课题基金 / 基金详情

A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder

A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
前额重复经颅磁刺激(rTMS)治疗大麻使用障碍的初步研究
批准号:
10414732
负责人:
Gregory Sahlem
金额:
$13.93万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-01 至 2022-12-31

项目摘要

项目成果

Gregory Sahlem的其他基金

相似基金

相关文献

中文摘要
翻译
项目摘要/摘要:
英文摘要
Project Summary / Abstract: A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder. Cannabis use disorder (CUD) is a common condition with few validated treatments and, to date, no FDA- approved medications. Subsequently, providers have few options to offer treatment seekers. An expanding literature base suggests that a single treatment of excitatory repetitive Transcranial Magnetic stimulation (rTMS) applied to the dorsolateral pre-frontal cortex (DLPFC) may temporarily reduce drug cue induced craving across substance use disorders. Two recent clinical trials suggest that delivering a course of multiple rTMS treatments holds promise as a potential treatme nt for tobacco and cocaine use disorders. Consistent with the findings in addictions, in Major Depressive Disorder a single treatment of rTMS has little if any mood effect; however repeated treatments result in clinically meaningful improvement and remissi on from depression in a substantial number of depressed patients. The candidate and mentorship team recently completed a laboratory-based trial demonstrating that a single treatment of rTMS is safe, tolerable, and feasible in non-treatment seeking cannabis use disordered participants. Additionally, rTMS reduced cannabis cue-induced craving. Given these promising preliminary findings, it is possible that a full course of rTMS would have a larger effect on craving and an effect on cannabis use. In this application for a career development award, the candidate proposes to determine if a course of rTMS treatments applied to the DLPFC can result in reduced cannabis cue-induced craving (Aim1) and cue reactivity in reward structures during an fMRI paradigm (Aim2) in treatment seeking cannabis use disordered individuals. Additionally, he will determine if a course of rTMS reduces cannabis use (Exploratory Aim). Development of a novel, effective treatment for CUD would have the potential of helping the e stimated one million cannabis using Americans that seek treatment each year. Of note, rTMS is a treatment with few side effects, and it may focally target CUD’s pathophysiology.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1016/j.brs.2020.07.015
发表时间: 2020-09
期刊: Brain stimulation
影响因子: 7.7
作者: [Sahlem GL, McCall WV, Short EB, Rosenquist PB, Fox JB, Youssef NA, Manett AJ, Kerns SE, Dancy MM, McCloud L, George MS, Sackeim HA]
通讯作者: Sackeim HA
DOI: 10.1002/aur.2266
发表时间: 2020-03
期刊: AUTISM RESEARCH
影响因子: 4.7
作者: [Gwynette, McLeod Frampton, Lowe, Danielle W., Henneberry, Erin A., Sahlem, Gregory L., Wiley, Melanie Gail, Alsarraf, Hussam, Russo, Sarah Brice, Joseph, Jane E., Summers, Philipp M., Lohnes, Laura, George, Mark S.]
通讯作者: George, Mark S.
DOI: 10.1097/yct.0000000000000776
发表时间: 2021-12-01
期刊: The journal of ECT
影响因子: --
作者: [Youssef NA, George MS, McCall WV, Sahlem GL, Short B, Kerns S, Manett AJ, Fox JB, Dancy M, Cook D, Devries W, Rosenquist PB, Sackeim HA]
通讯作者: Sackeim HA
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
  • 批准号:
    10175987
  • 项目类别:
  • 资助金额:
    $19.35万
  • 财政年份:
    2017
  • 负责人:
    Gregory Sahlem
  • 依托单位:
国内基金
海外基金
Sitagliptin通过microbiota-gut-brain轴在2型糖尿病致阿尔茨海默样变中的脑保护作用机制
  • 批准号:
    81801389
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    21.0万元
  • 批准年份:
    2018
  • 负责人:
    田茗源
  • 依托单位:
平扫描数据导引的超低剂量Brain-PCT成像新方法研究
  • 批准号:
    81101046
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2011
  • 负责人:
    黄静
  • 依托单位: