The San Antonio Heart and Mind Study

圣安东尼奥心灵研究

• 批准号: 10670630
• 负责人: Claudia L Satizabal
• 金额: $ 217.32万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670630
• 关键词: Acceleration; Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Atrophic; Attention; Biological Markers; Blood; Brain; Cardiometabolic Disease; Cardiovascular Diseases; Cessation of life; Chronic Disease; Clinical; Clinical Research; Cognition; Cognitive; Cognitive aging; Consensus; Data; Dementia; Diabetes Mellitus; Diffusion Magnetic Resonance Imaging; Disease; Disease Outcome; Disparity; Early identification; Educational Status; Elderly; Enrollment; Epidemiology; Ethnic Origin; Ethnic Population; Etiology; Genotype; Glial Fibrillary Acidic Protein; Goals; Grant; Health Policy; Heart; High Prevalence; Hippocampus; Hispanic; Hispanic Populations; Impaired cognition; Income; Language; Life Cycle Stages; Link; Liquid substance; Longitudinal Studies; Measurement; Measures; Memory; Mexican Americans; Microvascular Dysfunction; Mind; Minority Groups; Modeling; Modification; Neighborhoods; Nerve Degeneration; Neurologic; Neuropsychology; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Outcome; Participant; Pathologic; Pattern; Phenotype; Population; Population Study; Positron-Emission Tomography; Preventive; Process; Random Allocation; Records; Research; Risk Factors; Role; Shapes; Standardization; Structure; Survivors; Talents; Texas; Therapeutic; Underserved Population; United States; Update; Visuospatial; White Matter Hyperintensity; Work; aged; aging population; apolipoprotein E-4; brain magnetic resonance imaging; cardiometabolic risk; cardiometabolism; cognitive function; cohort; disability; endophenotype; ethnic difference; ethnic disparity; experience; follow-up; functional status; glucose metabolism; health determinants; human old age (65+); imaging biomarker; indexing; lifetime risk; longitudinal dataset; middle age; mild cognitive impairment; mortality; multidisciplinary; neuropathology; novel; pre-clinical; prevent; programs; protein TDP-43; psychosocial; recruit; sex; social culture; sociocultural determinant; success; tau Proteins; tool; trend; uptake; white matter

ABSTRACT Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) disproportionately affect minoritized populations. Compared to non-Hispanic Whites, older Hispanic adults in the United States are estimated to have a 50% increased risk of AD and are projected to bear the largest relative increase in AD/ADRD cases by 2060. Mexican Americans not only represent the largest segment of Hispanics in the United States, but they also experience a high burden of cardiometabolic diseases, which has the potential to increase AD/ADRD disparities over the next decades. However, Hispanics are underrepresented in epidemiological settings and more research is needed on this ethnic group to identify the factors contributing to AD/ADRD disparities. In this project, we propose to re-establish an epidemiological cohort initiated in 1979 to study ethnic differences in diabetes and cardiovascular disease. The San Antonio Heart Study enrolled 5,158 Mexican American and non-Hispanic White adults from socioculturally diverse neighborhoods in San Antonio, Texas. Through this grant, survivors will be invited to a new study focused on cognitive aging and AD/ADRD: The San Antonio Heart and Mind Study (SAHMS). We will perform comprehensive assessments for cognitive function, brain MRI, amyloid and tau PET, the measurement of blood- and CSF-based biomarkers, cardiometabolic disease, psychosocial attributes, and sociocultural factors. Participants will also be invited to our brain donation program for further neuropathological characterization. By leveraging the rich set of longitudinal data obtained four decades ago and newly collected information through this grant, we have an ideal setting to better understand the role of midlife and late-life factors contributing to AD/ADRD disparities in Mexican American older adults. Our talented multidisciplinary team offers complementary expertise for the success of this project. Results from our study have the potential to inform health policies aiming to prevent and delay AD/ADRD over the next decades, especially in the underserved population of Mexican Americans.

摘要