Effects of per- and polyfluoroalkyl substances on placental features and size at birth

全氟烷基和多氟烷基物质对出生时胎盘特征和大小的影响

• 批准号: 10645524
• 负责人: Megan E Romano
• 金额: $ 8.17万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-23 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645524
• 关键词: Acetates; Adult; Affect; Air; Alkanesulfonates; Area; Biological; Biopsy; Birth; Birth Weight; Birth length; Blood; Chemicals; Child; Circulation; Clinical; Cohort Studies; Data; Deterioration; Diameter; Diet; Enrollment; Environment; Environmental Pollutants; Epidemiology; Exposure to; Family; Fetal Development; Fetal health; Food; Food Supply; General Population; Gestational Diabetes; Goals; Growth; Guidelines; Head circumference; Health; Health Policy; Human; Industrialization; Industry; Infant; Ingestion; Kidney; Knowledge; Literature; Liver; Low Birth Weight Infant; Maternal Health; Maternal and Child Health; Measures; Mediating; Metabolic; Metadata; Methodology; Modeling; Monitor; Morbidity - disease rate; Mothers; New Hampshire; Newborn Infant; Nutrient; Outcome; Oxygen; Personal Satisfaction; Placenta; Placental Insufficiency; Placentation; Play; Policies; Poly-fluoroalkyl substances; Population; Pre-Eclampsia; Predisposition; Pregnancy; Pregnant Women; Production; Prospective cohort; Regulation; Research; Risk; Role; Rural; Sample Size; Sentinel; Source; Specimen; Subgroup; Testing; Time; Tissues; Toxicant exposure; Water; Water Pollutants; Water Supply; Weight; Woman; Work; adverse birth outcomes; cardiovascular risk factor; clinical practice; cohort; consumer product; drinking water; epidemiology study; excessive fetal growth; gestational weight gain; improved; indexing; infant morbidity; infant morbidity/mortality; maternal outcome; novel; perfluorohexane; perfluorooctane; perfluorooctane sulfonate; perfluorooctanoic acid; pollutant; pregnancy hypertension; prenatal; prenatal exposure; prevent; prospective; public health priorities; sex; sociodemographics; time-to-pregnancy; toxicant; wasting

PROJECT SUMMARY Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and highly persistent chemicals, that have been used widely in industry for seven decades and are known to adversely influence maternal and child health. PFAS have recently become a public health priority evidenced by President Biden’s call to action to prevent the adverse impacts from PFAS present in our air, water, and food supply. Achieving this goal necessitates monitoring a broad range of PFAS and determining the health effects of realistic scenarios of exposures to PFAS mixtures, though most prior research has investigated PFAS one at a time. Moreover, data are needed to inform national policies, and clinical guidelines can only be determined by studying the most susceptible populations, namely pregnant women and newborns. Therefore, to inform national policies and clinical guidelines, we propose to investigate the risks associated with prenatal exposure to PFAS in the New Hampshire Birth Cohort Study, a large rural U.S. cohort of over 2,400 mother-infant dyads with anticipated enrollment of 3,000. We will investigate the effects of PFAS, measured in maternal blood during pregnancy, on placental features and birth size, which is a sentinel outcome, with both insufficient and excessive fetal growth contributing to infant morbidity and mortality and enduring risk of cardiovascular and metabolic morbidity well into adulthood. We will leverage extensive extant data from our decade-long cohort, including toxicant exposure and clinical metadata. We will test the hypothesis that PFAS, alone and as mixtures, adversely affect placental features and reduce size at birth. Further, we will explore whether associations of PFAS with size at birth are mediated by the influence of PFAS on the placenta. Our work will integrate advances in statistical methodologies for evaluating exposure mixtures and evaluate PFAS for which effective federal regulations do not yet exist.

项目摘要 全氟烷基和多氟烷基物质（PFAS）是普遍存在的高持久性化学品， 在工业中广泛使用了七十年，已知对孕产妇和儿童健康产生不利影响。 PFAS最近已成为公共卫生的优先事项，拜登总统呼吁采取行动， PFAS对我们的空气、水和食物供应的不利影响。实现这一目标需要 监测广泛的PFAS，并确定现实的接触情景对健康的影响， PFAS混合物，尽管大多数先前的研究一次只研究一种PFAS。此外，还需要数据 为国家政策提供信息，临床指南只能通过研究最易感的 人口，即孕妇和新生儿。因此，为了告知国家政策和临床 指南，我们建议调查与产前暴露于PFAS在新的 汉普郡出生队列研究，一项由2,400多对母婴组成的美国农村队列研究， 报名人数3000人。我们将研究妊娠期母体血液中PFAS的影响， 胎盘特征和出生大小，这是一个前哨结果，胎儿生长不足和过度 导致婴儿发病率和死亡率以及心血管和代谢发病率的持久风险 长大成人我们将利用我们长达十年的队列中广泛的现有数据，包括有毒物质， 暴露和临床元数据。我们将检验PFAS单独和作为混合物对 胎盘特征和出生时缩小尺寸。此外，我们将探讨PFAS与大小的关系， 分娩是由PFAS对胎盘的影响介导的。我们的工作将结合统计方面的进展， 评估暴露混合物的方法，并评估有效的联邦法规 还不存在