Pacemakers of Cholinergic Wave Activity in the Developing Retina
视网膜发育中胆碱能波活动的起搏器
基本信息
- 批准号:10653330
- 负责人:
- 金额:$ 42.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressBiomedical ResearchBlood VesselsBrainCalciumCalcium ChannelCellsCommunitiesCritical ThinkingDataDetectionDevelopmentDyesExhibitsEyeFetusFutureGenerationsGoalsHumanImageImmunohistochemistryInjectionsInterneuronsKnowledgeLabelLaboratoriesLeadLearningLocationMapsMediatingMedicineMolecularMonitorMorphologyMusNeurodevelopmental DisorderNeuronsPacemakersPharmacotherapyPhotonsPhysiologicalPremature InfantPrimatesPropertyPublic HealthRecurrenceResearchResearch PersonnelRetinaRetinal Ganglion CellsReverse Transcriptase Polymerase Chain ReactionRoleStudentsSystems DevelopmentTechniquesTestingTransgenic MiceUnited StatesVisionVisualVisual MotionVisual impairmentWorkangiogenesiscalcium indicatorcareercholinergicexperiencegraduate studentnervous system disorderneuralneural circuitneuron developmentnovelpatch clamppharmacologicprenatalretinotopicsegregationskillsstarburst amacrine celltooltwo photon microscopytwo-photonundergraduate studentvision developmentvisual processing
项目摘要
PROJECT SUMMARY
Before the emergence of vision, spontaneous retinal wave activity is essential for retinal layer-specific
angiogenesis and dendritic maturation of retinal ganglion cells, as well as for the refinement of eye-specific
segregations and retinotopic maps. A subpopulation of retinal amacrine interneurons, called starburst amacrine
cells, initiate and propagate retinal waves through recurrent cholinergic connections called cholinergic retinal
waves. However, the mechanisms underlying cholinergic wave initiation and propagation are poorly defined.
Currently, the most urgent priority is to define how cholinergic waves are initiated to create a framework for
understanding their downstream propagation. This project's objective is to identify a subset of starburst amacrine
cells that serve as cholinergic wave pacemakers and the mechanisms by which pacemaker starburst amacrine
cells generate these waves. Preliminary data from the PI's laboratory demonstrate that it is feasible to identify
pacemaker starburst amacrine cells and the sufficiency of a single pacemaker starburst amacrine cell to initiate
a wave. Wave generation requires activation of voltage-dependent calcium channels. These novel findings lead
to the central hypothesis: single pacemaker starburst amacrine cells initiate waves by a calcium-dependent
mechanism. To test this hypothesis, the team will determine the distribution and properties of cholinergic wave
pacemakers (Aim 1), and identify the calcium-dependent mechanisms of cholinergic wave generation (Aim 2).
The work on understanding the identity and features of pacemaker starburst amacrine cells and the ionic
mechanisms of cholinergic retinal wave generation will advance knowledge of how retinal waves mediate
vascular and neuronal development of the retina as well as eye-specific segregation and retinotopic map
refinement in the visual centers of the brain.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dao-Qi Zhang其他文献
Dao-Qi Zhang的其他文献
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{{ truncateString('Dao-Qi Zhang', 18)}}的其他基金
The Underlying Mechanisms of Visual Impairment and Myopia in Prematurity
早产儿视力障碍和近视的潜在机制
- 批准号:
10584723 - 财政年份:2023
- 资助金额:
$ 42.9万 - 项目类别:
Functional organization of the retinal dopaminergic network
视网膜多巴胺能网络的功能组织
- 批准号:
8630381 - 财政年份:2014
- 资助金额:
$ 42.9万 - 项目类别:
Functional organization of the retinal dopaminergic network
视网膜多巴胺能网络的功能组织
- 批准号:
8990483 - 财政年份:2014
- 资助金额:
$ 42.9万 - 项目类别:
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