Towards elucidating PTSD pathogenesis with ultra-portable and low-cost neuroimaging

通过超便携式和低成本的神经影像学阐明 PTSD 发病机制

• 批准号: 10644627
• 负责人: STEPHANIE BALTERS
• 金额: $ 12.67万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644627
• 关键词: 3-Dimensional; Address; Adult; Affect; American; Amygdaloid structure; Area; Assessment tool; Behavioral; Biological Markers; Brain; Brain imaging; Brain region; Breathing; Career Mobility; Characteristics; Chronic stress; Clinical; Collaborations; Complex; Cross-Sectional Studies; Data Set; Development; Development Plans; Diagnosis; Disease; Doctor of Philosophy; Emotional; Emotions; Engineering; Environment; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Galvanic Skin Response; Gaussian model; Goals; Hippocampus; Hydrocortisone; Imaging technology; Individual; Intervention; Interview; Knowledge; Laboratories; Licensing; Magnetic Resonance Imaging; Measurement; Measures; Methods; Monitor; Neurobiology; Neurosciences; Outcome; Pathogenesis; Pathway interactions; Pattern; Persons; Population; Positioning Attribute; Post-Traumatic Stress Disorders; Precision Health; Prefrontal Cortex; Prognosis; Psychophysiology; Research; Research Personnel; Salivary; Science; Scientist; Secure; Severities; Signal Transduction; Stimulus; Stress; Symptoms; Technology; Testing; Training; Trauma; Treatment outcome; United States National Institutes of Health; Universities; Validation; Woman; Work; accurate diagnosis; acute stress; career; career development; career preparation; cohort; cost; cost effective; emotion regulation; experience; feasibility testing; forging; functional near infrared spectroscopy; heart rate variability; imaging biomarker; imaging modality; improved; innovation; machine learning algorithm; men; multidisciplinary; neuroimaging; novel; optimal treatments; portability; post-doctoral training; precision medicine; research and development; research faculty; response; sensor; skills; success; symptomatic improvement; trait; trauma exposure; treatment planning

PROJECT SUMMARY The long-term career goal of the K99/R00 applicant, Dr. Stephanie Balters, is to continue her career transition from engineering and functional Near-Infrared Spectroscopy (fNIRS) neuroimaging into the clinical neuroscience of Posttraumatic Stress Disorder (PTSD). Specifically, her aim is to develop fNIRS neuroimaging methods that will advance the science of PTSD in addressing questions about brain mechanisms underlying this complex disorder, with the goal of improving diagnosis and treatment of PTSD (i.e., Precision Medicine). Through her Ph.D. and postdoctoral training, Dr. Balters has acquired fundamental knowledge in the psychophysiology and neuroscience of acute and chronic stress; she has advanced the measurement with various psychophysiological sensors from the laboratory into naturalistic environments (e.g., salivary cortisol, heart rate variability, skin conductance); she has built novel unobtrusive stress sensors (e.g., steering wheel stress sensor) and subtle interventions (e.g., Precision Health breathing intervention); has gathered considerable experience in applying fNIRS neuroimaging within naturalistic environments; and has analyzed existing fNIRS-PTSD datasets. However, she has not yet conducted an fNIRS study focused on a clinical PTSD population. To facilitate her career transition to a research faculty position and conduct reliable and safe PTSD neuroimaging research independently (yet in close collaboration with her licensed clinical colleagues), she further requires essential research skills and career preparation. Specifically, Dr. Balters will acquire training in 1) the clinical presentation and diagnosis of PTSD; 2) concurrent fNIRS-fMRI; 3) machine learning algorithms, with focus on Gaussian Models; and 4) skills for independence. Her short-term goal is to acquire the critical didactic and “hands-on” training (1-4) during the K99 period, and to apply these new skills in the R00 period independently. The overarching objective of the proposed K99/R00 research is to develop novel brain imaging methods that enable the assessment of PTSD brain biomarkers in an affordable, portable, and repeated manner. The central hypothesis is that aberrant brain function related to PTSD can be measured with fNIRS. Three specific aims will be addressed: (1) derive cortical biomarkers of PTSD with fNIRS; (2) infer deep brain biomarkers of PTSD with fNIRS; and (3) assess day-to-day fluctuations of fNIRS biomarkers. Successful completion of this K99/R00 research will make significant inroads to providing scientists access to affordable and valid biomarkers of PTSD for diagnosis and improved understanding of brain mechanisms underlying PTSD. Dr. Balters will be equipped with a unique and interdisciplinary skill set to advance PTSD neuroimaging with fNIRS. To bolster her potential for success, Dr. Balters positioned herself within an outstanding research and academic environment at Stanford University, secured the support of exceptional advisors who are committed to catalyzing her NIH pathway to independence, and has developed a strong strategic training plan. Dr. Balters’ completion of the research and career development plan is indispensable to her transition to an independent career in clinical neuroscience.

项目摘要 K99/R 00申请人Stephanie Balters博士的长期职业目标是继续她的职业转型 从工程和功能近红外光谱（fNIRS）神经成像到临床神经科学 创伤后应激障碍（PTSD）。具体来说，她的目标是开发fNIRS神经成像方法， 将推进创伤后应激障碍的科学研究，以解决有关这种复杂性背后的大脑机制的问题。 疾病，目的是改善PTSD的诊断和治疗（即，精准医学）。通过她 博士和博士后培训，巴特斯博士已经获得了心理生理学的基础知识， 神经科学的急性和慢性压力;她已经先进的测量与各种心理生理 传感器从实验室进入自然环境（例如，唾液皮质醇，心率变异性，皮肤 电导）;她已经构建了新颖的不显眼的应力传感器（例如，方向盘应力传感器）和微妙的 干预（例如，精准健康呼吸干预）;在应用方面积累了相当丰富的经验 自然环境中的fNIRS神经成像;并分析了现有的fNIRS-PTSD数据集。 然而，她还没有进行一项针对临床PTSD人群的fNIRS研究。便利她 职业生涯过渡到研究教师的位置，并进行可靠和安全的创伤后应激障碍神经影像学研究 独立地（但与她的持牌临床同事密切合作），她进一步要求基本的 研究技能和职业准备。具体来说，巴特斯博士将获得1）临床表现方面的培训 PTSD的诊断; 2）并发fNIRS-fMRI; 3）机器学习算法，重点是高斯 （4）独立能力。她的短期目标是获得关键的说教和“动手” 培训（1-4）在K99期间，并在R 00期间独立应用这些新技能。的 K99/R 00研究的首要目标是开发新的脑成像方法， 以负担得起的、便携的和可重复的方式评估PTSD脑生物标志物。中央 假设与PTSD相关的异常脑功能可以用fNIRS测量。三个具体目标将 解决：（1）用fNIRS推导PTSD的皮质生物标志物;（2）用fNIRS推断PTSD的深部脑生物标志物。 fNIRS;和（3）评估fNIRS生物标志物的每日波动。成功完成此K99/R 00 研究将取得重大进展，为科学家提供负担得起的有效的PTSD生物标志物 用于诊断和提高对创伤后应激障碍潜在大脑机制的理解。巴特斯博士将配备 具有独特的跨学科技能，可通过fNIRS推进PTSD神经成像。为了增强她的潜力 为了取得成功，巴特斯博士将自己定位在斯坦福大学一个杰出的研究和学术环境中 大学，获得了特殊顾问的支持，他们致力于催化她的NIH途径， 独立性，并制定了强有力的战略培训计划。巴特斯博士完成了研究， 职业发展计划是她过渡到临床神经科学独立职业不可或缺的。