Translational and Genomic Pediatric Cancer Epidemiology Training Grant

转化和基因组儿科癌症流行病学培训补助金

• 批准号: 10645200
• 负责人: Logan G. Spector
• 金额: $ 33.01万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10645200
• 关键词: Genomics; Grant; Malignant Childhood Neoplasm; Training; cancer epidemiology

Abstract The University of Minnesota Department of Pediatrics and Masonic Cancer Center propose to continue a highly successful training program in translational and genomic pediatric cancer epidemiology research. Our program is sought nationally ‐by scholars, and provides opportunities for 1 predoctoral and 3 postdoctoral students to enhance their research and experience across a spectrum of pediatric cancer research, with a goal of interdisciplinary cross training. With 19 outstanding mentoring faculty, trainees work in a variety of research settings including classical epidemiology, genomic epidemiology, laboratory studies, and clinical investigations. Along with seminars specific to pediatric cancer, strong graduate school degree programs at the University of Minnesota in Epidemiology (PhD) and in Clinical Research (MS) offer opportunities for courses in epidemiology, cancer epidemiology, biostatistics, bioinformatics, cancer biology, genetic epidemiology, immunology, clinical trials/methods, and field research. Further, students have several unparalleled opportunities for supervised translational and genomic research projects in human, animal, and in vitro data, study design and development, statistical analysis, and individual and team grant writing. Predoctoral students are formally admitted to the graduate school PhD program in Epidemiology. The postdoctoral trainees are drawn from the medical, basic and applied sciences through national advertising and our Masonic Cancer Center members, and from the cohort of medical fellows in the Department of Pediatrics who have completed advanced clinical training in pediatric oncology and are embarking on the research component of their training. Spe‐cial attention is given to recruitment of individuals from underrepresented minorities. We anticipate that two of our postdoctoral trainees will choose to obtain an MS in clinical research. Criteria for selection of both pre and postdoctoral trainees include a strong academic performance and a career orientation toward independent research in an academic, clinical, or public health setting. Each trainee is guided by at least two senior mentors from complementary disciplines in their research projects. All trainees participate in courses in pediatric cancer topics and readings in pediatric cancer epidemiology, weekly pediatric cancer seminar meetings and pediatric tumor conferences, monthly seminars, annual retreats, and presenters of their own research at national meetings. Postdoctoral students receive additional training in grant writing/preparation. All receive instruction in the responsible conduct of research. Trainees who graduate from this program will have the capacity to undertake high impact pediatric cancer research across a spectrum of disciplines.

摘要 明尼苏达大学儿科和共济会癌症中心提议继续一项 在翻译和基因组儿科癌症流行病学研究方面非常成功的培训计划。我们的 该项目由学者在全国范围内寻求，为1名博士后和3名博士后提供机会 学生加强他们在一系列儿科癌症研究方面的研究和经验， 跨学科交叉培训的目标。拥有19名优秀的指导教师，学员在各种不同的 研究环境包括经典流行病学、基因组流行病学、实验室研究和临床 调查。除了专门针对儿科癌症的研讨会，强大的研究生院学位课程也在 明尼苏达大学流行病学(PHD)和临床研究(MS)为 流行病学、癌症流行病学、生物统计学、生物信息学、癌症生物学、遗传学 流行病学、免疫学、临床试验/方法和实地研究。此外，学生们有几个 无与伦比的机会为人类、动物和 体外数据，研究设计和开发，统计分析，个人和团队拨款撰写。 流行病学研究生院博士研究生正式录取博士研究生。这个 博士后实习生来自医学、基础和应用科学，通过国家广告和 我们的共济会癌症中心成员，以及来自儿科的医学研究员队列 已经完成了儿科肿瘤学的高级临床培训并正在着手研究 作为他们训练的一部分。特别注意从任职人数偏低的人员中招聘人员 少数族裔。我们预计我们的两名博士后实习生将选择在临床研究中获得硕士学位。 选择博士后和博士后实习生的标准包括优秀的学习成绩和 在学术、临床或公共卫生领域从事独立研究的职业导向。每位实习生 在他们的研究项目中至少有两名来自互补学科的资深导师指导。所有受训人员 每周参加儿科癌症主题课程和儿科癌症流行病学读物 儿科癌症研讨会会议和儿科肿瘤会议，每月研讨会，年度静修，以及 在国家会议上介绍他们自己的研究成果。博士后学生接受额外的培训 批准写作/准备。所有人都接受负责任的研究行为方面的指导。毕业的实习生 该计划将有能力承担跨光谱的高影响力的儿科癌症研究 纪律的问题。

项目成果

Maternal prenatal cigarette, alcohol and illicit drug use and risk of infant leukaemia: a report from the Children's Oncology Group.

• DOI: 10.1111/j.1365-3016.2011.01229.x
• 发表时间: 2011-11
• 期刊: Paediatric and perinatal epidemiology
• 影响因子: 2.8
• 作者: Slater ME;Linabery AM;Blair CK;Spector LG;Heerema NA;Robison LL;Ross JA
• 通讯作者: Ross JA

Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study.

• DOI: 10.1111/j.2047-6310.2012.00100.x
• 发表时间: 2013-06
• 期刊: Pediatric obesity
• 影响因子: 3.8
• 作者: Linabery AM;Nahhas RW;Johnson W;Choh AC;Towne B;Odegaard AO;Czerwinski SA;Demerath EW
• 通讯作者: Demerath EW

Invited commentary: childhood acute lymphoblastic leukemia and allergies: biology or bias?

特邀评论：儿童急性淋巴细胞白血病和过敏：生物学还是偏见？

• DOI: 10.1093/aje/kws265
• 发表时间: 2012
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Linabery,AmyM;Spector,LoganG
• 通讯作者: Spector,LoganG

Healthcare cost and utilization for chimeric antigen receptor (CAR) T-cell therapy in the treatment of pediatric acute lymphoblastic leukemia: A commercial insurance claims database analysis.

嵌合抗原受体 (CAR) T 细胞疗法治疗儿童急性淋巴细胞白血病的医疗费用和利用：商业保险索赔数据库分析。

• DOI: 10.1002/cnr2.1980
• 发表时间: 2024
• 期刊: Cancer reports (Hoboken, N.J.)
• 作者: Hoover,Alex;Reimche,Paige;Watson,Dave;Tanner,Lynn;Gilchrist,Laura;Finch,Mike;Messinger,YoavH;Turcotte,LucieM
• 通讯作者: Turcotte,LucieM

Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005.

• DOI: 10.1002/cncr.24465
• 发表时间: 2009-09-15
• 期刊: CANCER
• 影响因子: 6.2
• 作者: Ognjanovic, Simona;Linabery, Amy M.;Charbonneau, Bridget;Ross, Julie A.
• 通讯作者: Ross, Julie A.