CH/BIDMC/Harvard Medical School Neurology Resident Research Education Program

CH/BIDMC/哈佛大学医学院神经病学住院医师研究教育计划

• 批准号: 10645178
• 负责人: Annapurna Poduri
• 金额: $ 8.48万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645178
• 关键词: Address; Adult; Anesthesia procedures; Area; Award; Basic Science; Boston; Brain; Cellular biology; Clinical; Clinical Research; Data; Department chair; Development; Diagnosis; Disease; Education Projects; Educational process of instructing; Environment; Faculty; Faculty Recruitment; Fellowship; Funding; Future; Genetic; Goals; Hospitals; Human; Individual; Israel; K-Series Research Career Programs; Laboratories; Learning; Medical center; Medicine; Mentors; Molecular; Monitor; Neurobiology; Neurology; Neurosciences; Neurosciences Research; Ophthalmology; Participant; Pathology; Pediatric Hospitals; Pediatric Neurology; Physicians; Psychiatry; Publications; Radiology Specialty; Recording of previous events; Research; Research Personnel; Residencies; Resources; Science; Scientist; Training; Training Programs; Translational Research; United States National Institutes of Health; Work; career; design; education research; effectiveness evaluation; experience; improved; insight; medical schools; nervous system disorder; neurosurgery; novel therapeutics; programs; recruit; responsible research conduct; skills; translational neuroscience

Project Summary This competing continuation proposal will provide an opportunity for selected residents in the neurology residency training programs of the Beth Israel Deaconess Medical Center (BIDMC) and Boston Children's Hospital (BCH) to participate for 6 to 36 months in an intensive, mentored, research educational experience during the final year of residency and subsequent fellowship years. This training will be designed to prepare participating residents for successful competition for NIH funded independent mentored research awards, and will facilitate the transition from resident/fellow to clinician-scientist. Each participant will work with one of 57 mentors, who have been recruited from the faculties of BCH, BIDMC, and Harvard Medical School (HMS). All have active NIH funding and a history of training clinician-scientists. The proposed mentors cover all major areas of the clinical and basic neurosciences, and include 30 investigators from BCH, 15 investigators from BIDMC, seven investigators from HMS and five investigators from other Harvard and Harvard Hospital affiliates. Thirty of these investigators are engaged in clinical/translational neuroscience research and forty-two are engaged in basic neuroscience research. Mentors have been drawn not only from the Departments of Neurology/Neurobiology, but also from Divisions/Departments of Anaesthesia, Cell Biology, Genetics, Neurosurgery, Ophthalmology, Pathology, Radiology, Developmental Medicine, and Psychiatry. Selected resident participants will learn state-of-the-art laboratory skills and will acquire the critical expertise necessary for the conduct of responsible research. Data collected and analyzed will serve for publications as well as for future NIH proposals. The program will be governed by a Steering Committee consisting of the PD/PIs, the Department Chairs, and the Residency Directors of the participating residency programs. This Committee will work together to recruit and select trainees, to monitor their progress, and to evaluate the effectiveness of the training experience.

项目摘要 这一竞争性的延续提案将为神经病学中选定的住院医师提供机会 贝丝以色列女执事医疗中心（BIDMC）和波士顿儿童医院的住院医师培训计划 医院（BCH）参加为期6至36个月的密集，指导，研究教育经验 在住院医师的最后一年和随后的奖学金年。本次培训旨在为 参与住院医师成功竞争NIH资助的独立指导研究奖，以及 将促进从住院医师/研究员到临床科学家的过渡。每个参与者将与57个 从BCH、BIDMC和哈佛医学院（HMS）招聘的导师。所有 拥有积极的NIH资金和培训临床科学家的历史。拟议的导师涵盖所有主要的 临床和基础神经科学领域，包括30名来自BCH的研究人员，15名来自 BIDMC、HMS的7名研究者和其他哈佛和哈佛医院的5名研究者 附属机构。这些研究人员中有30人从事临床/转化神经科学研究，42人从事神经科学研究。 从事基础神经科学研究。导师不仅来自 神经学/神经生物学，也来自麻醉，细胞生物学，遗传学， 神经外科、眼科、病理学、放射学、发育医学和精神病学。选择 常驻参与者将学习最先进的实验室技能，并获得必要的关键专业知识 进行负责任的研究。收集和分析的数据将用于出版物以及 国家卫生研究院未来的提案该计划将由一个指导委员会管理，该委员会由PD/PI、 部门主席，和参与居住计划的居住主任。本委员会将 共同招募和挑选学员，监督他们的进展，并评估 培训经验。

项目成果

Biallelic loss of EMC10 leads to mild to severe intellectual disability.

• DOI: 10.1002/acn3.51602
• 发表时间: 2022-07
• 期刊: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
• 影响因子: 5.3
• 作者: Kaiyrzhanov, Rauan;Rocca, Clarissa;Suri, Mohnish;Gulieva, Sughra;Zaki, Maha S.;Henig, Noa Z.;Siquier, Karine;Guliyeva, Ulviyya;Mounir, Samir M.;Marom, Daphna;Allahverdiyeva, Aynur;Megahed, Hisham;van Bokhoven, Hans;Cantagrel, Vincent;Rad, Aboulfazl;Pourkeramti, Alemeh;Dehghani, Boshra;Shao, Diane D.;Markus-Bustani, Keren;Sofrin-Drucker, Efrat;Orenstein, Naama;Salayev, Kamran;Arrigoni, Filippo;Houlden, Henry;Maroofian, Reza
• 通讯作者: Maroofian, Reza

Childhood-onset hereditary spastic paraplegia and its treatable mimics.

• DOI: 10.1016/j.ymgme.2021.06.006
• 发表时间: 2022-12
• 期刊: Molecular genetics and metabolism
• 影响因子: 3.8
• 作者: Ebrahimi-Fakhari D;Saffari A;Pearl PL
• 通讯作者: Pearl PL

Mendelian etiologies identified with whole exome sequencing in cerebral palsy.

• DOI: 10.1002/acn3.51506
• 发表时间: 2022-03
• 期刊: Annals of clinical and translational neurology
• 影响因子: 5.3
• 作者: Chopra M;Gable DL;Love-Nichols J;Tsao A;Rockowitz S;Sliz P;Barkoudah E;Bastianelli L;Coulter D;Davidson E;DeGusmao C;Fogelman D;Huth K;Marshall P;Nimec D;Sanders JS;Shore BJ;Snyder B;Stone SSD;Ubeda A;Watkins C;Berde C;Bolton J;Brownstein C;Costigan M;Ebrahimi-Fakhari D;Lai A;O'Donnell-Luria A;Paciorkowski AR;Pinto A;Pugh J;Rodan L;Roe E;Swanson L;Zhang B;Kruer MC;Sahin M;Poduri A;Srivastava S
• 通讯作者: Srivastava S

Supramammillary glutamate neurons are a key node of the arousal system.

• DOI: 10.1038/s41467-017-01004-6
• 发表时间: 2017-11-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Pedersen NP;Ferrari L;Venner A;Wang JL;Abbott SBG;Vujovic N;Arrigoni E;Saper CB;Fuller PM
• 通讯作者: Fuller PM

The clinical and molecular spectrum of <i>ZFYVE26</i>-associated hereditary spastic paraplegia: SPG15

<i>ZFYVE26</i>相关遗传性痉挛性截瘫的临床和分子谱：SPG15

• DOI: 10.1093/brain/awac391
• 发表时间: 2022
• 期刊: Brain
• 影响因子: 14.5
• 作者: Safari A;Kellner M;Takiyama Y;et al.
• 通讯作者: et al.