The Project STAR Healthy Aging Experiment

这笔赠款的目的是获得初步数据，以支持一项更大的研究， 一项成功的多中心随机对照试验的参与者， 学生/教师成绩比率（星星）。这项未来的研究将提供至关重要的信息， 幼儿教育的变化是否会对健康老龄化和风险因素产生积极影响 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）。最初的研究， 在1985-1989年间，高中毕业率、大学入学率、收入、家庭收入 所有权，更高的储蓄，和较低的犯罪率治疗参与者相对于控制参与者。因为 这些都是健康的社会决定因素，我们希望它也能改善参与者的健康和衰老， AD/ADRD的近似风险因素。因此，星星项目为解决这一难题提供了一个潜在的解决方案。 美国健康状况下降的问题。 星星计划的独特之处不仅在于它以实验的方式测试了小班教学的价值， 还因为它测试了其他衡量课堂质量的标准，比如教师的经验。因此，它允许 两个实验合二为一。 我们的短期目标是检查星星项目是否降低了 治疗组相对于对照组，并评估重新联系原始队列的可行性。 我们的长期目标是将星星项目变成一个活的群体，研究健康的社会决定因素， 通过收集实验室和调查数据，包括生物学年龄，衰老速度和近端风险因素， AD/ADRD。本研究的目的是：1）为未来的R 01收集初步数据; 2）确定 小班教学是否会降低中年期的过早死亡率;以及3）发布一个数据集， 利用NDI将星星项目实验数据与预期死亡率记录相结合。

The purpose of this grant is to obtain preliminary data to support a larger study that would recontact 11,240 participants of a successful multicenter randomized controlled trial of small class sizes called Project Student/Teacher Achievement Ratio (STAR). This future study would provide critically important information on whether changes to early childhood education can have positive impacts on healthy aging and risk factors for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). The original study, conducted between 1985-1989, produced higher rates of high school graduation, college attendance, earnings, home ownership, higher savings, and lower crime among treated participants relative to control participants. Because these are social determinants of health, we expect that it also improved participants’ health and aging and proximate risk factors for AD/ADRD. Project STAR therefore presents one potential solution to the vexing problem of declining health in the United States. Project STAR is unique not only because it experimentally tests the value of small class size on education, but also because it tests other measures of classroom quality, such as teacher experience. It therefore allows for two experiments in one. Our short-term objectives are to examine whether Project STAR reduced premature mortality for the treatment group relative to the control group and to assess the feasibility of recontacting the original cohort. Our long-term objective is to turn Project STAR into a living cohort to study the social determinants of healthy aging by collecting laboratory and survey data, including biological age, pace of aging and proximal risk factors for AD/ADRD. The aims of the study are: 1) to collect preliminary data for a future R01; 2) to determine whether small class sizes reduce premature mortality in mid-adulthood; and 3) to release a dataset linking Project STAR experimental data to prospective mortality records using NDI.