Cardiovascular Outcomes Research in Perioperative Medicine - COR-PM

摘要 麻醉学研究为患者安全和护理质量的显著改善做出了贡献。 尽管在美国，每百万外科出院人数中只有8.2人死亡是次要的 明显的麻醉并发症，住院手术后的30天死亡率仍然在1.3%的范围内。的 非心脏手术后30天死亡率的最常见和潜在可预防的原因是 心血管事件。全世界有超过3亿患者接受手术， 减少人类痛苦和伤害的围手术期护理的改进是巨大的。尽管 与围手术期死亡率的相关性，高质量的临床心血管结局研究， 特别是，在美国大多数学术麻醉部门中不常见。 事实上，医生和科学家劳动力的持续下降促使NIH主任弗朗西斯博士 柯林斯，召集医生科学家工作组，提供建议，以加强其 鲁棒性和多样性。麻醉学领域落后于NIH的资金，例如，相比 外科或内科。然而，尽管努力为初级申请人提供有竞争力的 优势，从职业发展到独立调查员地位的关键过渡，往往 被称为"K2R"，仍然是一个重大挑战，特别是对妇女和调查人员， 医学背景的人数不足。目前，导师/学员的典型模式是 关系取决于身体上的接近程度。COR-PM挑战这一现状，提出 来自美国各地的学员领导跨机构的指导工作，这将是独立的， 学员和导师的实际位置。为了实现会议的目标，研究人员 设计了一个由来自美国各地的25名初级调查人员组成的指导小组， 一个由独立调查人员组成的国际八人高级顾问小组， 临床心血管结局研究的成功记录。使用"学员-带 导师-对于学员的范例，研究者提出了三个具体目标。目标1：组织 2022围手术期医学心血管结局研究-COR-PM以推进临床 T2-T4转化谱内心血管医学的结果研究。目标2：提供 初级调查员的辅导能力，通过以下方式向与会者提供切实的辅导： 将学员与各机构的导师配对。目标3：创建一个包容和欢迎的会议 在会议规划和执行的所有方面，通过加强多样性，营造良好的气氛。的 本次会议的预期成果是让与会者获得围手术期领域的知识， 心血管结局研究，并受益于建立指导关系以外的 各自的家庭机构。因此，COR-PM将产生直接和积极的影响。

Abstract Anesthesiology research has contributed to dramatic improvements in patient safety and quality of care. Although in the United States, only 8.2 deaths per million surgical hospital discharges are secondary to apparent anesthetic complications, 30-day mortality after inpatient surgeries still ranges at 1.3%. The most common and potentially preventable causes of 30-day mortality after non-cardiac surgery are cardiovascular events. With more than 300 million patients having surgeries worldwide, the potential of improvements in perioperative care to reduce human suffering and harm is immense. Despite its relevance to perioperative mortality, high-quality clinical cardiovascular outcomes research, in particular, is not commonly conducted in the majority of US academic anesthesiology departments. Indeed, the ongoing decline in the physician-scientist workforce sparked the Director of NIH, Dr. Francis Collins, to convene the physician-scientist working group to provide recommendations to enhance its robustness and diversity. The field of anesthesiology lags behind in NIH funding, e.g., as compared to surgery or medicine departments. Yet, despite efforts to provide junior applicants with a competitive advantage, the critical transition from career development to independent investigator status, often referred to as “K2R”, remains a significant challenge, especially for women and investigators from underrepresented in medicine backgrounds. Currently, the typical model for a mentor/mentee relationship is conditional on physical proximity. COR-PM challenges this status quo, by proposing mentees from around the US to lead a cross-institutional mentoring effort, that will be independent of the physical location of mentee and mentor. To achieve the conference’s objectives, the investigators have designed a steering group comprised of 25 junior investigators from across the US, advised by an international eight-member senior advisory panel comprised of independent investigators with a track record of success in clinical cardiovascular outcomes research. Using a “By Mentees – With Mentors – For Mentees” paradigm, the investigators propos three specific aims. Aim 1: Organize the 2022 Cardiovascular Outcomes Research in Perioperative Medicine - COR-PM to advance clinical outcomes research in cardiovascular medicine within the T2-T4 translational spectrum. Aim 2: Provide mentorship capacity for junior investigators by providing tangible mentoring to attendees through pairing mentees with mentors across institutions. Aim 3: Create an inclusive and welcoming conference atmosphere by enhancing diversity and in all aspects of conference planning and implementation. The expected outcome of this conference is for participants to gain knowledge in the area of perioperative cardiovascular outcomes research and benefit from establishing mentoring relationships outside of their respective home institutions. COR-PM will thereby have an immediate and positive impact.