Anti-inflammatory Activity of a Systemic STING Inhibitory Non-Nucleotide

系统性 STING 抑制性非核苷酸的抗炎活性

基本信息

  • 批准号:
    10382621
  • 负责人:
  • 金额:
    $ 30万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-12-17 至 2024-04-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Cellular innate immune sensors, such as STING (STIMULATOR OF INTERFERON GENES), have evolved to detect microbial infection of the cell. STING controls the potent cytosolic DNA-stimulated innate immune pathways and is activated by cyclic dinucleotides (CDNs) such as cyclic di-GMP and cyclic-di-AMP secreted by intracellular bacteria following infection. Alternatively, STING can be activated by cyclic GMP-AMP (cGAMP) generated by a cellular cGAMP synthase cGAS (MB21D1) after association with aberrant cytosolic dsDNA species, which can include microbial DNA or self-DNA leaked from the nucleus. Association with CDNs enables STING to activate the production of type I interferon (IFN) and pro-inflammatory cytokines, which facilitate adaptive immunity. The activation of STING is critical for protection against microbial infection and cancer. However, chronic STING activation is a leading cause of autoinflammatory disease such as severe systemic lupus erythematosus (SLE), STING associated vasculopathy with onset in infancy (SAVI) inflammation of the gut, tissue transplant rejection and others. Here, we describe a new generation of novel small STING antagonists that inhibit STING signaling, for evaluation as anti-inflammatory therapeutic agents. The compounds have been generated by STINGINN LLC, based in Miami, in collaboration with the University of Miami School of Medicine, FL.
项目总结

项目成果

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GLEN N BARBER其他文献

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{{ truncateString('GLEN N BARBER', 18)}}的其他基金

Human T cell Lymphotropic Virus Vaccine development
人类T细胞嗜淋巴细胞病毒疫苗的开发
  • 批准号:
    10554389
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:
Human T cell Lymphotropic Virus Vaccine development
人类T细胞嗜淋巴细胞病毒疫苗的开发
  • 批准号:
    10481417
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:

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