Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli

促炎刺激调节金属转运蛋白 ZIP14 的功能

• 批准号: 10474233
• 负责人: ROBERT J COUSINS
• 金额: $ 15.24万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474233
• 关键词: Ablation; Acute-Phase Proteins; Address; Binding; Binding Sites; Biological Assay; CCAAT-Enhancer-Binding Proteins; Catalytic Domain; Chelating Agents; Computer software; DNA Methylation; Data; Deacetylation; Diet; Dietary Zinc; Effectiveness; Enterocytes; Enzymes; Epigenetic Process; Epithelial Cells; Event; Female; GATA4 gene; Gene Expression; Genes; Genetic Transcription; Genomic DNA; Genotype; Goals; HDAC1 gene; HDAC3 gene; Health; Health Promotion; Histone Acetylation; Histone Deacetylase; Histone Deacetylase Inhibitor; Histones; Human; IL18 gene; Immunity; Individual; Inflammation; Intestinal permeability; Intestines; Leaky Gut; Link; Literature; Measures; Mediating; Metals; Methylation; MicroRNAs; Micronutrients; Modification; Mus; NF-kappa B; Nuclear Extract; Nuclear Proteins; Nuclear Receptors; Permeability; Pharmaceutical Preparations; Production; Proteins; Reagent; Reporting; Research; Reverse Transcriptase Polymerase Chain Reaction; STAT3 gene; Signal Pathway; Site; Skeletal Muscle; Small Intestines; Stimulus; Structure; Suggestion; Testing; Time; Trichostatin A; Zinc; Zinc Fingers; Zinc supplementation; base; chelation; chromatin immunoprecipitation; chromatin modification; claudin-1 protein; demethylation; dietary; differential expression; drinking water; experimental study; genome browser; histone acetyltransferase; histone demethylase; histone methylation; histone modification; in silico; indexing; inhibitor/antagonist; interest; intestinal barrier; intestinal epithelium; intestinal homeostasis; microbial; prevent; promoter; protein expression; response; systemic inflammatory response; transcription factor

Abstract For This R56 Project Guiding Hypothesis: Zinc transport mediated by Zip14 (Slc39a14) influences gene expression in enterocytes that in turn alters intestinal barrier function. Goal: Evaluate mechanisms of enterocyte-specific Zip14 ablation and replacement zinc supplementation on epigenetic alterations including histone methylation and acetylation, transcription factor activation and lncRNAs and miRNAs that regulate genes in intestinal epithelial cells which influence barrier function.

摘要：针对R56项目