Clinical Pediatric Research Training for the Fetal-Neonatal Brain

摘要/摘要 这项申请的基本原理是为了填补目前新兴学科临床研究培训的空白。 胎儿-新生儿神经病学。胎儿和新生儿大脑的快速发展，以及独特的遗传和 威胁这种发育的环境因素，使未成熟的大脑明显不同于 甚至是年龄较大的婴儿。然而，尽管人们越来越认识到在这一关键时期发生的事件的寿命影响 在此期间，在胎儿和新生儿神经学方面的临床和研究培训仍然明显不足。 该计划的目标是在临床神经科学研究方面提供多学科培训 胎儿/新生儿环境的背景。实习生将进入一个两到三年的计划，拥有医学博士学位，DO， 博士或医学博士/博士学位。胎儿脑临床研究培训计划的首发地 是位于华盛顿特区的儿童国家卫生系统(CNHS)。培训将在 负责任地进行研究，在NICU获取高通量的临床数据，以及 使用复杂的神经诊断技术处理和分析数据。美国国立卫生研究院资助的两个校长 具有互补临床和研究专业知识的研究人员将得到神经科学的支持 来自新生儿的导师(神经学、神经放射学、神经遗传学)和导师/主题专家 重症监护、新生儿心脏手术和临床研究方法。导师团队是 由儿童国立大学和乔治华盛顿大学(GWU)组成。少年儿童国家队很好 基于(I)其在翻译和临床研究以及指导方面的优势，定位为领导该计划 在中心研究领域；(2)与Inova的正式资助的研究协作(CNICA方案) 妇女和儿童医院，以及(Iii)其胎儿和新生儿医学计划的优势。每个人 学员将在高级神经诊断技术方面发展特殊专业知识，完成 GWU或同等学力的健康科学临床科学(MSHS)，并将设计和实施 由她/他的指导团队监督的研究项目。到毕业时，实习生将展示他/她的 向至少一次国家研究会议提交数据，向外部同行评审提交一篇或多篇稿件 期刊，并有一个精心制定的拨款申请计划。该计划将为受训人员提供 在努力减少和预防胎儿脑损伤方面发展成为未来领导者的技能和专业知识 和新生婴儿。

SUMMARY/ABSTRACT The rationale for this application is to fill the current void in clinical research training for the emerging discipline of fetal-neonatal neurology. The rapid development of the fetal and newborn brain, and the unique genetic and environmental factors that threaten such development, make the immature brain distinctly different from that of even older infants. Yet, despite the growing recognition of the lifespan impact of events during this critical period, clinical and research training in neurology of the fetus and newborn remains remarkably inadequate. The objective of this program is to provide multidisciplinary training in clinical neuroscience research within the context of the fetal/neonatal environment. Trainees will enter a two to three year program with an MD, DO, PhD or MD/PhD. The primary site for the Clinical Research Training Program for the Fetal Neonatal Brain is the Children’s National Health System (CNHS) in Washington, D.C. Training will be provided in the responsible conduct of research, the acquisition of high-throughput ‘bedside’ clinical data in the NICU, and the processing and analysis of data using sophisticated neurodiagnostic techniques. Two NIH-funded Principal Investigators with complementary clinical and research expertise will be supported by neuroscience preceptors (neurology, neuroradiology, neurogenetics), and mentors/subject matter experts from neonatal intensive care, neonatal cardiac surgery, and clinical research methodology. The mentorship team is assembled from Children’s National and the George Washington University (GWU). Children’s National is well positioned to lead this program, based on (i) its strengths in translational and clinical research, and mentorship in the central areas of inquiry; (ii) its formal funded research collaboration (CNICA Program) with Inova Women’s and Children’s Hospitals, and (iii) the strength of its fetal and neonatal medicine programs. Each trainee will develop special expertise in an advanced neurodiagnostic technique, complete a Master’s of Science in Health Sciences Clinical (MSHS) at GWU or equivalent, and will design and implement a research project overseen by her/his mentorship team. By graduation, the trainee will have presented his/her data to at least one national research meeting, submitted one or more manuscripts to external peer-reviewed journals, and have a well-formulated plan for a grant application. The program will prepare trainees with the skills and expertise to develop into future leaders in the effort to reduce and prevent brain injury in the fetus and newborn infant.