Neurovascular Consequences of Inhaled Uranium Mine-Site Dust Exposure
吸入铀矿场粉尘暴露对神经血管的影响
基本信息
- 批准号:10392427
- 负责人:
- 金额:$ 24.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-15 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdvisory CommitteesAirborne Particulate MatterArizonaArsenicArterial Fatty StreakAutomobile DrivingBehaviorBehavioralBiomedical ResearchBlood - brain barrier anatomyBlood CirculationBlood VesselsCardiovascular DiseasesCarotid ArteriesCarotid Artery PlaquesCommunication ResearchCommunitiesDataDevelopmentDustEndothelial CellsEndotheliumEnvironmental ExposureEnvironmental HealthEnvironmental PollutionExposure toExtravasationFunctional disorderFutureGasesGenerationsGoalsHealthHealth SciencesHeavy MetalsHomeImpairmentIn VitroIncidenceInflammationInflammatoryInflammatory ResponseIngestionInhalationInhalation ExposureInterventionLaboratoriesLeadLinkLungMagnetic Resonance ImagingMentorshipMetalsMiningNavajoNeurologicNew MexicoNickelOutcomeParticulateParticulate MatterPathologicPathologyPathway interactionsPharmacy (field)PlantsPopulationRadialRecording of previous eventsResearchResearch InfrastructureResearch PersonnelResearch ProposalsResource SharingRho-associated kinaseRoleSeriesSerumSiteSouthwestern United StatesStrokeTechniquesThrombusTissuesTransient Ischemic AttackTransition ElementsUniversitiesUraniumVanadiumVascular DiseasesWorkair quality regulationarmbasebrain parenchymaburden of illnesscareercerebrovasculardrinking waterendothelial dysfunctionexposure routein vivomorris water mazemouse modelnervous system disorderneuroimagingneuroinflammationneuropathologyneurovascularneurovascular unitparticleplaque lesionpreventremediationresponserhosupportive environmenttoxic metaltribal communitywasting
项目摘要
PROJECT SUMMARY
Corporate uranium mines were established in the Southwestern United States from the 1940s-1980s, leaving
behind poorly remediated sites near surrounding residential homes. Inhaled, mine-site derived PM has been
associated with an increase in serum inflammatory potential and subsequent vascular disease. The PM arising
from these uranium mines tends to be high in specific toxic metals including vanadium, uranium, and often
nickel and arsenic. The full scope of systemic health effects following inhaled mine-site derived PM is
unknown, but such inflammatory impacts to the neurovasculature could promote neurological diseases and the
elucidation of such mechanisms has yet to be discerned. Therefore, the primary objective of this research
proposal is to develop a deeper understanding of the mechanistic, causal basis for mine-site derived PM-
induced neurovascular dysfunction. In preliminary studies, I have observed that mine site PM is more acutely
toxic to the lungs and systemic vasculature compared to regional background PM. Furthermore, similar studies
of inhaled particulates and gases demonstrate a BBB dysfunction that can drive neuroinflammatory outcomes.
Therefore, my specific aims will serve three primary objectives: 1) to further explore neurovascular responses
following mine-site derived PM exposure using state-of-the art mobile laboratory AirCARE 1 2) to determine
the contribution of the Rho A/Rho kinase pathway on neurovascular dysfunction following mine-site derived PM
exposure and 3) to examine the ultimate impact of these outcomes on long-term neuropathology and behavior.
This project will serve as a five-year platform for my transition to independence. The University of New Mexico
(UNM) offers a supportive environment where investigators can take advantage of several shared resources. I
will take full advantage of the outstanding facilities at the University of New Mexico Health Sciences Center,
including the Biomedical Research and Integrative Neuroimaging Center (BRaIN), where the MRI, Morris
Water Maze and Radial Arm Maze are housed. Data from these studies will ultimately lead to essential
information pertinent to Southwestern populations in close proximity to abandoned uranium mines, as well as
governing agencies involved in air-quality regulations.
项目总结
项目成果
期刊论文数量(0)
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Katherine Zychowski其他文献
Katherine Zychowski的其他文献
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{{ truncateString('Katherine Zychowski', 18)}}的其他基金
Systemic Implications and Novel Mechanisms of Circulating Extracellular Vesicles Following Inhaled Exposures
吸入暴露后循环细胞外囊泡的系统影响和新机制
- 批准号:
10733648 - 财政年份:2023
- 资助金额:
$ 24.62万 - 项目类别:
Particulate Matter-Induced Pulmonary Exosomes and the Lung-Brain Axis
颗粒物诱导的肺外泌体和肺脑轴
- 批准号:
10302568 - 财政年份:2021
- 资助金额:
$ 24.62万 - 项目类别:
Particulate Matter-Induced Pulmonary Exosomes and the Lung-Brain Axis
颗粒物诱导的肺外泌体和肺脑轴
- 批准号:
10451822 - 财政年份:2021
- 资助金额:
$ 24.62万 - 项目类别:
Neurovascular Consequences of Inhaled Uranium Mine-Site Dust Exposure
吸入铀矿场粉尘暴露对神经血管的影响
- 批准号:
10164782 - 财政年份:2020
- 资助金额:
$ 24.62万 - 项目类别:
Neurovascular Consequences of Inhaled Uranium Mine-Site Dust Exposure
吸入铀矿场粉尘暴露对神经血管的影响
- 批准号:
10094731 - 财政年份:2020
- 资助金额:
$ 24.62万 - 项目类别:
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