The Role of ICU Delirium and Vascular Risk Factors in the Development of Post-ICU Cognitive Impairment and Dementia

项目总结 这份提案描述了一项职业发展计划，将王医生转变为患者- 定向调查者专注于建立新的干预措施来预防或延缓阿尔茨海默氏症 精神错乱幸存者的疾病和其他相关痴呆(ADRD)。王博士提出的项目 将涉及对药理学筛选的研究对象的二级数据分析 Delirium(PMD)研究，一项完成的R01临床试验，测试 氟哌啶醇治疗重症监护病房(ICU)精神错乱，与电子病历合并 数据来自印第安纳州患者护理数据库。本项目将考察 ICU神志不清、ICU前心血管危险因素与ICU后抑郁的关系 ICU后认知功能障碍和ADRD。该项目的完成将确立Dr。 王的职业生涯是一名以患者为中心的调查员，以确定ICU后认知的危险因素 损害和ADRD，并对ICU精神错乱幸存者进行有针对性的干预。 这项拟议的职业发展计划将1)课程作业和结构化教学结合在一起 生物统计学、流行病学和临床试验方法论 临床研究，2)领导技能和跨学科合作，为她的 作为一名以患者为中心的调查员，3)参与国家会议以发展 老年精神错乱幸存者和ADRD方面的专业知识，4)多学科指导小组，有 良好的初级研究人员成长记录，以及5)理想的研究环境 研究精神错乱和ADRD这两个领域的交叉。此环境包括 国际公认的NIH资助的PMD研究小组，著名的印第安纳大学 老龄化研究中心，NIA资助的印第安纳州阿尔茨海默氏症中心，以及NIH- 资助印第安纳州临床和转化科学研究所(CTSI)。这份职业发展 奖励将保证候选人在以下领域取得职业发展所需的受保护时间 老年ICU精神错乱幸存者和ADRD。此外，该奖项将为以下方面提供关键支持 为未来的R01临床试验收集数据，以测试预防和延迟ICU后的干预措施 妄想症幸存者的认知功能障碍和ADRD。

PROJECT SUMMARY This proposal describes a career development plan that will transform Dr. Wang into a patient- oriented investigator focused on building novel interventions to prevent or delay Alzheimer's disease and other related dementias (ADRD) in delirium survivors. Dr. Wang's proposed project will involve the secondary data analysis of research subjects screened for the Pharmacologic Management of Delirium (PMD) study, a completed R01 clinical trial testing the efficacy of haloperidol to treat intensive care unit (ICU) delirium, merged with electronic medical record data from the Indiana Network for Patient Care Database. This project will examine the role of ICU delirium, pre-ICU cardiovascular risk factors, and post-ICU depression in the development of post-ICU cognitive impairment and ADRD. The completion of this project will establish Dr. Wang's career as a patient oriented investigator to identify risk factors for post-ICU cognitive impairment and ADRD and develop targeted interventions in ICU delirium survivors. This proposed career development plan integrates 1) coursework and structured didactics in biostatistics, epidemiology, and clinical trials methodology that lead up to a master's degree in clinical research, 2) leadership skills and interdisciplinary collaboration to prepare her for a career as a patient-oriented investigator, 3) participation in national meetings to develop expertise in older delirium survivors and ADRD, 4) a multidisciplinary mentorship panel with a strong track record of growing junior investigators, and 5) an ideal research environment to study the intersection of the fields of delirium and ADRD. This environment includes an internationally recognized NIH-funded PMD Study Group, the distinguished Indiana University Center for Aging Research, the NIA-funded Indiana Alzheimer's Disease Center, and the NIH- funded Indiana Clinical and Translational Sciences Institute (CTSI). This career development award will guarantee protected time that will be necessary to advance the candidate's career in older ICU delirium survivors and ADRD. In addition, the award will provide critical support to collect data for future R01 clinical trial to test an intervention to prevent and delay post-ICU cognitive impairment and ADRD in delirium survivors.