Rapid Response to Incident HIV Infection through Social Network Strategies and Molecular Epidemiology to Inform Partner Services

通过社交网络策略和分子流行病学快速响应艾滋病毒感染事件，为合作伙伴服务提供信息

• 批准号: 10653195
• 负责人: Ann Dennis
• 金额: $ 71.97万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10653195
• 关键词: AIDS prevention; Acute; Address; Advocate; Anti-Retroviral Agents; Area; Behavior; Behavioral; Biological; Caring; Cluster Analysis; Collaborations; Contact Tracing; County; Data; Detection; Development; Diagnosis; Disparity; Drug usage; Ensure; Epidemic; Epidemiology; Evaluation; Friends; Genetic; Goals; HIV; HIV Infections; HIV Seropositivity; HIV diagnosis; Human immunodeficiency virus test; Incidence; Individual; Infection; Intervention; Investigation; Knowledge; Link; Logistics; Methods; Molecular Epidemiology; Names; Newly Diagnosed; North Carolina; Notification; Outcome; Pathway Analysis; Persons; Pharmaceutical Preparations; Prevention; Public Health; Quasi-experiment; Reporting; Research; Resources; Risk; Rural; Sequence Analysis; Services; Sexual Partners; Sexual and Gender Minorities; Social Network; Social support; Source; South Carolina; Testing; United States; Viral; Virus; black men who have sex with men; case finding; community engagement; community involvement; design; distrust; effectiveness evaluation; effectiveness outcome; epidemic response; evidence base; experience; gender minority group; high risk; high risk population; hybrid type 1 design; implementation outcomes; implementation strategy; improved; indexing; innovation; member; metropolitan; multidisciplinary; next generation; peer; post intervention; pre-exposure prophylaxis; prevention service; recruit; response; rural area; rural counties; service engagement; service intervention; service utilization; sex; social; social contact; social stigma; standard of care; success; tool; transgender women; transmission process; treatment services; uptake; urban area

PROJECT SUMMARY The objective of the proposed research is to improve the response to incident HIV infection by engaging the networks of Black men who have sex with men (BMSM) and transgender women (TGW) through a combination of Partner Services, social network recruitment, and HIV genetic cluster detection. Despite marked advances in HIV treatment and prevention, HIV incidence has not substantially declined among BMSM/TGW in the Southern United States (US), highlighting the need for innovative methods to detect and respond to ongoing HIV transmission. While Partner Services can be highly effective, case finding remains limited even for persons diagnosed soon after HIV acquisition (acute or recent infections). Partner Services can also be limited in investigations across jurisdictional boundaries and in rural areas. We hypothesize that leveraging the social networks (social contacts rather than only drug sharing or sexual partners) of networks with recent HIV transmission will lead to improved engagement in HIV services (prevention or care). However, such strategies must be responsive to the barriers and facilitators to engagement in these services including a better understanding of social support networks. This project involves a multidisciplinary team including robust public health partnerships and active community engagement to address HIV prevention needs and build on existing resources. We will develop and implement an enhanced social network strategy (eSNS) for networks of BMSM/TGW with new HIV diagnoses, including acute incident infection, in the high-burden Charlotte region (Mecklenburg County, North Carolina), situated on the border of South Carolina. Both areas are priority regions in the Ending the Epidemic (EHE) initiative. In the eSNS intervention, new diagnoses will receive rapid response Partner Services for elicitation of social and sexual contacts; selected contacts will be recruited and coached to recruit their peers to engage in HIV services. Aim 1 will employ regional genetic and contact network analysis of incident and prevalent HIV in North and South Carolina, to evaluate important connections (bridging) between states and between urban and rural areas. This granular data (contact, spatial, genetic) will expand epidemiological understanding of the epidemic to inform development of the eSNS and enhance local EHE strategies. To further inform eSNS development, Aim 2 will use a mixed methods approach to examine the barriers and facilitators of engaging BMSM/TGW members of networks with recent HIV transmission. Aim 3 will then evaluate the eSNS with effectiveness and implementation outcomes. Effectiveness outcomes (increase in testing, pre-exposure prophylaxis referral, and HIV care engagement) will be evaluated with regression point displacement design comparing outcomes pre/post intervention in Charlotte and in comparison, with the Raleigh region receiving standard of care partner services. Overall, the results of this project will lead to critical information to guide new strategies in Partner Services and in EHE responses to increase HIV care and prevention engagement among BMSM/TGW in the Southern US.

项目总结

项目成果

Interrupting HIV transmission networks: how can we design and implement timely and effective interventions?

阻断艾滋病毒传播网络：我们如何设计和实施及时有效的干预措施？

• DOI: 10.1080/14787210.2023.2221850
• 发表时间: 2023
• 期刊: Expert review of anti-infective therapy
• 影响因子: 5.7
• 作者: Dennis,AnnM;Mobley,Victoria
• 通讯作者: Mobley,Victoria