The Role of ICU Delirium and Vascular Risk Factors in the Development of Post-ICU Cognitive Impairment and Dementia

项目摘要 这份建议书描述了一个职业发展计划，将王医生转变为一名病人- 一位专注于建立新的干预措施以预防或延迟阿尔茨海默氏症的研究人员 疾病和其他相关痴呆（ADRD）的谵妄幸存者。王博士提出的项目 将涉及筛选药理学研究受试者的次要数据分析 谵妄管理（PMD）研究，一项已完成的R01临床试验， 氟哌啶醇治疗重症监护室（ICU）谵妄，合并电子病历 数据来自印第安纳州患者护理网络数据库。本项目将研究 ICU谵妄、ICU前心血管危险因素和ICU后抑郁的发生 重症监护室后认知障碍和副反应性障碍该项目的完成将建立博士。 Wang的职业生涯是以患者为导向的研究者，以确定ICU后认知障碍的风险因素。 并在ICU谵妄幸存者中制定有针对性的干预措施。 这一拟议的职业发展计划整合了1）课程和结构化教学法， 生物统计学，流行病学和临床试验方法，导致硕士学位， 临床研究，2）领导技能和跨学科合作，为她准备一个 职业生涯作为一个以病人为导向的研究者，3）参加国家会议，以制定 老年谵妄幸存者和ADRD的专业知识，4）多学科导师小组， 良好的记录，不断增长的初级研究人员，和5）理想的研究环境， 研究谵妄和ADRD的交叉领域。该环境包括一个 国际公认的NIH资助的PMD研究小组，著名的印第安纳州大学 老龄化研究中心、美国国立卫生研究院资助的印第安纳州阿尔茨海默病中心和美国国立卫生研究院- 资助的印第安纳州临床和转化科学研究所（CTSI）。这种职业发展 奖励将保证保护的时间，这将是必要的，以促进候选人的职业生涯， 老年重症监护室谵妄幸存者和ADRD。此外，该奖项将提供关键支持， 为未来的R01临床试验收集数据，以测试预防和延迟ICU后的干预措施 谵妄幸存者的认知障碍和ADRD。

PROJECT SUMMARY This proposal describes a career development plan that will transform Dr. Wang into a patient- oriented investigator focused on building novel interventions to prevent or delay Alzheimer's disease and other related dementias (ADRD) in delirium survivors. Dr. Wang's proposed project will involve the secondary data analysis of research subjects screened for the Pharmacologic Management of Delirium (PMD) study, a completed R01 clinical trial testing the efficacy of haloperidol to treat intensive care unit (ICU) delirium, merged with electronic medical record data from the Indiana Network for Patient Care Database. This project will examine the role of ICU delirium, pre-ICU cardiovascular risk factors, and post-ICU depression in the development of post-ICU cognitive impairment and ADRD. The completion of this project will establish Dr. Wang's career as a patient oriented investigator to identify risk factors for post-ICU cognitive impairment and ADRD and develop targeted interventions in ICU delirium survivors. This proposed career development plan integrates 1) coursework and structured didactics in biostatistics, epidemiology, and clinical trials methodology that lead up to a master's degree in clinical research, 2) leadership skills and interdisciplinary collaboration to prepare her for a career as a patient-oriented investigator, 3) participation in national meetings to develop expertise in older delirium survivors and ADRD, 4) a multidisciplinary mentorship panel with a strong track record of growing junior investigators, and 5) an ideal research environment to study the intersection of the fields of delirium and ADRD. This environment includes an internationally recognized NIH-funded PMD Study Group, the distinguished Indiana University Center for Aging Research, the NIA-funded Indiana Alzheimer's Disease Center, and the NIH- funded Indiana Clinical and Translational Sciences Institute (CTSI). This career development award will guarantee protected time that will be necessary to advance the candidate's career in older ICU delirium survivors and ADRD. In addition, the award will provide critical support to collect data for future R01 clinical trial to test an intervention to prevent and delay post-ICU cognitive impairment and ADRD in delirium survivors.