The Project STAR Healthy Aging Experiment

这笔赠款的目的是获得初步数据，以支持一项将重新联系11,240人的更大规模的研究 一项成功的小班人数多中心随机对照试验的参与者 学生/教师成绩比率(STAR)。这项未来的研究将提供至关重要的信息 儿童早期教育的改变是否能对健康老龄化和危险因素产生积极影响 阿尔茨海默病和阿尔茨海默病相关痴呆(AD/ADRD)。最初的研究，进行了 在1985-1989年间，高中毕业率、大学出勤率、收入、家庭 与对照参与者相比，接受治疗的参与者的所有权、更高的储蓄和更低的犯罪率。因为 这些都是健康的社会决定因素，我们预计它还可以改善参与者的健康和衰老 AD/ADRD的直接危险因素。因此，STAR项目提出了一种潜在的解决方案 美国健康每况愈下的问题。 STAR项目的独特之处不仅是因为它在实验上测试了小班教学的价值，而且 还因为它测试了其他衡量课堂质量的指标，如教师经验。因此，它允许 两个实验合而为一。 我们的短期目标是检查STAR项目是否降低了 治疗组与对照组比较，评估重新联系原始队列的可行性。 我们的长期目标是将STAR计划转变为研究健康的社会决定因素的活队列 通过收集实验室和调查数据，包括生物年龄、老龄化速度和近端风险因素，实现老龄化 适用于AD/ADRD。这项研究的目的是：1)为未来的R01收集初步数据；2)确定 小班规模是否能降低中年的过早死亡率；以及3)发布一个数据集链接 使用NDI将STAR实验数据项目到预期死亡率记录。

The purpose of this grant is to obtain preliminary data to support a larger study that would recontact 11,240 participants of a successful multicenter randomized controlled trial of small class sizes called Project Student/Teacher Achievement Ratio (STAR). This future study would provide critically important information on whether changes to early childhood education can have positive impacts on healthy aging and risk factors for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). The original study, conducted between 1985-1989, produced higher rates of high school graduation, college attendance, earnings, home ownership, higher savings, and lower crime among treated participants relative to control participants. Because these are social determinants of health, we expect that it also improved participants’ health and aging and proximate risk factors for AD/ADRD. Project STAR therefore presents one potential solution to the vexing problem of declining health in the United States. Project STAR is unique not only because it experimentally tests the value of small class size on education, but also because it tests other measures of classroom quality, such as teacher experience. It therefore allows for two experiments in one. Our short-term objectives are to examine whether Project STAR reduced premature mortality for the treatment group relative to the control group and to assess the feasibility of recontacting the original cohort. Our long-term objective is to turn Project STAR into a living cohort to study the social determinants of healthy aging by collecting laboratory and survey data, including biological age, pace of aging and proximal risk factors for AD/ADRD. The aims of the study are: 1) to collect preliminary data for a future R01; 2) to determine whether small class sizes reduce premature mortality in mid-adulthood; and 3) to release a dataset linking Project STAR experimental data to prospective mortality records using NDI.