Techniques Development

技术开发

• 批准号: 10632050
• 负责人: MARK S GEORGE
• 金额: $ 14.95万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632050
• 关键词: Address; Brain; Childhood; Clinical Research; Clinical Trials; Communities; Development; Dose; Elements; Enhancement Technology; Equilibrium; Evaluation; Evidence based intervention; Feedback; Funding; Future; Gait; Goals; Individual; Intervention; Knowledge; Leg; Mainstreaming; Mental Depression; Methodology; Methods; Motor; Multi-Institutional Clinical Trial; Neurologic; Operant Conditioning; Performance; Population; Process; Psychiatry; Rehabilitation therapy; Reproducibility; Research; Research Personnel; Research Technics; Resources; Series; Site; Spinal Cord; Standardization; Techniques; Technology Development Study; Testing; Translating; United States National Institutes of Health; Work; catalyst; community engagement; design; effective therapy; evidence base; functional magnetic resonance imaging/electroencephalography; improved; method development; neurophysiology; neuroregulation; noninvasive brain stimulation; novel therapeutics; rehabilitation research; research and development; research study; response; technique development; technology development; technology/technique; tool; translational neuroscience

TECHNIQUES DEVELOPMENT – PROJECT SUMMARY / ABSTRACT The overarching goal of the National Center of NM4R is to impact multiple RPR priorities by increasing rehabilitation research workforce access to NM4R approaches and supporting rigorous clinical research to translate them into effective, evidence-based rehabilitation interventions. A critical element to achieve this is to develop, test and share new techniques and enhanced technologies in neuromodulation for rehabilitation (NM4R – the mechanisms and use of non-invasive brain stimulation and operant conditioning of brain and spinal cord networks integrated with rehabilitation principles). The Techniques Development component seeks to develop, adapt and/or validate core research techniques, tools and other resources designed to improve the accessibility, applicability, utility, validity and feasibility of these approaches for the NM4R research community. It is our primary research vehicle to translate promising NM4R approaches into effective, evidence-based rehabilitation interventions. The field of NM4R research is dynamic with methodology continually being refined. To advance techniques and technology in NM4R, we have the following Specific Aims. AIM 1.Increase rigor in NM4R design, methods and clinical trials through methods and technology development studies. Very important methods and technology development studies are rarely “flashy” enough or large enough on their own for NIH funding. Yet they are crucial for the translation of neuroscience ideas into rehabilitation treatments, especially in the context of clinical trials. Tech Development currently acts as a catalyst for NM4R research by addressing pressing questions in the field such as how to develop TMS neurophysiological techniques most relevant to the leg when studying gait and balance. AIM 2. Perform key research to translate NM4R approaches into evidence-based interventions. Translating promising approaches into effective treatments usually requires key research studies to move beyond concepts. An example is the ongoing tech development project to determine how to individually dose tDCS studies, in the same way individual motor threshold is used to dose rTMS studies. AIM 3. Develop emerging NM techniques into NM4R tools. Currently rehabilitation lags behind psychiatry in developing new NM based tools. We propose to introduce emerging techniques into tools for NM4R much more quickly. Successful examples include taVNS and combined TMS-fMRI-EEG techniques.

技术开发 - 项目摘要 /摘要 NM4R国家中心的总体目标是通过增加来影响多个RPR优先级 康复研究工作人员进入NM4R方法并支持严格的临床研究 将它们转化为有效的，基于证据的康复干预措施。实现这一目标的关键要素是 开发，测试和共享康复神经调节中的新技术和增强技术（NM4R） - 非侵入性大脑刺激的机制和使用以及大脑和脊髓的工作条件 与康复原则集成的网络。技术开发组成部分试图开发， 适应和/或验证核心研究技术，工具和其他旨在改善可访问性的资源， 这些方法适用于NM4R研究社区的适用性，效用，有效性和可行性。这是我们的 将承诺NM4R方法转化为有效的，基于证据的康复的主要研究工具 干预措施。 NM4R研究领域是动态的，方法论不断完善。前进 NM4R的技术和技术，我们具有以下特定目标。目标1.在NM4R中严格施加严格 通过方法和技术开发研究设计，方法和临床试验。非常重要 方法和技术开发研究很少“浮华”或足够大的NIH 资金。然而，它们对于将神经科学思想转化为康复治疗至关重要，尤其是在 临床试验的背景。技术开发目前通过解决NM4R研究的催化剂 在该领域中施加问题，例如如何开发与该技术最相关的TMS神经生理技术 研究步态和平衡时的腿。目标2。执行关键研究以将NM4R方法转化为 基于证据的干预措施。将承诺方法转化为有效的治疗通常需要关键 研究超越概念的研究。一个正在进行的技术开发项目的一个例子旨在确定 如何单独剂量的TDCS研究，就像单个运动阈值相同的方式用于剂量RTMS研究。 目标3。将新兴的NM技术开发到NM4R工具中。目前的康复落后于精神病学 开发新的基于NM的工具。我们建议将新兴技术引入更多的NM4R工具 迅速地。成功的示例包括TAVN和TMS-FMRI-EEG技术。