Research Support Core D: Clinical and Behavioral Services
研究支持核心 D:临床和行为服务
基本信息
- 批准号:10632099
- 负责人:
- 金额:$ 73.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-15 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAccident and Emergency departmentAreaBackBehavior TherapyBehavioralBiologicalBiological Specimen BanksBiopsyCaringCerebrospinal FluidCharacteristicsClientClinicClinicalClinical DataClinical ResearchClinical TrialsCollectionColonCommunicable DiseasesCommunity HealthcareCommunity OutreachCountyCounty HospitalsDataData CollectionDatabasesDiseaseElectronic Health RecordEmergency Department patientFecesFundingFutureHIVHIV SeronegativityHealthHealth Services ResearchHospitalizationHospitalsIndigent CareIndividualInpatientsInstitutionLaboratoriesLeadershipLinkLongitudinal cohortMedical EducationMedical centerMental HealthMissionNaloxoneNational Institute of Drug AbuseNeedle-Exchange ProgramsNursing ResearchObservational StudyOhioOpioidParticipantPatient CarePatient Outcomes AssessmentsPatientsPeripheral Blood Mononuclear CellPersonsPlasmaPopulationPrimary CareProviderPsychosocial Assessment and CarePublic HealthRNA purificationRecording of previous eventsRecovery SupportRectumRegistriesReportingResearchResearch ActivityResearch AssistantResearch PersonnelResearch Project GrantsResearch SubjectsResearch SupportResourcesRiskRuralSafetySamplingSerumServicesSexually Transmitted DiseasesSpecimenSuboxoneSubstance Use DisorderSwabSystemTeaching HospitalsTime StudyTonsillar TissueTrainingTranslational ResearchUniversitiesUrineVaginaVulnerable PopulationsWhole Bloodaddictionbehavioral studybiobankclinical databasecohortcombatdata structuredesignepidemiology studyexperiencehealth organizationimplementation sciencemarginalized populationmedical specialtiesmedication-assisted treatmentmental health organizationmotivational enhancement therapyopioid epidemicpeer supportpopulation healthpre-exposure prophylaxisprogramsrecruitrectalrepositorysample collectionscreeningsubstance usesuburbsuccesstooltranslational studytrauma centersvirtualwaiver
项目摘要
Project Summary Core D – Clinical and Behavioral Services Core
The Clinical and Behavioral Services Core D furthers the scientific mission of the Case
Western Reserve University Center for Excellence on the Impact of Substance Use on
HIV by providing a uniform, broadly available resource to gain access to subjects, specimens,
and collected data for basic, translational, clinical, epidemiological, behavioral, and psychosocial
studies of HIV disease. Currently, the Core has a searchable registry with longitudinal history of
virtually all HIV-infected patients followed in the MetroHealth System (MHS) ID clinic, the largest
HIV provider in Northeast Ohio, and will establish a biorepository linked to this clinical data.
Core D will enable investigators to conduct studies that require access to populations that are
typically difficult to reach, recruit, and retain. The Database will leverage the robust electronic
health record (EHR) that has been in place since 1999 at MHS. The EHR has embedded search
tools to (i) enable population health research, (ii) identify subjects for research and registries,
(iii) track populations, and (iv) retrieve extensive clinical information with data extending back to
1999. The Specimen Repository will be linked to the Database and offers researchers ready
access to stored samples complete with comprehensive, longitudinal, clinical, patient reported
outcomes, behavioral, and laboratory data. Core D will leverage existing studies of patients who
use illicit substances to develop a comprehensive database and specimen repository of persons
with substance use disorder and HIV and then expand to include HIV-negative at-risk for HIV
substance using individuals. The linked repository will include a robust expansive program for
longitudinal semi-annual collection of peripheral blood mononuclear cells, plasma, serum, stool,
rectal swabs, vaginal swabs, and urine. The repository will also collect and store tonsillar tissue,
CSF, and colonic biopsies. Participants will receive client centered assistance to treat addiction
from staff trained to use motivational interviewing. Core D will integrate public and mental health
activities in Northeast Ohio regarding persons with HIV and Substance Use Disorder through
clinical and community outreach with our neighboring public and mental health organizations,
that include urban (Cleveland), suburban (Cuyahoga), and suburban/rural (Lorain) populations.
Finally, Core D leadership will assist investigators in formulating research questions that take
full advantage of the clinical Database and specimen Repository, while avoiding pitfalls and
potential biases that result from incomplete understanding of the data structure, patient-related
data, and patient characteristics.
项目概要核心D -临床和行为服务核心
临床和行为服务核心D进一步推进了病例的科学使命
西储大学卓越中心对物质使用的影响
通过提供统一的、广泛可用的资源来获取受试者、标本,
并收集了基础、转化、临床、流行病学、行为和心理社会的数据
艾滋病的研究。目前,核心有一个可搜索的登记处,
几乎所有的艾滋病毒感染者都在大都会卫生系统(MHS)ID诊所,
艾滋病毒提供商在东北俄亥俄州,并将建立一个生物储存库链接到这个临床数据。
核心D将使研究人员能够进行需要接触以下人群的研究:
通常难以接触、招募和留住。数据库将利用强大的电子
自1999年以来一直在MHS的健康记录(EHR)。EHR嵌入了搜索
工具,以㈠使人口健康研究,㈡确定研究和登记的主题,
(iii)跟踪人群,以及(iv)检索广泛的临床信息,数据可追溯到
1999.标本库将与数据库相连,为研究人员提供
访问存储的样本,包括全面的、纵向的、临床的、患者报告的
结果、行为和实验室数据。核心D将利用现有的患者研究,
使用非法物质建立一个全面的数据库和个人样本库
患有药物使用障碍和艾滋病毒的人,然后扩展到包括艾滋病毒阴性的艾滋病毒高危人群
物质使用者。链接库将包括一个强大的扩展程序,
每半年纵向采集外周血单个核细胞、血浆、血清、粪便,
直肠拭子阴道拭子和尿液储存库还将收集和储存扁桃体组织,
脑脊液和结肠活检。参与者将获得以客户为中心的援助,以治疗成瘾
接受过激励式面试培训的员工核心D将整合公共卫生和精神卫生
在俄亥俄州东北部开展的关于艾滋病毒和物质使用障碍患者的活动,
临床和社区外展与我们邻近的公共和精神卫生组织,
包括城市(克利夫兰)、郊区(凯霍加)和郊区/农村(洛兰)人口。
最后,核心D领导层将协助研究人员制定研究问题,
充分利用临床数据库和标本库,同时避免陷阱,
对数据结构的不完全理解导致的潜在偏倚,患者相关
数据和患者特征。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANN K AVERY其他文献
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{{ truncateString('ANN K AVERY', 18)}}的其他基金
Randomized Control Trial of Positive Peers mHealth app as a clinic-based intervention to optimize HIV outcomes among young, minority persons living with HIV
积极同伴移动医疗应用程序的随机对照试验作为一种基于临床的干预措施,以优化年轻的少数族裔艾滋病毒感染者的艾滋病毒结果
- 批准号:
10819912 - 财政年份:2023
- 资助金额:
$ 73.19万 - 项目类别:
Research Support Core D: Clinical and Behavioral Services
研究支持核心 D:临床和行为服务
- 批准号:
10304586 - 财政年份:2021
- 资助金额:
$ 73.19万 - 项目类别: