South Texas Alzheimer’s Disease Center Population Neuroscience

南德克萨斯阿尔茨海默病中心人口神经科学

• 批准号: 10472656
• 负责人: Claudia L Satizabal
• 金额: $ 12.38万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10472656
• 关键词: Address; Agreement; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavioral; Bioinformatics; Biological Markers; Biology; Blood; Brain imaging; Chemicals; Clinical; Cognitive; Collaborations; Communities; Consultations; Data; Dementia; Diabetes Mellitus; Disease; Doctor of Philosophy; Etiology; Face; Genome; Genomics; Goals; Health trends; Hispanic Americans; Hispanic Populations; Image; Impaired cognition; Incidence; International; Knowledge; Life Cycle Stages; Life Style; Linguistics; Liquid substance; Magnetic Resonance Imaging; Methods; Mexican Americans; Monitor; Neurosciences; Neurosciences Research; Phenotype; Population; Population Research; Population Study; Positioning Attribute; Positron-Emission Tomography; Prevalence; Preventive measure; Process; Proteome; Protocols documentation; Public Health; Qualitative Research; Recommendation; Reduce health disparities; Research; Research Methodology; Research Personnel; Resource Sharing; Resources; Risk Factors; Role; Services; Source; South Texas; Training; aging brain; cardiovascular risk factor; cognitive testing; cohort; cost effective; critical period; data harmonization; data integration; data management; data resource; data sharing; disorder risk; education research; epidemiology study; epigenome; ethnic minority population; health disparity; high risk; hispanic community; improved; innovation; insight; lipidome; metabolome; microbiome; modifiable risk; novel; population based; precision medicine; prevent; protective factors; psychosocial; racial minority; resilience; risk prediction; skills; statistics; tool; transcriptome; wearable device

ABSTRACT – Population Neuroscience Core The Population Neuroscience Core (PNC) of the South Texas Alzheimer’s Center (STAC) aims to advance our understanding of the life course factors contributing to Alzheimer’s Disease and Related Dementias, particularly in the understudied population of Mexican American Hispanic, who face an increased risk of the disease. To achieve this goal, our team will conduct cutting-edge epidemiological and neuroscience research to monitor the prevalence and incidence trends of health disparities in dementia, identify life-course risk and protective factors contributing to dementia, identify suitable and cost-effective biomarkers for risk prediction, and the develop culturally and linguistically appropriate tools for cognitive assessment in Mexican Americans from South Texas. The PNC has exceptional resources from existing longitudinal population-based cohorts, new studies focusing on Mexican Americans with deep phenotyping, and established national and international collaborations. The PNC aims to additionally close the gap of representation of Mexican Americans in epidemiological research. This will be achieved by the creation of a PNC sharing resource, where harmonized data to UDS and other standards in dementia research will be shared with other ADRCs and the scientific community. This setting allows the PNC to provide cognitively healthy controls for the Clinical and Neuropathological Cores as well as other ADRCs. Finally, we will train MDs, PhDs, and other professionals in population neuroscience, to develop skills in quantitative and qualitative research methods by leveraging local and national level data. The PNC will develop these aims in close collaboration with all STAC Cores. In summary, the PNC strategically positioned to be a national resource of valuable data from Mexican American Hispanics living in South Texas, and an asset to collaborative research centered on Alzheimer’s and related dementias research. We are fully integrated with the other STAC Cores to provide knowledge, data, services, tools, and training to investigators across the Center, as well as the broader ADRC and scientific community.

摘要 – 人口神经科学核心 南德克萨斯阿尔茨海默病中心 (STAC) 的群体神经科学核心 (PNC) 旨在推进我们的 了解导致阿尔茨海默病和相关痴呆症的生命历程因素， 特别是在墨西哥裔美国西班牙裔的研究不足的人群中，他们面临着更大的风险 疾病。为了实现这一目标，我们的团队将进行前沿的流行病学和神经科学研究 监测痴呆症健康差异的患病率和发病率趋势，识别生命全程风险并 导致痴呆症的保护因素，确定合适且具有成本效益的生物标志物进行风险预测， 并开发适合墨西哥裔美国人认知评估的文化和语言工具 来自德克萨斯州南部。 PNC 拥有来自现有纵向人群的特殊资源， 新的研究重点关注具有深层表型的墨西哥裔美国人，并建立了国家和国际 合作。 PNC 的目标是进一步缩小墨西哥裔美国人在选举中的代表性差距 流行病学研究。这将通过创建 PNC 共享资源来实现，其中协调一致 UDS 和痴呆症研究其他标准的数据将与其他 ADRC 和科学界共享 社区。此设置允许 PNC 为临床和临床医生提供认知健康的控制。 神经病理学核心以及其他 ADRC。最后，我们将培训医学博士、博士和其他专业人士 人口神经科学，通过利用当地的资源来发展定量和定性研究方法的技能 和国家级数据。 PNC 将与所有 STAC 核心密切合作来制定这些目标。 总之，PNC 的战略定位是成为墨西哥有价值数据的国家资源 居住在德克萨斯州南部的美国西班牙裔，是以阿尔茨海默病和阿尔茨海默病为中心的合作研究的资产 相关痴呆症研究。我们与其他 STAC 核心完全集成，提供知识、数据、 为整个中心以及更广泛的 ADRC 和科学界的研究人员提供服务、工具和培训 社区。