Aptamer-functionalized cardiac patches

项目总结 缺血性心脏病影响着约1500万美国人，每天约有2150人死亡。一种能力 开发多功能局部给药植入物具有很大的治疗潜力 心肌梗死(MI)，这在今天仍然具有挑战性。这个项目的目标是开发一种新的 心脏补片具有促进血管生成和抗炎两大主要功能。引人入胜 已经收集的初步结果表明，核酸适配子可以被结合到水凝胶中。 具有隔离和释放治疗剂的能力。基于令人信服的结果，该项目 它的开发有三个特定的目标，包括1)开发适体功能化的心脏补片 血管生成因子的控制释放，2)评价贴剂在促进血管生成方面的功能 治疗性血管生成和心梗治疗，以及3)治疗性血管生成和抗炎的评价 用于协同治疗心肌梗死。预计适体功能化的补丁将稳定地隔离 治疗蛋白并以持续方式释放它们；以及多个信号分子共同传递 将导致心肌梗死的协同治疗。这一项目的成功具有开辟一条新道路的巨大潜力 开发用于治疗缺血性心脏病患者的心脏植入物。

PROJECT SUMMARY Ischemic heart disease affects ~15 million Americans and accounts for ~2,150 deaths every day. The ability to develop multifunctional implants for local delivery of therapeutic agents holds great potential for the treatment of myocardial infarction (MI), which remains challenging today. The objective of this project is to develop a novel cardiac patch with two primary functions of promoting both angiogenesis and anti-inflammation. Compelling preliminary results have been collected, showing that nucleic acid aptamers can be incorporated into hydrogels with the capability of sequestering and releasing therapeutic agents. Based on the compelling results, this project is developed with three specific aims including 1) development of aptamer-functionalized cardiac patches for controlled release of angiogenic factors, 2) evaluation of the functionality of the patches in the promotion of therapeutic angiogenesis and MI treatment, and 3) evaluation of therapeutic angiogenesis and anti-inflammation for synergistic MI treatment. It is anticipated that aptamer-functionalized patches would stably sequester therapeutic proteins and release them in a sustained manner; and that co-delivery of multiple signaling molecules would lead to synergistic MI treatment. The success of this project holds great potential to open a new avenue of developing cardiac implants for the treatment of patients with ischemic heart disease.