A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
批准号:
10175987
负责人:
Gregory Sahlem
金额:
$19.35万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-07-01 至 2022-12-31
关键词:
AbstinenceAcuteAddressAdultAftercareAlcoholsAmericanAttentionBehavior TherapyBrainCannabisClinicalClinical TrialsCocaineCreatinineCross-Over StudiesCuesDataDevelopmentDiseaseDisease remissionDouble-Blind MethodFDA approvedFunctional Magnetic Resonance ImagingFunctional disorderGoalsHigh PrevalenceIndividualInterventionInvestigationK-Series Research Career ProgramsLaboratoriesLeftLiteratureMajor Depressive DisorderMeasuresMental DepressionMentorshipMoodsNicotineParticipantPatient Self-ReportPatientsPharmaceutical PreparationsPopulationPrefrontal CortexPrevalenceProviderPublishingRandomizedResearchRewardsSignal TransductionSiteSmokerStructureSubstance Use DisorderTechniquesTestingTimeTobacco useTrainingTranslatingUnited StatesUrineWorkaddictionalcohol use disorderbaseblood oxygenation level dependent responsecareercocaine usecravingcue reactivitydepressed patienteffective therapyinnovationmarijuana usemarijuana use disordermotivational enhancement therapynicotine usenovelrepetitive transcranial magnetic stimulationsham-controlled studyside effectstandard of caretobacco abstinencetool
中文摘要
项目摘要/摘要:
大麻使用障碍(CUD)是一种常见的疾病,几乎没有有效的治疗方法,到目前为止,还没有FDA-
批准的药物。因此,提供者几乎没有选择为寻求治疗的人提供服务。
一项不断扩大的文献基础表明,兴奋性重复经颅磁力的单一治疗
刺激(RTMS)背外侧前额叶皮质(DLPFC)可暂时减少药物线索
在物质使用障碍中诱发渴求。最近的两项临床试验表明,提供一个疗程的
多种rTMS疗法有望成为烟草和可卡因使用障碍的潜在治疗方法。
与成瘾的研究结果一致,在重度抑郁障碍中,rTMS的单一治疗几乎没有
任何情绪影响;然而,重复治疗导致临床上有意义的改善和缓解
抑郁症患者中有相当一部分是抑郁症患者。
候选人和指导团队最近完成了一项基于实验室的试验,证明了一种单一的
对于寻求大麻使用障碍的非治疗患者,rTMS的治疗是安全、耐受和可行的。
参与者。此外,rTMS减少了大麻线索诱导的渴望。鉴于这些有希望的初步结果
研究发现,一个完整疗程的rTMS可能会对渴望有更大的影响,并对
吸食大麻。
在这份职业发展奖的申请中,应聘者建议确定一门rtms课程是否
应用于DLPFC的治疗可以减少大麻线索诱导的渴望(Aim1)和线索反应性
在寻找大麻的治疗中,在fMRI范式(AIM2)期间的奖励结构中,使用紊乱的个体。
此外,他将确定一个疗程的rTMS是否减少大麻的使用(探索性目标)。开发一种
新的有效的治疗方法将有可能帮助大约100万吸食大麻的人
每年寻求治疗的美国人。值得注意的是,rTMS是一种副作用很小的治疗方法,它可能集中在
目标是CUD的病理生理学。
英文摘要
Project Summary / Abstract:
Cannabis use disorder (CUD) is a common condition with few validated treatments and, to date, no FDA-
approved medications. Subsequently, providers have few options to offer treatment seekers.
An expanding literature base suggests that a single treatment of excitatory repetitive Transcranial Magnetic
stimulation (rTMS) applied to the dorsolateral pre-frontal cortex (DLPFC) may temporarily reduce drug cue
induced craving across substance use disorders. Two recent clinical trials suggest that delivering a course of
multiple rTMS treatments holds promise as a potential treatment for tobacco and cocaine use disorders.
Consistent with the findings in addictions, in Major Depressive Disorder a single treatment of rTMS has little if
any mood effect; however repeated treatments result in clinically meaningful improvement and remission from
depression in a substantial number of depressed patients.
The candidate and mentorship team recently completed a laboratory-based trial demonstrating that a single
treatment of rTMS is safe, tolerable, and feasible in non-treatment seeking cannabis use disordered
participants. Additionally, rTMS reduced cannabis cue-induced craving. Given these promising preliminary
findings, it is possible that a full course of rTMS would have a larger effect on craving and an effect on
cannabis use.
In this application for a career development award, the candidate proposes to determine if a course of rTMS
treatments applied to the DLPFC can result in reduced cannabis cue-induced craving (Aim1) and cue reactivity
in reward structures during an fMRI paradigm (Aim2) in treatment seeking cannabis use disordered individuals.
Additionally, he will determine if a course of rTMS reduces cannabis use (Exploratory Aim). Development of a
novel, effective treatment for CUD would have the potential of helping the estimated one million cannabis using
Americans that seek treatment each year. Of note, rTMS is a treatment with few side effects, and it may focally
target CUD's pathophysiology.
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会议论文
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
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批准号:10414732
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项目类别:
-
资助金额:$13.93万
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财政年份:2017
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负责人:Gregory Sahlem
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依托单位:
A Preliminary Investigation of Pre-Frontal repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
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批准号:9295291
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项目类别:
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资助金额:$20.0万
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财政年份:2017
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负责人:Gregory Sahlem
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依托单位:
海外基金