Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial

瑜伽、有氧运动和伸展运动对神经认知能力的影响：一项随机对照试验

• 批准号: 10645168
• 负责人: Neha Pravin Gothe
• 金额: $ 5.75万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2023-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10645168
• 关键词: Activities of Daily Living; Adult; Aerobic; Aerobic Exercise; Affect; Age; Age Years; Age-associated memory impairment; Aging; Alternative Therapies; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease risk; Anxiety; Area; Attention; Behavioral; Biological Markers; Blood; Brain; Brain imaging; Brain-Derived Neurotrophic Factor; Breathing; Chronic; Cognition; Cognitive; Collaborations; Complementary Health; Complementary Medicine; Control Groups; Creativeness; Effectiveness; Elderly; Exercise; Exhibits; Functional Magnetic Resonance Imaging; Future; Health; Health Care Costs; Hippocampus; Hour; Hydrocortisone; Impaired cognition; Individual; Interleukin-6; Intervention; Investigation; Link; Low Back Pain; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Memory; Mental Depression; Mind-Body Intervention; Modality; Nature; Neurobiology; Neurocognitive; Neurons; Neuropsychology; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Older Population; Outcome; Participant; Performance; Personal Satisfaction; Persons; Physical activity; Physiological; Population; Prefrontal Cortex; Prevalence; Preventive; Productivity; Public Health; Randomized; Randomized, Controlled Trials; Recording of previous events; Research; Research Personnel; Role; Serum; Single-Blind Study; Speed; Stress; Stretching; Structure; Testing; Therapeutic; Time; Training; Walking; Yoga; active control group; age related; arm; behavior measurement; brain health; cardiorespiratory fitness; cardiovascular fitness; cognitive benefits; cognitive function; cognitive performance; comorbidity; comparative efficacy; cost effective; effectiveness evaluation; executive function; exercise intervention; exercise program; exercise training; experience; fitness; fitness test; follow-up; group intervention; improved; indexing; inflammatory marker; interest; middle age; mind/body; molecular marker; neurocognitive test; neuropathology; pilot trial; prevent; psychologic; public health relevance; remediation; skills

Abstract Yoga, a physical activity based mind-body therapy has become increasingly popular as a preventive and therapeutic practice, making it one of the therapies with the most rapid increase in prevalence. Practice of yoga combines physical activity, modulated breathing and meditative exercises that combine to provide the practitioner a holistic mind-body experience. The effectiveness of yoga has been examined for a number of health outcomes, including stress, anxiety, depression, management of chronic conditions such as lower back pain and type 2 diabetes. Fewer studies have examined the effects of yoga practice on brain health and cognitive function. Age related cognitive decline is well documented. With the increasing population of older adults in the US, there is a need to not only test popular forms of exercise such as yoga, but also compare their efficacy with modalities such as aerobic exercise that have proven neurocognitive benefits. This research is timely in that yoga is a gentle and modifiable form of exercise that can be easily adapted for practice by older adults who may exhibit comorbidities or chronic health conditions that keep them from walking or performing other forms of aerobic exercise. To our knowledge, this is the first randomized control trial examining and comparing the effects of yoga and aerobic exercise training on behavioral and neurobiological correlates of cognitive function. We propose to conduct a 6-month randomized controlled exercise trial among older adults to compare the efficacy of yoga with aerobic exercise on cognitive function, brain structure and function, cardiorespiratory fitness, functional fitness, and inflammatory and molecular markers. Using a single-blind, three arm randomized control trail, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or an active stretching and strengthening control group. The groups will engage in hour-long group exercise sessions 3x/week. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. The proposed pilot RCT will examine the relationship between yoga training and improved cognitive functioning as well as identify neurobiological correlates as potential mechanisms of action through which yoga training exerts its effect on cognitive function. The investigative team is interdisciplinary, highly productive and has a history of collaboration in conducting exercise interventions examining neurocognitive outcomes in older adults.

摘要 瑜伽，一种以身体活动为基础的身心疗法，作为一种预防和治疗疾病的方法， 治疗实践，使其成为流行率增长最快的疗法之一。练习瑜伽 结合了身体活动，调节呼吸和冥想练习，这些练习结合了联合收割机， 实践者的整体身心体验。瑜伽的有效性已经过多次检验， 健康结果，包括压力，焦虑，抑郁，慢性疾病的管理，如下背部 疼痛和2型糖尿病。很少有研究调查瑜伽练习对大脑健康的影响， 认知功能与年龄相关的认知能力下降是有据可查的。随着老年人口的增加， 在美国的成年人中，不仅需要测试瑜伽等流行的运动形式，而且还需要比较 他们的疗效与模式，如有氧运动，已被证明的神经认知的好处。本研究 是及时的，因为瑜伽是一种温和的，可改变的运动形式，可以很容易地适应老年人的练习 可能表现出使他们无法行走或表演的合并症或慢性健康状况的成年人 其他形式的有氧运动据我们所知，这是第一个随机对照试验， 比较瑜伽和有氧运动训练对行为和神经生物学的影响 认知功能的相关因素。 我们建议在老年人中进行一项为期6个月的随机对照运动试验， 瑜伽有氧运动对认知功能、脑结构和功能、心肺功能影响 适应性、功能适应性以及炎症和分子标记物。使用单盲、三臂 随机对照试验，168名年龄在55-79岁的老年人将被分配到以下两组中的一组：哈达瑜伽组， 有氧运动组或主动拉伸强化对照组。这些团体将参与 一小时的小组锻炼课程，每周3次。全面的神经认知测试，脑成像， 心血管健康测试和抽血将在基线时进行; 6个月干预结束时， 12-月随访。 拟议的试点RCT将研究瑜伽训练和改善认知能力之间的关系。 功能以及识别神经生物学相关的潜在作用机制， 瑜伽训练对认知功能的影响。 调查小组是跨学科的，富有成效，并有合作的历史， 运动干预检查老年人的神经认知结果。