Histamine in homes: Exposure risks and health effects

家庭中的组胺：暴露风险和健康影响

• 批准号: 10472670
• 负责人: Zachary DeVries
• 金额: $ 35.58万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472670
• 关键词: Address; Adjuvant; Affect; Alcoholic Beverages; Allergens; Allergic Disease; Archives; Arthropods; Asthma; Atopic Dermatitis; Award; Bacteria; Bedbugs; Beds; Behavior; Biological; Biology; Biotechnology; Blood; Bypass; Canis familiaris; Cell Culture Techniques; Characteristics; Chemicals; Chronic; Communities; Defecation; Deposition; Dermal; Development; Disadvantaged; Dust; Educational process of instructing; Eligibility Determination; Entomology; Environmental Health; Environmental Pollution; Environmental Risk Factor; Epidemiology; Exposure to; Extrinsic asthma; Faculty; Fecal analysis procedure; Feces; Fishes; Food; Funding; Health; Health Care Costs; Histamine; Histamine Production; Home; House Dust; Human; Hygiene; Hypersensitivity; Hypersensitivity skin testing; Immune response; Indoor environment; Inflammation; Infrastructure; Ingestion; Institution; International; Leadership; Life; Location; Low income; Mass Fragmentography; Mentors; Mentorship; Microbe; Mus; National Institute of Environmental Health Sciences; Outcome; Personal Satisfaction; Persons; Phase; Postdoctoral Fellow; Prevalence; Productivity; Pruritus; Public Health; Publications; Quality of life; Reaction; Research; Research Personnel; Research Support; Risk; Risk Factors; Sampling; Science; Scientist; Skin; Source; Spatial Distribution; Testing; Training; United States; United States National Institutes of Health; Universities; Vasodilation; Wages; air sampling; allergic response; asthmatic; career; clinical effect; clinically relevant; cohort; cost; dermal exposure; environmental toxicology; experience; exposed human population; feeding; gut microbiome; inner city; innovation; interdisciplinary approach; multidisciplinary; neuroregulation; post-doctoral training; programs; residence; respiratory; rho; stem; undergraduate student

Exposure to indoor environmental contaminants is a major health risk factor, particularly in relation to allergic disease and asthma. In the United States alone, over 50 million people suffer from allergies each year, with an estimated annual cost of over $18 billion. Although numerous contaminants have been identified indoors, mitigation in most cases is possible because their sources, chemical characteristics, dissemination, and health effects have been identified. Contaminants that tend to be particularly challenging to manage are those that either remain un-identified or that we do not fully understand. Bed bugs have resurged globally during the last 20 years, severely affecting the quality of life in disadvantaged communities. I recently discovered and quantified large amounts of histamine in bed bug-infested homes. Although histamine has been extensively investigated as a food contaminant in fish and alcoholic beverages, chronic exposure to histamine has not been considered because histamine has never been detected as a contaminant in homes. Histamine is a downstream modulator in the mammalian immune response, and it is routinely used in provocation tests, including bronchial challenge and skin tests. The presence of large histamine deposits in household dust and its multiple clinical effects (e.g., vasodilation, inflammation, neuromodulation) predict that dermal and respiratory exposure to histamine could constitute a serious health risk. I therefore hypothesize that histamine is ubiquitous in bed bug infested homes, particularly in inner-city low-income residences, and chronic exposure to histamine poses serious health risks to humans. I propose an integrated and interdisciplinary approach to understand the contribution of bed bugs to histamine residues in homes, the pervasiveness and spatial distribution of histamine in the indoor environment, and the effects of histamine on human health. If successful, this project will identify a new environmental contaminant that has gone undetected and unabated for almost two decades. To this end, I will address the following specific aims: 1. Quantify bed bug histamine production and determine the extent of histamine production in other arthropods. 2. Characterize the spatial distribution of histamine in bed bug infested homes. 3. Correlate environmental histamine with the bed bug resurgence and adverse health outcomes 4. Determine the bioactivity and clinical relevance of bed bug derived histamine Presently, no programs offer the opportunity to conduct cutting edge research at the intersection of indoor entomology and public health. Therefore, to address the problems outlined above, I require research independence. This award, supported by significant commitments from my host institution, will provide me with the infrastructure and mentoring to rapidly develop into an independent researcher. I am well-prepared to bypass the traditional post-doctoral phase because of my experience working on projects that span several levels of biological organization, my leadership in international collaborative projects, mentorship of several undergraduate students, strong publication record, and my proven ability to coordinate large-scale multi-disciplinary studies. The experience I have gained and my productivity during my graduate training surpasses what many scientists achieve during the first 3–5 years of post-doctoral training.

接触室内环境污染物是主要的健康危险因素，尤其是在过敏性疾病和 哮喘。仅在美国，每年有超过5000万人患有过敏症，估计每年成本 超过180亿美元。尽管已经在室内发现了许多污染物，但在大多数情况下可以缓解 因为已经确定了它们的来源，化学特征，传播和健康效应。污染物 管理往往特别具有挑战性的是那些尚未确定或我们不完全理解的人。 在过去的20年中，臭虫在全球恢复了，严重影响了灾难中生活质量 社区。我最近发现并量化了臭虫感染房屋中的大量组胺。虽然 组胺已被广泛研究为鱼类和酒精卧室中的食物污染物，长期暴露于 没有考虑组胺，因为从未发现组胺在家庭中被发现为污染物。组胺是 哺乳动物免疫反应中的下游调节剂，它通常用于挑衅测试，包括 支气管挑战和皮肤测试。家庭灰尘及其多个临床中存在大型组胺沉积 影响（例如，血管舒张，炎症，神经调节）预测，皮肤和呼吸道暴露于组胺 可能构成严重的健康风险。因此，我假设组胺在臭虫感染的房屋中无处不在， 特别是在市中心的低收入住宅中，长期暴露于组胺会对人类带来严重的健康风险。 我提出了一种综合和跨学科的方法，以了解臭虫对组胺残基的贡献 在房屋中，组胺在室内环境中的普遍性和空间分布以及组胺的作用 关于人类健康。如果成功，该项目将确定未被发现的新环境污染物，并且 近二十年来没有减弱。为此，我将解决以下具体目标： 1。量化臭虫组胺的产生，并确定其他节肢动物中组胺产生的程度。 2。表征臭虫感染房屋中组胺的空间分布。 3。将环境组胺与臭虫恢复和不良健康结果相关联 4。确定臭虫得出的组胺的生物活性和临床相关性 目前，没有计划在室内昆虫学的交汇处进行尖端研究的机会 和公共卫生。因此，要解决上述问题，我需要研究独立性。这个奖项， 在我的房东机构的重大承诺的支持下，将为我提供基础设施和心理 迅速发展成为独立的研究人员。我已经准备好绕过传统的博士后阶段，因为 我从事跨越几个生物组织的项目的经验，我在国际上的领导 协作项目，几位本科生的指导力量，强大的出版记录以及我的久经考验的能力 协调大型多学科研究。我在毕业生中获得的经验和生产力 培训表面许多科学家在博士后培训的前3 - 5年中取得的成就。