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Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli

Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli
促炎刺激调节金属转运蛋白 ZIP14 的功能
批准号：
10474233
负责人：
ROBERT J COUSINS
金额：
$15.24万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-09-23 至 2023-08-31
来源：
https://reporter.nih.gov/project-details/10474233
关键词：
AblationAcute-Phase ProteinsAddressBindingBinding SitesBiological AssayCCAAT-Enhancer-Binding ProteinsCatalytic DomainChelating AgentsComputer softwareDNA MethylationDataDeacetylationDietDietary ZincEffectivenessEnterocytesEnzymesEpigenetic ProcessEpithelial CellsEventFemaleGATA4 geneGene ExpressionGenesGenetic TranscriptionGenomic DNAGenotypeGoalsHDAC1 geneHDAC3 geneHealthHealth PromotionHistone AcetylationHistone DeacetylaseHistone Deacetylase InhibitorHistonesHumanIL18 geneImmunityIndividualInflammationIntestinal permeabilityIntestinesLeaky GutLinkLiteratureMeasuresMediatingMetalsMethylationMicroRNAsMicronutrientsModificationMusNF-kappa BNuclear ExtractNuclear ProteinsNuclear ReceptorsPermeabilityPharmaceutical PreparationsProductionProteinsReagentReportingResearchReverse Transcriptase Polymerase Chain ReactionSTAT3 geneSignal PathwaySiteSkeletal MuscleSmall IntestinesStimulusStructureSuggestionTestingTimeTrichostatin AZincZinc FingersZinc supplementationbasechelationchromatin immunoprecipitationchromatin modificationclaudin-1 proteindemethylationdietarydifferential expressiondrinking waterexperimental studygenome browserhistone acetyltransferasehistone demethylasehistone methylationhistone modificationin silicoindexinginhibitor/antagonistinterestintestinal barrierintestinal epitheliumintestinal homeostasismicrobialpreventpromoterprotein expressionresponsesystemic inflammatory responsetranscription factor

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中文摘要
翻译
摘要：针对R56项目
英文摘要
Abstract For This R56 Project Guiding Hypothesis: Zinc transport mediated by Zip14 (Slc39a14) influences gene expression in enterocytes that in turn alters intestinal barrier function. Goal: Evaluate mechanisms of enterocyte-specific Zip14 ablation and replacement zinc supplementation on epigenetic alterations including histone methylation and acetylation, transcription factor activation and lncRNAs and miRNAs that regulate genes in intestinal epithelial cells which influence barrier function.
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15th International Symposium on Trace Elements in Man and Animals (TEMA15)
  • 批准号：
    8720288
  • 项目类别：
  • 资助金额：
    $1.8万
  • 财政年份：
    2014
  • 负责人：
    ROBERT J COUSINS
  • 依托单位：
    UNIVERSITY OF FLORIDA
Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
  • 批准号：
    8335469
  • 项目类别：
  • 资助金额：
    $28.68万
  • 财政年份：
    2011
  • 负责人：
    ROBERT J COUSINS
  • 依托单位：
    UNIVERSITY OF FLORIDA
Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
  • 批准号：
    8535747
  • 项目类别：
  • 资助金额：
    $27.67万
  • 财政年份：
    2011
  • 负责人：
    ROBERT J COUSINS
  • 依托单位：
    UNIVERSITY OF FLORIDA
Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
  • 批准号：
    8721947
  • 项目类别：
  • 资助金额：
    $28.68万
  • 财政年份：
    2011
  • 负责人：
    ROBERT J COUSINS
  • 依托单位：
    UNIVERSITY OF FLORIDA
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