Training Core

培训核心

• 批准号: 10473538
• 负责人: Beverly A Rothermel
• 金额: $ 15.96万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10473538
• 关键词: Accreditation; Address; Back; Basic Science; Biomedical Research; Blood; CRISPR/Cas technology; Career Mobility; Clinical Sciences; Communities; Complement; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Duchenne muscular dystrophy; Elements; Environment; Fellowship; Funding; Generations; Genome; Goals; Learning; Mediating; Medical center; Medicine; Mentors; Mission; Muscle; Muscular Dystrophies; Patients; Physicians; Process; Research; Research Personnel; Sampling; Scientist; Services; Technology; Texas; Training; Training Activity; Training Programs; Translations; Universities; Work; base; career; design; educational atmosphere; genome editing; induced pluripotent stem cell; meetings; neuromuscular; next generation; programs; recruit

Project Summary/Abstract The techniques of CRISPR/Cas9-mediated genomic editing and the ability to generate induced pluripotent stem cells (iPSCs) from a sample of a patient’s blood have placed medicine on the brink of a revolution in our ability to treat, and perhaps even cure, a broad range of genome-based diseases. Over the past four years the Wellstone Muscular Dystrophy Cooperative Research Center at the University of Texas Southwestern Medical Center (now the UTSW Wellstone MDSRC) has made tremendous strides toward the translation of this technology to benefit patients with Duchenne muscular dystrophy, and ultimately, other forms of muscular dystrophy. The mission of the Training Core has been just as impactful as it is essential to train a new generation of clinicians, physician-scientists, and basic scientists who are able to apply these evolving technologies in the service of muscular dystrophy patients and their community. The objective of the training core is to enhance the educational environment of the Wellstone network in order to recruit, train, and maintain the next generation of transformative investigators focused on addressing the challenges of muscular dystrophy. Our approach focuses on five elements: (Aim 1) To enhance the training environment of the UTSW Wellstone Center and promote trainee career advancement, (Aim 2) To recruit new trainees to muscular dystrophy research, (Aim 3) To mentor trainees in the process of obtaining funding support for the next step in their careers, (Aim 4) To organize research meetings involving Wellstone trainees, and (Aim 5) To organize training activities that benefit the overall muscular dystrophy research community. To accomplish these goals, we’ve built on the very successful program developed over the past four years of funding, that has both complemented and leveraged the strengths of existing training programs here at UTSW.

项目概要/摘要 CRISPR/Cas9介导的基因组编辑技术和产生诱导基因的能力 来自患者血液样本的多能干细胞（iPSC）使药物处于濒临崩溃的边缘。 我们治疗甚至治愈多种基于基因组的疾病的能力发生了革命。超过 过去四年，韦尔斯通肌营养不良症合作研究中心在大学 德克萨斯西南医学中心（现为 UTSW Wellstone MDSRC）取得了巨大进步 致力于将该技术转化为造福杜氏肌营养不良症患者，以及 最终，其他形式的肌营养不良症。培训核心的使命正如 具有影响力，因为它对于培训新一代临床医生、医师科学家和基础科学家至关重要 他们能够应用这些不断发展的技术为肌营养不良症患者及其患者提供服务 社区。培训核心的目标是改善 Wellstone 的教育环境 网络，以招募、培训和维持下一代变革性调查人员的重点 应对肌营养不良症的挑战。我们的方法侧重于五个要素：（目标 1） 改善UTSW Wellstone中心的培训环境并促进学员职业发展 进步，（目标 2）招募新学员进行肌肉营养不良研究，（目标 3）指导 学员在为其职业生涯的下一步获得资金支持的过程中，（目标 4）组织 涉及 Wellstone 受训人员的研究会议，以及（目标 5）组织有益于他们的培训活动 整个肌营养不良症研究界。为了实现这些目标，我们建立在 在过去四年的资助中制定了成功的计划，既补充又补充了 利用 UTSW 现有培训计划的优势。