South Texas Alzheimer’s Disease Center Population Neuroscience

南德克萨斯阿尔茨海默病中心人口神经科学

• 批准号: 10270727
• 负责人: Claudia L Satizabal
• 金额: $ 12.87万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10270727
• 关键词: Address; Agreement; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Behavioral; Bioinformatics; Biological Markers; Biology; Blood; Brain imaging; Chemicals; Clinical; Cognitive; Collaborations; Communities; Consultations; Data; Dementia; Diabetes Mellitus; Disease; Doctor of Philosophy; Etiology; Face; Genome; Genomics; Goals; Health trends; Hispanic Americans; Hispanics; Image; Impaired cognition; Incidence; International; Knowledge; Life Cycle Stages; Life Style; Linguistics; Liquid substance; Magnetic Resonance Imaging; Methods; Mexican Americans; Monitor; Neurosciences; Neurosciences Research; Phenotype; Population; Population Research; Population Study; Positioning Attribute; Positron-Emission Tomography; Prevalence; Preventive measure; Process; Proteome; Protocols documentation; Public Health; Qualitative Research; Recommendation; Research; Research Methodology; Research Personnel; Resource Sharing; Resources; Risk Factors; Role; Services; Source; South Texas; Structure; Training; aging brain; cardiovascular risk factor; cognitive testing; cohort; cost effective; critical period; data harmonization; data integration; data management; data resource; data sharing; disorder risk; education research; epidemiology study; epigenome; ethnic minority population; health disparity; high risk; improved; innovation; insight; lipidome; metabolome; microbiome; modifiable risk; novel; population based; precision medicine; prevent; protective factors; psychosocial; racial minority; resilience; risk prediction; skills; statistics; tool; transcriptome; wearable device

ABSTRACT – Population Neuroscience Core The Population Neuroscience Core (PNC) of the South Texas Alzheimer’s Center (STAC) aims to advance our understanding of the life course factors contributing to Alzheimer’s Disease and Related Dementias, particularly in the understudied population of Mexican American Hispanic, who face an increased risk of the disease. To achieve this goal, our team will conduct cutting-edge epidemiological and neuroscience research to monitor the prevalence and incidence trends of health disparities in dementia, identify life-course risk and protective factors contributing to dementia, identify suitable and cost-effective biomarkers for risk prediction, and the develop culturally and linguistically appropriate tools for cognitive assessment in Mexican Americans from South Texas. The PNC has exceptional resources from existing longitudinal population-based cohorts, new studies focusing on Mexican Americans with deep phenotyping, and established national and international collaborations. The PNC aims to additionally close the gap of representation of Mexican Americans in epidemiological research. This will be achieved by the creation of a PNC sharing resource, where harmonized data to UDS and other standards in dementia research will be shared with other ADRCs and the scientific community. This setting allows the PNC to provide cognitively healthy controls for the Clinical and Neuropathological Cores as well as other ADRCs. Finally, we will train MDs, PhDs, and other professionals in population neuroscience, to develop skills in quantitative and qualitative research methods by leveraging local and national level data. The PNC will develop these aims in close collaboration with all STAC Cores. In summary, the PNC strategically positioned to be a national resource of valuable data from Mexican American Hispanics living in South Texas, and an asset to collaborative research centered on Alzheimer’s and related dementias research. We are fully integrated with the other STAC Cores to provide knowledge, data, services, tools, and training to investigators across the Center, as well as the broader ADRC and scientific community.

摘要：人口神经科学核心