Examination of Myopia Progression and Consequences and Mechanism of Soft Multifocal Contact Lens Myopia Control

近视进展及后果及软性多焦点隐形眼镜近视控制机制的研究

• 批准号: 10382378
• 负责人: JEFFREY JAY WALLINE
• 金额: $ 11.71万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382378
• 关键词: 11 year old; Address; Affect; Applications Grants; Biological Markers; Biometry; Blindness; Caring; Child; Childhood; Clinical; Contact Lenses; Data; Enrollment; Environment; Environmental Risk Factor; Exposure to; Eye; Goals; Growth; Health Care Costs; Light; Measurement; Measures; Mediating; Monitor; Myopia; National Eye Institute; Optics; Outcome; Outcome Study; Participant; Patients; Peripheral; Persons; Photosensitivity; Pupil; Quality of life; Randomized; Randomized Clinical Trials; Refractive Errors; Retinal Ganglion Cells; Risk; Safety; Secondary to; Shapes; Study Subject; Testing; Thick; Time; United States; Vision; Visit; burden of illness; clinical practice; design; efficacy evaluation; experience; follow-up; improved; lens; longitudinal dataset; negative affect; patient subsets; response; risk minimization; side effect; standard of care; treatment effect; treatment group

The primary goal of the BLINK2 Study is to determine correlates of myopia progression using non-invasive measurement of biomarkers (choroidal thickness and intrinsically photosensitive retinal ganglion cell-mediated pupil function) and outdoor light exposure in children. If multifocal contact lenses slow the progression of myopia by 30% or more compared to single vision contact lenses during the BLINK Study, we will also answer important questions about the consequences and mechanism of the treatment effect, such as whether multifocal contact lens wear alters accommodative function and whether or not the treatment benefit is transient. Specifically, we will investigate whether myopia progression is slowed or simply delayed by multifocal contact lens wear and whether there is a “rebound” in myopia progression, an increase in progression rate, after discontinuation of multifocal contact lenses. We will identify myopic children who will most benefit from myopia control by determining those who are most likely to progress, thereby maximizing the potential for benefit and minimizing risk. We will accomplish this goal by investigating the effect on progression of the most important ocular and environmental risk factors recently hypothesized to control eye growth. The project will collect the most extensive longitudinal dataset ever on choroidal thickness in childhood myopia. We will test the important question of whether time outdoors and light exposure influence myopia progression after onset in addition to whether these affects are mediated by intrinsically photosensitive retinal ganglion cells. If soft multifocal contact lenses show a clinically meaningful slowing of myopia progression, we will also answer important questions asked routinely by our clinical colleagues. We will know the accommodative effect of multiple years of multifocal contact lens wear in children, we will know if multifocal contact lenses slow or simply delay myopia progression, and we will know whether myopia progression increases following discontinuation of soft multifocal contact lens wear. Answers to questions addressed by this proposal could improve care for 60 million myopic children in the United States. While the consequences of ordinary myopia are rarely sight-threatening, the quality of life for myopic patients is negatively affected and the health care costs to treat myopia are high (approximately $4.6 billion in 1990). The National Eye Institute recognizes the need to "evaluate the efficacy of potential treatments for delaying the onset or for slowing the progression of myopia, such as lenses that alter peripheral defocus." The BLINK2 Study seeks to maximize benefit while lowering the risk of multifocal contact lens wear for myopia control while answering important scientific and clinical questions about the consequences and mechanism of myopia progression, a problem that affects many people in the United States.

BLINK2研究的主要目标是使用非侵入性测量来确定近视进展的相关性。 生物标志物（脉络膜厚度和固有光敏视网膜神经节细胞介导的视网膜神经节细胞）的测量 瞳孔功能）和儿童户外光照。如果多焦点隐形眼镜减缓了 在BLINK研究中，与单视角膜接触镜相比，近视减少30%或更多，我们还将回答 关于治疗效果的后果和机制的重要问题，例如 多焦点接触透镜配戴改变了屈光功能， 短暂的具体来说，我们将调查是否近视进展减缓或只是延迟多焦点 接触透镜佩戴和近视进展中是否存在“反弹”，进展速率的增加， 停用多焦点隐形眼镜后。 我们将确定哪些近视儿童将最受益于近视控制， 最有可能取得进展，从而最大限度地提高受益潜力，最大限度地降低风险。要全面完成 通过研究最重要的眼部和环境风险因素对进展的影响来实现这一目标 最近被假设可以控制眼睛的生长。该项目将收集最广泛的纵向数据集 对儿童近视眼脉络膜厚度的影响。我们将测试一个重要的问题， 和光暴露影响近视发病后的进展，除了这些影响是否介导 由视网膜神经节细胞产生的。如果软性多焦点角膜接触镜显示出临床上有意义的 减缓近视进展，我们还将回答我们的临床医生经常提出的重要问题。 同事我们将知道多年配戴多焦点接触透镜的效果， 孩子们，我们将知道多焦点隐形眼镜是否会减缓或只是延缓近视的进展， 停止佩戴软性多焦点接触透镜后近视进展是否会增加。 该提案所解决的问题的答案可以改善6000万近视儿童的护理， 美国的虽然普通近视的后果很少危及视力，但 近视患者受到负面影响并且治疗近视的健康护理费用很高（大约4.6美元 1990年）。国家眼科研究所认识到有必要“评估潜在治疗方法的疗效 用于延迟近视的发作或减缓近视的发展，例如改变周边散焦的透镜。" BLINK2研究旨在最大化获益，同时降低因近视配戴多焦接触透镜的风险 控制，同时回答重要的科学和临床问题的后果和机制， 近视进展，一个影响美国许多人的问题。