Anti-inflammatory Activity of a Systemic STING Inhibitory Non-Nucleotide
系统性 STING 抑制性非核苷酸的抗炎活性
基本信息
- 批准号:10382621
- 负责人:
- 金额:$ 30万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-12-17 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:Anti-Inflammatory AgentsAntibodiesBacteriaBarberingBindingBiological AssayCell NucleusCell divisionCellsChemicalsChronicClinical TrialsCollaborationsCyclic GMPCytosolCytotoxic T-LymphocytesDNADNA DamageDataDinucleoside PhosphatesDiseaseDisease modelEvaluationEventExhibitsFamilyFormulationGenerationsGenetic TranscriptionGraft RejectionHost DefenseHumanImmuneImmune systemImmunizationImmunologic ReceptorsInfectionInflammationInflammatoryInterferon Type IInterleukin-10LaboratoriesLeadListeria monocytogenesMalignant NeoplasmsMusMutationNucleic AcidsPathway interactionsPatientsPeriodicityPharmaceutical PreparationsPharmacodynamicsProductionProteinsRegulationReportingSTING agonistsSafetySignal TransductionStimulator of Interferon GenesSystemic Lupus ErythematosusT cell responseTherapeutic AgentsThree Prime Repair Exonuclease 1Tissue TransplantationToll-like receptorsUniversitiesVascular Diseasesadaptive immunityantagonistautoinflammatorybaseclinical developmentcytokinedesigndrug efficacyds-DNAefficacy evaluationgut inflammationhigh throughput screeningin vivoinfancyinhibitorinnate immune pathwaysinsightmedical schoolsmicrobialmouse modelnovelpathogenphase I trialpreventpseudotoxoplasmosis syndromeresponsescreeningsensorsmall molecule
项目摘要
PROJECT SUMMARY
Cellular innate immune sensors, such as STING (STIMULATOR OF INTERFERON GENES), have evolved to
detect microbial infection of the cell. STING controls the potent cytosolic DNA-stimulated innate immune
pathways and is activated by cyclic dinucleotides (CDNs) such as cyclic di-GMP and cyclic-di-AMP secreted by
intracellular bacteria following infection. Alternatively, STING can be activated by cyclic GMP-AMP (cGAMP)
generated by a cellular cGAMP synthase cGAS (MB21D1) after association with aberrant cytosolic dsDNA
species, which can include microbial DNA or self-DNA leaked from the nucleus. Association with CDNs enables
STING to activate the production of type I interferon (IFN) and pro-inflammatory cytokines, which facilitate
adaptive immunity. The activation of STING is critical for protection against microbial infection and cancer.
However, chronic STING activation is a leading cause of autoinflammatory disease such as severe systemic
lupus erythematosus (SLE), STING associated vasculopathy with onset in infancy (SAVI) inflammation of the
gut, tissue transplant rejection and others. Here, we describe a new generation of novel small STING antagonists
that inhibit STING signaling, for evaluation as anti-inflammatory therapeutic agents. The compounds have been
generated by STINGINN LLC, based in Miami, in collaboration with the University of Miami School of Medicine,
FL.
项目摘要
细胞先天免疫传感器,如STING(干扰素基因刺激物),已经进化为
检测细胞的微生物感染。STING控制有效的细胞溶质DNA刺激的先天免疫
通过环二核苷酸(CDN)激活,如由细胞分泌的环二GMP和环二AMP。
感染后的细胞内细菌。或者,STING可以通过环GMP-AMP(cGAMP)激活。
由细胞cGAMP合酶cGAS(MB 21 D1)在与异常胞质dsDNA结合后产生
物种,其中可以包括微生物DNA或从细胞核泄漏的自身DNA。与CDN的关联使
STING可激活I型干扰素(IFN)和促炎细胞因子的产生,
适应性免疫STING的激活对于防止微生物感染和癌症至关重要。
然而,慢性STING激活是自身炎性疾病如严重全身性炎症的主要原因。
红斑狼疮(SLE),STING相关血管病变与婴儿期发作(SAVI)炎症
肠道组织移植排斥反应等等在这里,我们描述了新一代新型小STING拮抗剂,
其抑制STING信号传导,用于评价作为抗炎治疗剂。这些化合物已经
由总部位于迈阿密的STINGINN LLC与迈阿密大学医学院合作产生,
花期
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GLEN N BARBER其他文献
GLEN N BARBER的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GLEN N BARBER', 18)}}的其他基金
Human T cell Lymphotropic Virus Vaccine development
人类T细胞嗜淋巴细胞病毒疫苗的开发
- 批准号:
10554389 - 财政年份:2022
- 资助金额:
$ 30万 - 项目类别:
Human T cell Lymphotropic Virus Vaccine development
人类T细胞嗜淋巴细胞病毒疫苗的开发
- 批准号:
10481417 - 财政年份:2022
- 资助金额:
$ 30万 - 项目类别:
相似海外基金
Developing protective monoclonal antibodies against Gram- and Gram+ bacteria
开发针对革兰氏菌和革兰氏菌的保护性单克隆抗体
- 批准号:
10162826 - 财政年份:2021
- 资助金额:
$ 30万 - 项目类别:
Developing protective monoclonal antibodies against Gram- and Gram+ bacteria
开发针对革兰氏菌和革兰氏菌的保护性单克隆抗体
- 批准号:
10577803 - 财政年份:2021
- 资助金额:
$ 30万 - 项目类别:
Developing protective monoclonal antibodies against Gram- and Gram+ bacteria
开发针对革兰氏菌和革兰氏菌的保护性单克隆抗体
- 批准号:
10352467 - 财政年份:2021
- 资助金额:
$ 30万 - 项目类别:
Strategies for generating high affinity antibodies against Gram negative bacteria
产生针对革兰氏阴性菌的高亲和力抗体的策略
- 批准号:
10117194 - 财政年份:2020
- 资助金额:
$ 30万 - 项目类别:
Investigating the effect of serum antibodies to periodontal bacteria on cardiorenal association
研究牙周细菌血清抗体对心肾关联的影响
- 批准号:
26861827 - 财政年份:2014
- 资助金额:
$ 30万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of rapid and simple diagnostic assays for 10 food poisoning bacteria and viruses using monoclonal antibodies
使用单克隆抗体开发针对 10 种食物中毒细菌和病毒的快速、简单的诊断方法
- 批准号:
26460807 - 财政年份:2014
- 资助金额:
$ 30万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The utility of serum IgG antibodies of periodontal pathogenic bacteria for obese patients treated for weight loss
牙周病原菌血清IgG抗体在肥胖患者减肥治疗中的应用
- 批准号:
25862052 - 财政年份:2013
- 资助金额:
$ 30万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Studies on rapid detection methods for multi-drug resistant bacteria by using specific antibodies
特异性抗体快速检测多重耐药菌方法的研究
- 批准号:
23659306 - 财政年份:2011
- 资助金额:
$ 30万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of rapid and simple diagnostic assays for food poisoning bacteria and viruses using monoclonal antibodies
使用单克隆抗体开发快速、简单的食物中毒细菌和病毒诊断方法
- 批准号:
23590749 - 财政年份:2011
- 资助金额:
$ 30万 - 项目类别:
Grant-in-Aid for Scientific Research (C)