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Meaningful Activity Intervention for Individuals With Early-Stage Dementia: Involving the End User in Intervention Design

对早期痴呆症患者进行有意义的活动干预：让最终用户参与干预设计

基本信息

批准号：
10381709
负责人：
Natalie Grace Regier
金额：
$ 15.53万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10381709
关键词：
Address Affect Aggressive behavior Agitation Alzheimer&apos s Disease Awareness Biological Markers Boredom Caregivers Characteristics Clinic Clinical Investigator Cognition Communities Degenerative Disorder Dementia Development Disease Disease Progression Distress Elderly Emotions Exclusion Failure Feedback Focus Groups Frequencies Home Individual Intervention Intervention Studies Lead Link Literature Location Loneliness Long-Term Care Measures Medical center Memory Mentored Patient-Oriented Research Career Development Award Neurologic Outcome Participant Personal Satisfaction Persons Pilot Projects Plant Roots Play Population Prevalence Protocols documentation Public Health Randomized Controlled Trials Research Research Personnel Role Sensory Deprivation Series Services Severities Targeted Research Testing Therapeutic Intervention Training Universities Work adverse outcome base career catalyst dementia care depressive symptoms design expectation implementation intervention improved informant interest knowledge base neuropsychiatric symptom novel open label pilot test preservation prototype randomized trial recruit social symptom management symptomatology therapeutically effective therapy design therapy development treatment planning

项目摘要

Abstract The aim of this NIA Mentored Patient-Oriented Research Career Development Award application is to support my career objective to become an independent clinical investigator specializing in the design and implementation of non-pharmacological interventions for persons with dementia. Throughout the literature, the majority of intervention studies have targeted persons with at least moderate dementia and have not involved the person with dementia in the construction of the intervention(s). In preliminary studies on which I served as a co-investigator, tailored interventions demonstrated beneficial impact on neuropsychiatric symptoms of dementia but did not significantly impact measures of well- being (i.e., depressive symptomatology). Thus, it is important to examine whether intervention implementation at an earlier stage of dementia and greater involvement of persons with dementia in the intervention design lead to better immediate and long-term outcomes. I propose a training plan that will facilitate the development of a protocol for the collaborative creation of a tailored activity plan. This training plan will also allow me to gain the necessary knowledge base to conduct a larger, randomized controlled trial that incorporates neurological biomarkers of dementia. The proposed five-year research plan represents a novel and critical contribution to the field by developing the first service user- led meaningful activity intervention for persons with early-stage dementia. The specific aims of the proposed research are to: (1) identify delivery characteristics of an activity intervention for persons with dementia at the early stage, (2) evaluate the feasibility, acceptability, and initial potential benefits of this protocol, and (3) evaluate the feasibility of the revised protocol and examine its effects on outcomes. An exploratory aim is to evaluate whether the activities are used independently of the intervention (i.e., sustainable). A total of 60 community-dwelling older adults with early dementia (≥60 years) will be recruited to participate in the pilot study. These participants will be drawn from the Johns Hopkins University Maximizing Independence (MIND) at Home study, the Johns Hopkins Bayview Medical Center Memory Clinic, and community-based social agencies such as the Alzheimer’s Association. The expectation is that the findings from this project will ultimately advance the field of dementia care through analysis of the long-term benefits of implementing activities early-on and the benefits to persons with dementia of participating in intervention design.

摘要这个NIA指导的以患者为导向的研究职业发展奖的目的申请是为了支持我的职业目标，成为一名独立的临床研究者专门设计和实施非药物干预，痴呆症患者。纵观文献，大多数干预研究目标人群至少患有中度痴呆症，并且没有涉及患有在干预措施的建设中的痴呆症。在我参与的初步研究中，作为共同研究者，量身定制的干预措施对神经精神症状的痴呆，但没有显着影响措施的良好，是（即，抑郁症）。因此，重要的是要检查是否在老年痴呆症的早期阶段实施干预措施，痴呆症患者在干预设计导致更好的即时和长期结果。我提出了一项培训计划，将有助于制定一项议定书，协作创建定制的活动计划。这个训练计划也会让我进行更大规模的随机对照试验所需的知识基础，结合了痴呆症的神经生物标志物。五年研究计划通过开发第一个服务用户- 对早期痴呆症患者进行有意义的活动干预。具体目标建议的研究是：（1）确定一个活动的交付特性对痴呆症患者进行早期干预，（2）评估可行性，可接受性和本方案的初始潜在受益，以及（3）评价修订后的议定书，并审查其对结果的影响。一个探索性的目标是评估活动是否独立于干预使用（即，可持续）。了60余将招募患有早期痴呆症（≥60岁）的社区居住老年人，参与试点研究。这些参与者将来自约翰霍普金斯大学约翰霍普金斯湾景大学最大化独立性（MIND）研究医疗中心记忆诊所，以及社区为基础的社会机构，如老年痴呆症协会。我们期望这个项目的结果最终能通过分析老年痴呆症的长期益处，开展早期活动，以及痴呆症患者参加干预设计

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

COVID-19: Implications for Nursing and Health Care in the United States.

DOI：
10.1111/jnu.12853
发表时间：
2023-01
期刊：
JOURNAL OF NURSING SCHOLARSHIP
影响因子：
3.4
作者：
Reynolds, Nancy R.;Baker, Deborah;D'Aoust, Rita;Docal, Maria;Goldstein, Nancy;Grubb, Lisa;Hladek, Melissa D.;Koirala, Binu;Kverno, Karan;Ling, Catherine;Lukkahatai, Nada;McIltrot, Kimberly;Pandian, Vinciya;Regier, Natalie G.;Sloand, Elizabeth;Tomori, Cecilia;Wenzel, Jennifer
通讯作者：
Wenzel, Jennifer

Perceived Decisional Control as a Mediator between Moving to Assisted Living Due to Caregiver Burden and Relocation Adjustment.

将决策控制视为因看护者负担而转向辅助生活与搬迁调整之间的中介。