CMA:Pulmonary and Systemic Effects of Deployment Related Particulate Matter Exposures
CMA:与部署相关的颗粒物暴露对肺部和全身的影响
基本信息
- 批准号:10383650
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Adaptive Immune SystemAirborne Particulate MatterAsiaAsthmaAutoantigensBiochemicalBioinformaticsBiological MarkersBiometryBiophysicsBostonCaliberCellsChronicClinicalCluster AnalysisComplementCoughingDataDesmosineDevelopmentDiffusionDiseaseDyspneaEosinophiliaExhalationExposure toFibrinogenFundingFutureGasesGoalsHealthHypersensitivityIgEImmuneImmune responseImmunityImmunologic MarkersImmunologyIndustrializationInflammasomeInflammatoryLungLung diseasesMeasurementMeasuresMilitary PersonnelNitric OxideParticipantParticulate MatterPatientsPhenotypePhysiologicalPulmonary Function Test/Forced Expiratory Volume 1Pulmonary InflammationPulmonary function testsQuantitative EvaluationsRecording of previous eventsReportingRespiratory Signs and SymptomsRiskSecretory CellServicesSiteSmokeSmoking HistorySoutheastern AsiaSphingolipidsSpirometryStructureStructure of parenchyma of lungSymptomsTechnologyTestingVeteransWheezingX-Ray Computed Tomographyairway inflammationairway obstructionbasebiomarker discoveryburn pitclinical applicationcohortcooperative studycytokinedesigndisorder subtypedust stormseosinophilic inflammationfine particlesformer smokerimaging biomarkerimmune activationinjured airwaylung injurymetabolomicsmonocytemultiple omicsnon-smokerparent projectpollutantpulmonary functionrecruitrespiratoryresponsesecretory proteinsoluble RAGEsoundsystemic inflammatory responsetreatment strategy
项目摘要
Military personnel deployed to Southeast Asia (SA) report increased respiratory symptoms. Unique to
SA deployment is a history of exposure to high levels of airborne particulate matter ≤ 2.5 µm in diameter
(PM2.5) consisting of seasonal dust storms, burn-pit smoke, and unregulated industrial and vehicular pollutants.
Objective findings among returning Veterans are limited, therefore, the VA Cooperative Study #595 Service
and Health Among Deployed Veterans (SHADE) was funded to assess satellite confirmed exposure history
during land-based deployments to SA, in nearly 5000 at risk Veterans in six centers. The overall aim of
SHADE (Parent Project) is to associate PM2.5 exposure with spirometrically assessed pulmonary function, and
asthma history. Because SHADE offers a unique opportunity to identify early deployment-related lung findings
related to PM exposure, we propose to use this cohort to identify biophysical and clinical impact of PM
exposure through three inter-related Aims. To accomplish our goals we will recruit 280 SHADE participants
with (50%) and without (50%) respiratory symptoms (chronic cough, wheeze, or dyspnea) who are non- or
former-smokers with <10 pack year history of smoking from four participating SHADE sites (Minneapolis,
Houston, Boston and Seattle). This study will provide evidence for the systemic effects of exposure with
linkage to respiratory symptoms and reduced pulmonary function.
This proposal is one of three coordinated projects to systematically examine pulmonary and systemic
effects of exposure during deployment. Specifically, this project will use state-of-the-art technology and
expertise (biomarker discovery, multi-omic analysis, immunology and bioinformatics) to provide a
comprehensive assessment of systemic inflammatory and airway related biomarkers in deployment-related
PM2.5 exposure. Further, our proposed approach using systemic and immune based biomarkers contributes to
the overall rationale for our Collaborative Merit Applications. We will test the hypothesis that increased
systemic biomarkers of airway and pulmonary injury and/or immune cell activation status will
distinguish previously deployed veterans with and without respiratory symptoms and associate with
greater deployment related PM2.5 exposures. Specifically, we will examine the association between systemic
biomarkers of airway injury with activation of the innate and acquired immune system to respiratory symptoms,
lung function parameters, and PM2.5 exposures.
In this collaborative proposal all four sites will study the same 280 patients that in addition to biomarker
studies will have lung structure evaluation by quantitative CT imaging (Boston VA project) and additional
physiologic characterization using diffusion capacity and exhaled nitric oxide to evaluate eosinophilic airway
inflammation (Seattle VA project). Using well-designed biostatistical approaches, we will test our hypothesis
that greater exposure to PM2.5 results in specific airway and lung parenchymal endotypes that could be
distinguished by functional, structural, and biochemical mechanisms. Our three coordinated proposals will
complement CSP #595 by comprehensively characterizing early deployment-related lung findings related to
PM2.5 exposure that may in the future be used to assess disease. The resultant exposure-related disease types
identified provide new clinical applications for the recognition, management, and future treatment strategies for
Veterans with deployment-related lung disease.
部署到东南亚的军事人员报告呼吸道症状加重。独有的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Farrah Kheradmand其他文献
Farrah Kheradmand的其他文献
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{{ truncateString('Farrah Kheradmand', 18)}}的其他基金
CMA:Pulmonary and Systemic Effects of Deployment Related Particulate Matter Exposures
CMA:与部署相关的颗粒物暴露对肺部和全身的影响
- 批准号:
9774557 - 财政年份:2020
- 资助金额:
-- - 项目类别:
CMA:Pulmonary and Systemic Effects of Deployment Related Particulate Matter Exposures
CMA:与部署相关的颗粒物暴露对肺部和全身的影响
- 批准号:
10553621 - 财政年份:2020
- 资助金额:
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Toxic Effects of Ecigs Following Transition From Conventional Cigarettes
从传统香烟过渡到电子烟后的毒性作用
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9982334 - 财政年份:2018
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Admin Suppl to examine the role of Vit E Acetate in ENDS
行政补充检查维生素 E 醋酸酯在 ENDS 中的作用
- 批准号:
10060130 - 财政年份:2018
- 资助金额:
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Ancillary T Cell Based Studies in SPIROMICS
基于 SPIROMICS 的辅助 T 细胞研究
- 批准号:
8266804 - 财政年份:2012
- 资助金额:
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Ancillary T Cell Based Studies in SPIROMICS
基于 SPIROMICS 的辅助 T 细胞研究
- 批准号:
8794458 - 财政年份:2012
- 资助金额:
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Ancillary T Cell Based Studies in SPIROMICS
基于 SPIROMICS 的辅助 T 细胞研究
- 批准号:
8604407 - 财政年份:2012
- 资助金额:
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Ancillary T Cell Based Studies in SPIROMICS
基于 SPIROMICS 的辅助 T 细胞研究
- 批准号:
8424239 - 财政年份:2012
- 资助金额:
-- - 项目类别:
VIRAL-INDUCED T CELL RESPONSES IN COPD EXACERBATION PROTOCOL: LES COPD
COPD 恶化方案中病毒诱导的 T 细胞反应:LES COPD
- 批准号:
8356768 - 财政年份:2010
- 资助金额:
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Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
人类慢性阻塞性肺病和肺气肿的先天性和适应性免疫的调节
- 批准号:
8195974 - 财政年份:2009
- 资助金额:
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