Aptamer-functionalized cardiac patches

适体功能化心脏贴片

基本信息

批准号：
10645064
负责人：
Yong Wang
金额：
$ 48.6万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10645064
关键词：
Affect Affinity American Angiogenic Factor Apoptosis Binding Biocompatible Materials Blood Circulation Blood Vessels Cardiac Cells Cessation of life Data Development Dose Evaluation Growth Heart Homeostasis Hydrogels Immune Implant In Situ In Vitro Infarction Inflammation Inflammatory Interleukin-2 Kinetics Maintenance Measures Mechanics Myocardial Myocardial Infarction Myocardial Ischemia Myocardium Nucleic Acids Patients Proliferating Recovery Regenerative Medicine Regulatory T-Lymphocyte Signaling Molecule Specificity Structure Testing Therapeutic Agents Thick Thinness Tissues Ventricular angiogenesis aptamer cardiac implant cardiac repair controlled release coronary fibrosis cytokine implantation in vivo mechanical properties new growth novel prevent success therapeutic angiogenesis therapeutic evaluation therapeutic protein

项目摘要

PROJECT SUMMARY Ischemic heart disease affects ~15 million Americans and accounts for ~2,150 deaths every day. The ability to develop multifunctional implants for local delivery of therapeutic agents holds great potential for the treatment of myocardial infarction (MI), which remains challenging today. The objective of this project is to develop a novel cardiac patch with two primary functions of promoting both angiogenesis and anti-inflammation. Compelling preliminary results have been collected, showing that nucleic acid aptamers can be incorporated into hydrogels with the capability of sequestering and releasing therapeutic agents. Based on the compelling results, this project is developed with three specific aims including 1) development of aptamer-functionalized cardiac patches for controlled release of angiogenic factors, 2) evaluation of the functionality of the patches in the promotion of therapeutic angiogenesis and MI treatment, and 3) evaluation of therapeutic angiogenesis and anti-inflammation for synergistic MI treatment. It is anticipated that aptamer-functionalized patches would stably sequester therapeutic proteins and release them in a sustained manner; and that co-delivery of multiple signaling molecules would lead to synergistic MI treatment. The success of this project holds great potential to open a new avenue of developing cardiac implants for the treatment of patients with ischemic heart disease.

项目摘要缺血性心脏病会影响约1500万美国人，每天造成约2,150人死亡。能力开发多功能植入物以局部交付治疗剂具有巨大的治疗潜力今天仍然具有挑战性的心肌梗塞（MI）。该项目的目的是开发小说心脏斑块具有促进血管生成和抗炎的两个主要功能。引人注目已经收集了初步结果，表明核酸适体可以掺入水凝胶中具有隔离和释放治疗剂的能力。基于令人信服的结果，这个项目开发具有三个特定目标，包括1）开发适体功能化的心脏斑块血管生成因子的受控释放，2）评估在促进斑块的功能治疗性血管生成和MI治疗，以及3）评估治疗性血管生成和抗炎用于协同MI处理。预计适体功能化的斑块将稳定隔离治疗蛋白质并以持续的方式释放；以及多个信号分子的共同传递将导致协同的MI治疗。该项目的成功具有开放新途径的巨大潜力用于治疗缺血性心脏病患者的心脏植入物的发展。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Displacement and hybridization reactions in aptamer-functionalized hydrogels for biomimetic protein release and signal transduction.

DOI：
10.1039/c7sc03023a
发表时间：
2017-11-01
期刊：
Chemical science
影响因子：
8.4
作者：
Lai J;Li S;Shi X;Coyne J;Zhao N;Dong F;Mao Y;Wang Y
通讯作者：
Wang Y

Programmable hydrogels.

DOI：
10.1016/j.biomaterials.2018.03.008
发表时间：
2018-09
期刊：
Biomaterials
影响因子：
14
作者：
Wang Y
通讯作者：
Wang Y

Dual Aptamer-Functionalized in Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Codelivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB.

DOI：
10.1021/acsami.9b02462
发表时间：
2019-04
期刊：
ACS applied materials & interfaces
影响因子：
9.5
作者：
Nan Zhao;Akiho Suzuki;Xiaolong Zhang;Peng Shi;Lidya Abune;James Coyne;Huizhen Jia;Na Xiong;Ge Zhang;Yong Wang
通讯作者：
Nan Zhao;Akiho Suzuki;Xiaolong Zhang;Peng Shi;Lidya Abune;James Coyne;Huizhen Jia;Na Xiong;Ge Zhang;Yong Wang

Polymer Microneedle Mediated Local Aptamer Delivery for Blocking the Function of Vascular Endothelial Growth Factor.