Discordance in chromosomal and self-reported sex in the UK Biobank: Implications for transgender- and intersex-inclusive data collection.
Discordance in chromosomal and self-reported sex in the UK Biobank: Implications for transgender- and intersex-inclusive data collection.
复制标题
DOI：
10.1073/pnas.2218700120
复制
发表时间：
2023-05-02
影响因子：
11.1
通讯作者：
Duchowny, Kate A.
中科院分区：
文献类型：
--
作者：
Ackley, Sarah F.;Zimmerman, Scott C.;Flatt, Jason D.;Riley, Alicia R.;Sevelius, Jae;Duchowny, Kate A.
尽管近期有人呼吁区分性（sex）和性别（gender），但这些概念常常被孤立地评估，或者被交替使用。我们的研究对染色体性别和自我报告性别之间的不一致进行了量化，并利用英国生物银行的数据确定了不一致的潜在原因。我们表明，在大约200名性别不一致的个体中，71%的不一致可由双性特征或跨性别身份来解释。这些发现意味着健康和临床研究人员拥有一个独特的机会，既能提高科学研究的严谨性，又能促进跨性别、双性以及非二元性别人群的健康和福祉，这些人群长期被临床和调查研究排除在外且被忽视。
区分性和性别变得日益重要。性在出生时就被确定，而性别是社会构建的，可能与一个人被指定的性不相符。然而，在大多数研究中，性或性别被孤立地评估，或者这些术语被交替使用，这对研究的准确性和包容性有影响。我们利用英国生物银行的数据来量化染色体性别和自我报告性别之间不一致的发生率，并确定不一致的潜在原因。在大约200名性别不一致的个体中，71%的不一致可能由双性特征或跨性别身份的存在来解释。研究结果表明，在描述健康方面的性和/或性别特定差异时，研究人员在得出有关特定性和/或性别健康信息的结论方面可能能力有限。
Despite recent calls to distinguish between sex and gender, these constructs are often assessed in isolation or are used interchangeably. Our study quantifies the disagreement between chromosomal and self-reported sex and identifies potential reasons for discordance using data from the UK Biobank. We show that among approximately 200 individuals with sex discordance, 71% of discordances were explained by intersex traits or transgender identity. These findings imply that health and clinical researchers have a unique opportunity to advance the rigor of scientific research as well as the health and well-being of transgender, intersex, and nonbinary people, who have long been excluded from and overlooked in clinical and survey research. There is growing need to distinguish between sex and gender. While sex is assigned at birth, gender is socially constructed and may not correspond to one’s assigned sex. However, in most research studies, sex or gender is assessed in isolation or the terms are used interchangeably, which has implications for research accuracy and inclusivity. We used data from the UK Biobank to quantify the prevalence of disagreement between chromosomal and self-reported sex and identify potential reasons for discordance. Among approximately 200 individuals with sex discordance, 71% of discordances were potentially explained by the presence of intersex traits or transgender identity. The findings indicate that when describing sex- and/or gender-specific differences in health, researchers may be limited in their ability to draw conclusions regarding specific sex and/or gender health information.
登录
查看更多内容
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
12.7
作者：
Meerwijk, Esther L.;Sevelius, Jae M.
通讯作者：
Sevelius, Jae M.
影响因子：
3.5
作者：
Lagos, Danya
通讯作者：
Lagos, Danya
影响因子：
6.8
作者：
Marioni RE;Harris SE;Zhang Q;McRae AF;Hagenaars SP;Hill WD;Davies G;Ritchie CW;Gale CR;Starr JM;Goate AM;Porteous DJ;Yang J;Evans KL;Deary IJ;Wray NR;Visscher PM
通讯作者：
Visscher PM
影响因子：
4.7
作者：
Kcomt, Luisa;Gorey, Kevin M.;McCabe, Sean Esteban
通讯作者：
McCabe, Sean Esteban