提供服务、工具和培训 社区。

ABSTRACT – Population Neuroscience Core The Population Neuroscience Core (PNC) of the South Texas Alzheimer’s Center (STAC) aims to advance our understanding of the life course factors contributing to Alzheimer’s Disease and Related Dementias, particularly in the understudied population of Mexican American Hispanic, who face an increased risk of the disease. To achieve this goal, our team will conduct cutting-edge epidemiological and neuroscience research to monitor the prevalence and incidence trends of health disparities in dementia, identify life-course risk and protective factors contributing to dementia, identify suitable and cost-effective biomarkers for risk prediction, and the develop culturally and linguistically appropriate tools for cognitive assessment in Mexican Americans from South Texas. The PNC has exceptional resources from existing longitudinal population-based cohorts, new studies focusing on Mexican Americans with deep phenotyping, and established national and international collaborations. The PNC aims to additionally close the gap of representation of Mexican Americans in epidemiological research. This will be achieved by the creation of a PNC sharing resource, where harmonized data to UDS and other standards in dementia research will be shared with other ADRCs and the scientific community. This setting allows the PNC to provide cognitively healthy controls for the Clinical and Neuropathological Cores as well as other ADRCs. Finally, we will train MDs, PhDs, and other professionals in population neuroscience, to develop skills in quantitative and qualitative research methods by leveraging local and national level data. The PNC will develop these aims in close collaboration with all STAC Cores. In summary, the PNC strategically positioned to be a national resource of valuable data from Mexican American Hispanics living in South Texas, and an asset to collaborative research centered on Alzheimer’s and related dementias research. We are fully integrated with the other STAC Cores to provide knowledge, data, services, tools, and training to investigators across the Center, as well as the broader ADRC and scientific community.