Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial

瑜伽、有氧运动和伸展运动对神经认知能力的影响：一项随机对照试验

• 批准号: 10645168
• 负责人: Neha Pravin Gothe
• 金额: $ 5.75万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10645168
• 关键词: Activities of Daily Living; Adult; Aerobic; Aerobic Exercise; Affect; Age; Age Years; Age-associated memory impairment; Aging; Alternative Therapies; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; Anxiety; Area; Attention; Behavioral; Biological Markers; Blood; Brain; Brain imaging; Brain-Derived Neurotrophic Factor; Breathing; Chronic; Cognition; Cognitive; Collaborations; Complementary Health; Complementary Medicine; Control Groups; Creativeness; Effectiveness; Elderly; Exercise; Exhibits; Functional Magnetic Resonance Imaging; Future; Health; Health Care Costs; Hippocampus; Hour; Hydrocortisone; Impaired cognition; Individual; Interleukin-6; Intervention; Investigation; Link; Low Back Pain; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Memory; Mental Depression; Mind-Body Intervention; Modality; Nature; Neurobiology; Neurocognitive; Neurons; Neuropsychology; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Older Population; Outcome; Participant; Performance; Personal Satisfaction; Persons; Physical activity; Physiological; Population; Prefrontal Cortex; Prevalence; Preventive; Productivity; Public Health; Randomized; Randomized, Controlled Trials; Recording of previous events; Research; Research Personnel; Role; Serum; Single-Blind Study; Speed; Stress; Stretching; Structure; Testing; Therapeutic; Time; Training; Walking; Yoga; active control group; age related; arm; behavior measurement; brain health; cardiorespiratory fitness; cardiovascular fitness; cognitive benefits; cognitive function; cognitive performance; comorbidity; comparative efficacy; cost effective; effectiveness evaluation; executive function; exercise intervention; exercise program; exercise training; experience; fitness; fitness test; follow-up; group intervention; improved; indexing; inflammatory marker; interest; middle age; mind/body; molecular marker; neurocognitive test; neuropathology; pilot trial; prevent; psychologic; public health relevance; remediation; skills

Abstract Yoga, a physical activity based mind-body therapy has become increasingly popular as a preventive and therapeutic practice, making it one of the therapies with the most rapid increase in prevalence. Practice of yoga combines physical activity, modulated breathing and meditative exercises that combine to provide the practitioner a holistic mind-body experience. The effectiveness of yoga has been examined for a number of health outcomes, including stress, anxiety, depression, management of chronic conditions such as lower back pain and type 2 diabetes. Fewer studies have examined the effects of yoga practice on brain health and cognitive function. Age related cognitive decline is well documented. With the increasing population of older adults in the US, there is a need to not only test popular forms of exercise such as yoga, but also compare their efficacy with modalities such as aerobic exercise that have proven neurocognitive benefits. This research is timely in that yoga is a gentle and modifiable form of exercise that can be easily adapted for practice by older adults who may exhibit comorbidities or chronic health conditions that keep them from walking or performing other forms of aerobic exercise. To our knowledge, this is the first randomized control trial examining and comparing the effects of yoga and aerobic exercise training on behavioral and neurobiological correlates of cognitive function. We propose to conduct a 6-month randomized controlled exercise trial among older adults to compare the efficacy of yoga with aerobic exercise on cognitive function, brain structure and function, cardiorespiratory fitness, functional fitness, and inflammatory and molecular markers. Using a single-blind, three arm randomized control trail, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or an active stretching and strengthening control group. The groups will engage in hour-long group exercise sessions 3x/week. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. The proposed pilot RCT will examine the relationship between yoga training and improved cognitive functioning as well as identify neurobiological correlates as potential mechanisms of action through which yoga training exerts its effect on cognitive function. The investigative team is interdisciplinary, highly productive and has a history of collaboration in conducting exercise interventions examining neurocognitive outcomes in older adults.

抽象的 瑜伽是一种基于体育活动的思维疗法，作为一种预防性和 治疗实践，使其成为患病率最快的疗法之一。瑜伽的实践 结合体育锻炼，调节呼吸和冥想练习，共同提供 从业者是整体思维体验。已经检查了许多瑜伽的有效性 健康结果，包括压力，焦虑，抑郁，慢性疾病的管理，例如下背部 疼痛和2型糖尿病。较少的研究检查了瑜伽实践对大脑健康的影响 认知功能。与年龄相关的认知下降有充分的记录。随着年龄较大的人口的增加 在美国的成年人，不仅需要测试流行的运动形式，例如瑜伽，而且还需要比较 它们对有氧运动诸如神​​经认知益处之类的有氧运动等方式的功效。这项研究 及时，瑜伽是一种柔和且可修改的运动形式，可以很容易地适应练习 可能表现出合并症或慢性健康状况的成年人，以防止他们走路或表演 其他形式的有氧运动。据我们所知，这是第一个随机对照试验检查 并比较瑜伽和有氧运动训练对行为和神经生物学的影响 认知功能的相关性。 我们建议对老年人进行6个月的随机对照运动试验，以比较 有氧运动对认知功能，大脑结构和功能，心肺的功效 适应性，功能适应性以及炎症和分子标记。使用单双臂 随机控制径，168名55-79岁的老年人将分配给：Hatha瑜伽组，一个 有氧运动组或主动拉伸和加强对照组。小组将参与 长达一个小时的小组练习会议3倍/周。全面的神经认知测试电池，大脑成像， 心血管健身测试，并在基线时进行抽血；六个月的干预结束，在 12个月的随访。 拟议的飞行员RCT将检查瑜伽训练与改善认知之间的关系 功能以及识别神经生物学的相关性作为动作的潜在机制 哪种瑜伽训练对认知功能产生了影响。 调查团队是跨学科的，高产性，并且有合作的历史 运动干预措施检查老年人的神经认知结果。