Planning the VICTORY (VIsual ComplicaTions Of PrematuRitY) Study

项目摘要 早产儿视网膜病变（ROP）是一种神经血管疾病，主要发生于极早产儿， 婴儿。国家眼科研究所（NEI）估计，每年有400至600名儿童成为合法的。 由于ROP而失明。该项目的目标是计划一项大型多中心队列研究，旨在收集 需要全面的社会、临床和生物标志物数据来进一步阐明 极低胎龄新生儿（ELGAN，<28周）的ROP和不良视力结局（AVO） 妊娠）。该项目的目标是（1）最后确定联合体并设立专家工作组 （2）制定研究方案和手册， 程序（MOP），以及（3）概述并进行初步和可行性研究。计划中的研究将有 多个创新元素，最重要的是（a）第一个多中心观察性研究，重点是 ROP/AVO，（B）出生后多个时间点的视网膜成像，（c）人工智能/机器学习 方法，（d）健康的社会决定因素，（e）产前和产后生物标志物测量，以及（f）视觉 和神经发育结果评估。

PROJECT SUMMARY Retinopathy of prematurity (ROP) is a neurovascular disorder that occurs mainly among extremely preterm infants. The National Eye Institute (NEI) estimates that every year between 400 and 600 children become legally blind due to ROP. The goal of this project is to plan a large, multicenter cohort study designed to gather comprehensive social, clinical, and biomarker data needed to further elucidate the etiology and pathogenesis of ROP and adverse visual outcomes (AVO) in extremely low gestational age newborns (ELGANs, <28weeks gestation). The aims of the project are (1) to finalize the consortium and create expert working groups (WGs) that will tackle the planning tasks in their area of expertise, (2) to develop the study protocol and Manual of Procedures (MOP), and (3) to outline and perform preliminary and feasibility studies. The planned study will have multiple innovative elements, the most important being (a) first multicenter observational study with a focus on ROP/AVO, (b) retina imaging at multiple timepoints after birth, (c) artificial intelligence/machine learning approaches, (d) social determinants of health, (e) pre- and postnatal biomarker measurements, and (f) visual and neurodevelopmental outcome assessment.