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Research Support Core D: Clinical and Behavioral Services

研究支持核心 D：临床和行为服务

基本信息

批准号：
10304586
负责人：
ANN K AVERY
金额：
$ 73.97万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10304586
关键词：
AIDS prevention Accident and Emergency department Area Back Behavior Therapy Behavioral Biological Biological Specimen Banks Biopsy Caring Cerebrospinal Fluid Characteristics Client Clinic Clinical Clinical Data Clinical Research Clinical Trials Collection Communicable Diseases Communities Community Outreach County County Hospitals Data Data Collection Databases Disease Electronic Health Record Emergency Department patient Feces Funding Future HIV HIV Seronegativity Health Health Services Research Hospitals Indigent Care Individual Inpatients Institution Investigation Laboratories Leadership Link Longitudinal cohort Medical Education Medical center Mental Health Mission Naloxone National Institute of Drug Abuse Needle-Exchange Programs Nursing Research Observational Study Ohio Opioid Participant Patient Care Patient Education Patient Outcomes Assessments Patients Peripheral Blood Mononuclear Cell Persons Plasma Population Primary Health Care Provider Psychosocial Assessment and Care Public Health RNA purification Recording of previous events Recovery Registries Reporting Research Research Activity Research Assistant Research Personnel Research Project Grants Research Subjects Research Support Resources Risk Rural Safety Sampling Services Sexually Transmitted Diseases Specimen Suboxone Substance Use Disorder Swab System Teaching Hospitals Time Study Tonsillar Tissue Training Translational Research Universities Urine Vagina Vulnerable Populations Whole Blood addiction behavioral study biobank clinical database cohort combat data structure design education research epidemiology study experience health organization implementation science marginalized population medical specialties medication-assisted treatment mental health organization motivational enhancement therapy opioid epidemic peer support population health pre-exposure prophylaxis programs recruit rectal repository sample collection screening substance use suburb success tool translational study trauma centers virtual waiver

项目摘要

Project Summary Core D – Clinical and Behavioral Services Core The Clinical and Behavioral Services Core D furthers the scientific mission of the Case Western Reserve University Center for Excellence on the Impact of Substance Use on HIV by providing a uniform, broadly available resource to gain access to subjects, specimens, and collected data for basic, translational, clinical, epidemiological, behavioral, and psychosocial studies of HIV disease. Currently, the Core has a searchable registry with longitudinal history of virtually all HIV-infected patients followed in the MetroHealth System (MHS) ID clinic, the largest HIV provider in Northeast Ohio, and will establish a biorepository linked to this clinical data. Core D will enable investigators to conduct studies that require access to populations that are typically difficult to reach, recruit, and retain. The Database will leverage the robust electronic health record (EHR) that has been in place since 1999 at MHS. The EHR has embedded search tools to (i) enable population health research, (ii) identify subjects for research and registries, (iii) track populations, and (iv) retrieve extensive clinical information with data extending back to 1999. The Specimen Repository will be linked to the Database and offers researchers ready access to stored samples complete with comprehensive, longitudinal, clinical, patient reported outcomes, behavioral, and laboratory data. Core D will leverage existing studies of patients who use illicit substances to develop a comprehensive database and specimen repository of persons with substance use disorder and HIV and then expand to include HIV-negative at-risk for HIV substance using individuals. The linked repository will include a robust expansive program for longitudinal semi-annual collection of peripheral blood mononuclear cells, plasma, serum, stool, rectal swabs, vaginal swabs, and urine. The repository will also collect and store tonsillar tissue, CSF, and colonic biopsies. Participants will receive client centered assistance to treat addiction from staff trained to use motivational interviewing. Core D will integrate public and mental health activities in Northeast Ohio regarding persons with HIV and Substance Use Disorder through clinical and community outreach with our neighboring public and mental health organizations, that include urban (Cleveland), suburban (Cuyahoga), and suburban/rural (Lorain) populations. Finally, Core D leadership will assist investigators in formulating research questions that take full advantage of the clinical Database and specimen Repository, while avoiding pitfalls and potential biases that result from incomplete understanding of the data structure, patient-related data, and patient characteristics.

核心D -临床和行为服务核心