The San Antonio Heart and Mind Study

圣安东尼奥心灵研究

• 批准号: 10670630
• 负责人: Claudia L Satizabal
• 金额: $ 217.32万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670630
• 关键词: Acceleration; Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Atrophic; Attention; Biological Markers; Blood; Brain; Cardiometabolic Disease; Cardiovascular Diseases; Cessation of life; Chronic Disease; Clinical; Clinical Research; Cognition; Cognitive; Cognitive aging; Consensus; Data; Dementia; Diabetes Mellitus; Diffusion Magnetic Resonance Imaging; Disease; Disease Outcome; Disparity; Early identification; Educational Status; Elderly; Enrollment; Epidemiology; Ethnic Origin; Ethnic Population; Etiology; Genotype; Glial Fibrillary Acidic Protein; Goals; Grant; Health Policy; Heart; High Prevalence; Hippocampus; Hispanic; Hispanic Populations; Impaired cognition; Income; Language; Life Cycle Stages; Link; Liquid substance; Longitudinal Studies; Measurement; Measures; Memory; Mexican Americans; Microvascular Dysfunction; Mind; Minority Groups; Modeling; Modification; Neighborhoods; Nerve Degeneration; Neurologic; Neuropsychology; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Participant; Pathologic; Pattern; Phenotype; Population; Population Study; Positron-Emission Tomography; Preventive; Process; Random Allocation; Records; Research; Risk Factors; Role; Shapes; Standardization; Structure; Survivors; Talents; Texas; Therapeutic; Underserved Population; United States; Update; Visuospatial; White Matter Hyperintensity; Work; aged; aging population; apolipoprotein E-4; brain magnetic resonance imaging; cardiometabolic risk; cardiometabolism; cognitive function; cohort; disability; endophenotype; ethnic difference; ethnic disparity; experience; follow-up; functional status; glucose metabolism; health determinants; human old age (65+); imaging biomarker; indexing; lifetime risk; longitudinal dataset; middle age; mild cognitive impairment; mortality; multidisciplinary; neuropathology; novel; pre-clinical; prevent; programs; protein TDP-43; psychosocial; recruit; sex; social culture; sociocultural determinant; success; tau Proteins; tool; trend; uptake; white matter

ABSTRACT Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) disproportionately affect minoritized populations. Compared to non-Hispanic Whites, older Hispanic adults in the United States are estimated to have a 50% increased risk of AD and are projected to bear the largest relative increase in AD/ADRD cases by 2060. Mexican Americans not only represent the largest segment of Hispanics in the United States, but they also experience a high burden of cardiometabolic diseases, which has the potential to increase AD/ADRD disparities over the next decades. However, Hispanics are underrepresented in epidemiological settings and more research is needed on this ethnic group to identify the factors contributing to AD/ADRD disparities. In this project, we propose to re-establish an epidemiological cohort initiated in 1979 to study ethnic differences in diabetes and cardiovascular disease. The San Antonio Heart Study enrolled 5,158 Mexican American and non-Hispanic White adults from socioculturally diverse neighborhoods in San Antonio, Texas. Through this grant, survivors will be invited to a new study focused on cognitive aging and AD/ADRD: The San Antonio Heart and Mind Study (SAHMS). We will perform comprehensive assessments for cognitive function, brain MRI, amyloid and tau PET, the measurement of blood- and CSF-based biomarkers, cardiometabolic disease, psychosocial attributes, and sociocultural factors. Participants will also be invited to our brain donation program for further neuropathological characterization. By leveraging the rich set of longitudinal data obtained four decades ago and newly collected information through this grant, we have an ideal setting to better understand the role of midlife and late-life factors contributing to AD/ADRD disparities in Mexican American older adults. Our talented multidisciplinary team offers complementary expertise for the success of this project. Results from our study have the potential to inform health policies aiming to prevent and delay AD/ADRD over the next decades, especially in the underserved population of Mexican Americans.

抽象的 阿尔茨海默氏病（AD）和与AD相关的痴呆症（AD/ADRD）不成比例地影响少数 人群。与非西班牙裔白人相比，美国较老的西班牙裔成年人估计有 到2060年，AD的风险增加了50％，预计将使AD/ADRD病例的相对增加最大。 墨西哥裔美国人不仅代表了美国最大的西班牙裔人，而且还代表 经历高燃烧心脏代谢性疾病，这有可能增加AD/ADRD差异 在接下来的几十年中。但是，在流行病学环境和更多研究中，西班牙裔人数不足 这个族裔需要确定导致广告/ADRD差异的因素。在这个项目中，我们 重新建立一个流行病学队列的提议于1979年启动，以研究糖尿病的种族差异 心血管疾病。圣安东尼奥心脏研究注册了5,158墨西哥裔美国人和非西班牙裔白色 来自得克萨斯州圣安东尼奥市社会多元化社区的成年人。通过这笔赠款，幸存者将 邀请一项针对认知衰老和广告/ADRD的新研究：圣安东尼奥心灵研究 （SAHMS）。我们将对认知功能进行全面评估，脑MRI，淀粉样蛋白和Tau PET， 基于血液和CSF的生物标志物，心脏代谢疾病，社会心理属性以及 社会文化因素。还将邀请参与者参加我们的大脑捐赠计划，以进行进一步的神经病理学 表征。通过利用四十年前获得的丰富的纵向数据和新收集 通过这笔赠款的信息，我们有一个理想的环境，可以更好地了解中年和后期因素的作用 在墨西哥裔美国老年人中导致广告/ADRD差异。我们才华横溢的多学科团队提供 完全专业知识为该项目的成功提供了专业知识。我们研究的结果有可能告知 卫生政策旨在预防和延迟接下来的几十年，尤其是在服务不足的情况下 墨西哥裔美国人的人口。