The role of cognitive load on lateralized motor control processes

认知负荷对偏侧运动控制过程的作用

• 批准号: 10646023
• 负责人: Shanie Amanda Liyanagamage Jayasinghe
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646023
• 关键词: Activities of Daily Living; Address; Affect; Behavior; Brain Injuries; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Data; Dependence; Dissociation; Elbow; Electromyography; Foundations; Goals; Hand functions; Handedness; Impaired cognition; Impairment; Individual; Knowledge; Left; Literature; Measures; Methods; Motion; Motor; Movement; Muscle; Nature; Paresis; Performance; Physical Rehabilitation; Play; Preparation; Process; Reaction Time; Rehabilitation therapy; Research; Role; Short-Term Memory; Shoulder; Side; Standardization; Stroke; Surface; System; Testing; Training; Upper Extremity; Work; arm; arm function; arm movement; arm paresis; chronic stroke; clinically relevant; cognitive load; cognitive neuroscience; cognitive process; design; dexterity; disability; evidence base; experience; experimental study; functional independence; functional outcomes; hemiparesis; hemisphere damage; improved; indexing; kinematics; motor control; motor deficit; motor learning; novel; post stroke; recruit; rehabilitation strategy; remediation; stroke rehabilitation; stroke survivor; virtual reality

Project Summary/Abstract Upper limb physical rehabilitation post stroke tends to focus mainly on remediating deficits related to motor execution of the impaired arm. This approach can be problematic due to two major reasons: (1) efficient movement requires both intact cognition and motor execution, and (2) previous research shows that movement deficits depend on the side of brain damage; importantly, these deficits are present even in the “unimpaired”, ipsilesional arm. While there is a large body of evidence on the lateralization of motor control processes, research on lateralized cognitive processes is limited. Previous studies show that right brain damage produces larger deficits in cognitive processes, such as working memory and action selection, than left brain damage. Our preliminary studies examining hemisphere-specific deficits in motor execution demonstrate that ipsilesional arm movement planning deficits in individuals with left brain damage are highly correlated with functional independence. Surprisingly, this relationship was not found in individuals with right brain damage. Based on our preliminary studies and prior literature, we hypothesize that increased cognitive load produces functionally limiting deficits in the control of movement that differ based on the side of brain damage. We predict that with increased cognitive load, movement deficits will be larger with right than left brain damage. Additionally, we predict that functional independence will be correlated with cognitive deficits in right hemisphere damaged individuals and with motor execution deficits in left hemisphere damaged individuals. We will utilize a novel paradigm that integrates a cognitive challenge with an upper limb reaching task. This method provides a more real-world design for studying how cognitive load affects functional movement compared to dual-task paradigms that involve a cognitively-challenging task in parallel with the motor task. We will recruit 36 chronic stroke survivors with severe hemiparesis for our studies. They will each complete two tasks on a virtual reality motion tracking system, which are designed to assess deficits in ipsilesional arm motor execution and cognitive aspects of movement. We will also use standardized clinical assessments of ipsilesional arm function and functional independence. This proposal assembles an investigative team comprised of experts in cognitive neuroscience and stroke rehabilitation to accomplish the following aims: (1) To determine whether ipsilesional arm deficits in motor control are affected by cognitive load differently in left and right hemisphere damaged stroke survivors with severe contralesional paresis; (2) To determine whether deficits in ipsilesional arm motor execution and cognitive aspects of movement predict functional independence differently between left and right hemisphere damaged stroke survivors with severe contralesional paresis. The results of these studies will be used to develop personalized rehabilitation strategies that account for hemisphere-specific deficits in motor control, and will be particularly useful for severely impaired stroke survivors who depend exclusively on their ipsilesional arm to conduct activities of daily living.

项目总结/摘要 脑卒中后上肢康复治疗主要集中在修复运动功能障碍 这种方法可能是有问题的，由于两个主要原因：（1）效率 运动需要完整的认知和运动执行，（2）先前的研究表明，运动 缺陷取决于脑损伤的一面;重要的是，这些缺陷甚至存在于“未受损”中， 虽然有大量关于运动控制过程的偏侧化的证据， 对侧化认知过程的研究是有限的。先前的研究表明，右脑损伤会产生 更大的认知过程的缺陷，如工作记忆和行动选择，比左脑损伤。 我们的初步研究检查了运动执行的半球特异性缺陷，表明同侧损伤 左脑损伤患者的手臂运动计划缺陷与功能性 独立令人惊讶的是，这种关系在右脑损伤的个体中没有发现。基于 我们的初步研究和先前的文献，我们假设，增加认知负荷产生功能性 限制运动控制方面的缺陷，这些缺陷因脑损伤的一侧而异。我们预测， 认知负荷增加，右脑损伤的运动缺陷会比左脑损伤大。另外我们 预测功能独立性将与右半球受损的认知缺陷相关 个体和运动执行缺陷的左半球受损的个人。我们将利用一本小说 该范例将认知挑战与上肢到达任务相结合。该方法提供了一个更 真实世界的设计，用于研究认知负荷与双任务相比如何影响功能运动 范式涉及认知挑战性任务与运动任务并行。我们将招募36名慢性 严重偏瘫的中风幸存者进行研究他们每个人将在虚拟现实中完成两项任务 运动跟踪系统，旨在评估同侧手臂运动执行和认知能力的缺陷 运动的方面。我们还将使用同侧手臂功能的标准化临床评估， 功能独立。该提案组建了一个由认知科学专家组成的调查小组， 目的：（1）确定脑卒中患者是否存在脑卒中后抑郁症， 认知负荷对左、右半球损伤者上肢运动控制功能的影响不同 脑卒中幸存者严重对侧肢体轻瘫;（2）确定是否存在同侧手臂运动障碍 运动的执行和认知方面预测功能独立性的不同，左，右 大脑半球受损的中风幸存者，伴有严重的对侧病变轻瘫。这些研究的结果将是 用于制定个性化的康复策略，解释大脑半球特定的运动缺陷， 控制，并将特别有用的严重受损中风幸存者谁完全依赖于他们的 同侧臂进行日常生活活动。