Research Support Core D: Clinical and Behavioral Services

研究支持核心 D：临床和行为服务

• 批准号: 10304586
• 负责人: ANN K AVERY
• 金额: $ 73.97万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10304586
• 关键词: AIDS prevention; Accident and Emergency department; Area; Back; Behavior Therapy; Behavioral; Biological; Biological Specimen Banks; Biopsy; Caring; Cerebrospinal Fluid; Characteristics; Client; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collection; Communicable Diseases; Communities; Community Outreach; County; County Hospitals; Data; Data Collection; Databases; Disease; Electronic Health Record; Emergency Department patient; Feces; Funding; Future; HIV; HIV Seronegativity; Health; Health Services Research; Hospitals; Indigent Care; Individual; Inpatients; Institution; Investigation; Laboratories; Leadership; Link; Longitudinal cohort; Medical Education; Medical center; Mental Health; Mission; Naloxone; National Institute of Drug Abuse; Needle-Exchange Programs; Nursing Research; Observational Study; Ohio; Opioid; Participant; Patient Care; Patient Education; Patient Outcomes Assessments; Patients; Peripheral Blood Mononuclear Cell; Persons; Plasma; Population; Primary Health Care; Provider; Psychosocial Assessment and Care; Public Health; RNA purification; Recording of previous events; Recovery; Registries; Reporting; Research; Research Activity; Research Assistant; Research Personnel; Research Project Grants; Research Subjects; Research Support; Resources; Risk; Rural; Safety; Sampling; Services; Sexually Transmitted Diseases; Specimen; Suboxone; Substance Use Disorder; Swab; System; Teaching Hospitals; Time Study; Tonsillar Tissue; Training; Translational Research; Universities; Urine; Vagina; Vulnerable Populations; Whole Blood; addiction; behavioral study; biobank; clinical database; cohort; combat; data structure; design; education research; epidemiology study; experience; health organization; implementation science; marginalized population; medical specialties; medication-assisted treatment; mental health organization; motivational enhancement therapy; opioid epidemic; peer support; population health; pre-exposure prophylaxis; programs; recruit; rectal; repository; sample collection; screening; substance use; suburb; success; tool; translational study; trauma centers; virtual; waiver

Project Summary Core D – Clinical and Behavioral Services Core The Clinical and Behavioral Services Core D furthers the scientific mission of the Case Western Reserve University Center for Excellence on the Impact of Substance Use on HIV by providing a uniform, broadly available resource to gain access to subjects, specimens, and collected data for basic, translational, clinical, epidemiological, behavioral, and psychosocial studies of HIV disease. Currently, the Core has a searchable registry with longitudinal history of virtually all HIV-infected patients followed in the MetroHealth System (MHS) ID clinic, the largest HIV provider in Northeast Ohio, and will establish a biorepository linked to this clinical data. Core D will enable investigators to conduct studies that require access to populations that are typically difficult to reach, recruit, and retain. The Database will leverage the robust electronic health record (EHR) that has been in place since 1999 at MHS. The EHR has embedded search tools to (i) enable population health research, (ii) identify subjects for research and registries, (iii) track populations, and (iv) retrieve extensive clinical information with data extending back to 1999. The Specimen Repository will be linked to the Database and offers researchers ready access to stored samples complete with comprehensive, longitudinal, clinical, patient reported outcomes, behavioral, and laboratory data. Core D will leverage existing studies of patients who use illicit substances to develop a comprehensive database and specimen repository of persons with substance use disorder and HIV and then expand to include HIV-negative at-risk for HIV substance using individuals. The linked repository will include a robust expansive program for longitudinal semi-annual collection of peripheral blood mononuclear cells, plasma, serum, stool, rectal swabs, vaginal swabs, and urine. The repository will also collect and store tonsillar tissue, CSF, and colonic biopsies. Participants will receive client centered assistance to treat addiction from staff trained to use motivational interviewing. Core D will integrate public and mental health activities in Northeast Ohio regarding persons with HIV and Substance Use Disorder through clinical and community outreach with our neighboring public and mental health organizations, that include urban (Cleveland), suburban (Cuyahoga), and suburban/rural (Lorain) populations. Finally, Core D leadership will assist investigators in formulating research questions that take full advantage of the clinical Database and specimen Repository, while avoiding pitfalls and potential biases that result from incomplete understanding of the data structure, patient-related data, and patient characteristics.

项目摘要核心D - 临床和行为服务核心 临床和行为服务核心核心进一步加强了该案的科学任务 西部储备大学对物质使用对物质影响的卓越中心 通过提供统一的，广泛可用的资源来访问主题，标本， 并收集了基本，翻译，临床，流行病学，行为和社会心理的数据 艾滋病毒疾病的研究。目前，核心具有可搜索的注册表，具有纵向历史的 实际上，所有艾滋病毒感染的患者遵循Metrohealth系统（MHS）ID诊所，最大的患者 俄亥俄州东北部的艾滋病毒提供商，将建立与此临床数据相关的生物座席。 核心D将使调查人员能够进行需要访问人口的研究 通常难以到达，招募和保留。数据库将利用强大的电子 自1999年以来在MHS以来一直存在的健康记录（EHR）。 EHR已嵌入搜索 （i）启用人口健康研究的工具，（ii）确定研究和注册表的科目， （iii）跟踪人群，（iv）检索广泛的临床信息，数据延伸到 1999年。标本存储库将链接到数据库，并为研究人员提供准备 访问储存的样品，并提供综合，纵向，临床，患者报告 结果，行为和实验室数据。核心D将利用现有研究的患者研究 使用非法物质来开发人民的全面数据库和标本存储库 患有药物使用障碍和HIV，然后扩展到包括HIV感染HIV的HIV阴性 使用个人的物质。链接的存储库将包括一个强大的广泛计划 外周血单核细胞的纵向半年度收集，血浆，血清，粪便， 直肠拭子，阴道拭子和尿液。存储库还将收集和存储扁桃体组织， CSF和结肠活检。参与者将获得以客户为中心的帮助来治疗成瘾 从受过训练的员工到使用动机面试。核心D将整合公共和心理健康 俄亥俄州东北部关于艾滋病毒和药物使用障碍的活动 与我们邻近的公共和心理健康组织的临床和社区宣传， 其中包括城市（克利夫兰），郊区（Cuyahoga）和郊区/农村（Lorain）人口。 最后，核心D领导将协助调查人员提出研究问题 临床数据库和标本存储库的充分优势，同时避免陷阱和 与患者有关的数据结构不完全理解而导致的潜在偏见 数据和患者特征。