Deploying Intracortical Electrode Arrays to Record and Stimulate in a Tissue Volume
部署皮质内电极阵列以在组织体积中进行记录和刺激
基本信息
- 批准号:10636123
- 负责人:
- 金额:$ 47.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAccelerationAgingAnimalsAreaBrainCellsChronicClinicalCollaborationsConeDataDevice DesignsDevicesElasticityElectrodesElementsEncapsulatedExposure toFailureForeign BodiesFutureGene ExpressionGeometryGoalsGoldHistologicHourImplantLocationMapsMeasuresMichiganMicroelectrodesMicrofabricationModelingModulusMonitorMotor CortexMusNeurosciencesPatternPerformancePhysiologicalPositioning AttributeProteinsProteomicsPublicationsPublishingRecording of previous eventsRecordsResistanceResolutionSepharoseShapesSiteStructureTechnologyTimeTinTissuesTraumaWaterWorkbrain tissuebrain volumeclinical applicationcrosslinkdesignexperimental studyfabricationimplantable deviceimplantationimprovedinterestliquid crystal polymermechanical propertiesmeterneuralneural circuitneuroinflammationresponsetranscriptomicsuptake
项目摘要
Project Summary
The overall goal of this project is to develop a new intracortical electrode array where a flat device is inserted
that then deploys microelectrodes at controlled distances within a volume of tissue. This deployable neural
interface will overcome two critical limitations associated with recording and stimulation of the cortex: 1) each
insertion only leads to placement of electrodes at a point or along a linear path within brain tissue and 2) the
recording performance is reduced by adverse tissue response. This work will result in deployable electrode
arrays using shape-changing liquid crystal polymer (LCP) substrates with microelectrodes patterned by
photolithography. The LCP substrates remain flat during fabrication and processing, then deploy after
implantation to predetermined locations that are up to 200 µm away from the implantation site. The central
premise of this work is that electrode deployment from a single insertion can enable volumetric
placement of microelectrodes in mouse cortex with viable recording and stimulation capability for over
four months. The team’s published and preliminary data demonstrate the feasibility of creating deployable
electrode arrays using shape-changing liquid crystal polymer (LCP) substrates with microelectrodes patterned
by photolithography. To realize this premise, three specific aims are proposed: 1) Fabricate and characterize
deployable electrode arrays, 2) Characterize the foreign body response elicited by deploying microelectrode
arrays, and 3) Characterize deploying microelectrode arrays by chronic recording and measuring
electrochemical performance of the electrodes. The team brings together the necessary expertise in materials
and microfabrication (PI Ware) and neural interface design and characterization (Co-I Pancrazio), and
histological response to implanted devices (Co-I Capadona).
项目摘要
这个项目的总体目标是开发一种新的皮质内电极阵列,其中插入了一个平板设备
然后在一定体积的组织内以可控的距离部署微电极。这种可展开的神经
界面将克服与皮层记录和刺激相关的两个关键限制:1)每个限制
插入只能导致将电极放置在脑组织内的某个点或沿线性路径,以及2)
不良组织反应会降低记录性能。这项工作将产生可展开的电极
使用形状改变的液晶聚合物(LCP)基板的阵列,其中微电极由
光刻技术。LCP基板在制造和加工过程中保持平坦,然后在
植入到距离植入部位最远200微米的预定位置。中环
这项工作的前提是从一次插入的电极部署可以实现体积
可持续记录和刺激的小鼠大脑皮质微电极的放置
四个月。该团队公布的初步数据证明了创建可部署的
使用具有图案化微电极的形状变化的液晶聚合物(LCP)基板的电极阵列
通过光刻技术。为了实现这一前提,提出了三个具体目标:1)虚构和刻画
可展开电极阵列,2)表征通过展开微电极引起的异物反应
3)通过慢性记录和测量来表征部署的微电极阵列
电极的电化学性能。该团队汇集了材料方面的必要专业知识。
和微制造(PI Ware)和神经接口设计和表征(Co-I Pancrazio),以及
植入装置的组织学反应(Co-I Capadona)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Taylor H Ware其他文献
Taylor H Ware的其他文献
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{{ truncateString('Taylor H Ware', 18)}}的其他基金
Engineered Living Materials for the Delivery of Engineered Probiotics and Therapeutics
用于输送工程益生菌和治疗药物的工程活性材料
- 批准号:
10644157 - 财政年份:2022
- 资助金额:
$ 47.24万 - 项目类别:
Liquid Crystal Elastomer as a Dynamic Treatment of Incontinence in Women
液晶弹性体作为女性失禁的动态治疗方法
- 批准号:
9808898 - 财政年份:2019
- 资助金额:
$ 47.24万 - 项目类别:
Liquid Crystal Elastomer as a Dynamic Treatment of Incontinence in Women
液晶弹性体作为女性失禁的动态治疗方法
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10256730 - 财政年份:2019
- 资助金额:
$ 47.24万 - 项目类别:
Liquid Crystal Elastomer as a Dynamic Treatment of Incontinence in Women
液晶弹性体作为女性失禁的动态治疗方法
- 批准号:
10225852 - 财政年份:2019
- 资助金额:
$ 47.24万 - 项目类别:
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