Core A: Administrative Core

项目摘要 行政核心负责全面领导和管理计划项目赠款 (P01)实行全面的组织管理、行政管理和科学管理。行政 核心将监督和协调所有P01组件，并集中监控和评估其性能。在 此外，行政核心将促进与内部咨询委员会（IAB）和外部 顾问委员会（EAB）。P01申请涉及6个机构和5个主要研究者，作为项目和核心 领导人的人选信号行政核心在协调所有通信和审查所有活动方面至关重要 在项目和核心之间，将在参与机构之间进行。行政核心将 管理所有分包合同，与所有参与机构密切合作，以利用现有设施， 在需要时，在这些基础上建立，并确保动物研究和人类受试者研究的最佳实践 得到适当的满足和监测。它还将确保获得所有科学核心设施服务， 以确保实现P01的总体目标。行政核心人员将领导 由Lathia博士与Barnholtz-Sloan和Waite博士以及Schiciano女士合作编写。Lathia医生和 Barnholtz-Sloan在管理多机构项目方面拥有丰富的经验。建议的P01团队 在多项合作努力中共同努力的成功记录。具体目标 为P01项目和核心提供所有组织、行政和科学领导， 通过创新和卓越，利用资源， 建设性反馈; 2）为P01的所有财务管理提供行政管理，包括 但不限于赠款资金的会计、进度报告、通信、会议安排和会议记录， 以及手稿和基金准备; 3）通过口头和书面文件评估研究进展， 与IAB，EAB和国家癌症研究所（NCI）领导层的定期投入，以确保每个 项目在拟议的时间框架内实现其目标; 4）确保和监测以下方面的最佳做法： 所有P01项目和核心的人类受试者和动物研究;数据操作（与 生物统计学和生物信息学核心）;以及为所有项目提供充足的人类和动物生物标本（ 与实验模型核心合作）;以及5）通过促进 研讨会、招聘博士后研究员、科学交流、协调年度科学务虚会 参与P01的科学家，并通过培训和发展计划，确保最先进的 实践

PROJECT SUMMARY The Administrative Core is responsible for the overall leadership and management of the Program Project Grant (P01), and it will provide overall organizational, administrative, and scientific management. The Administrative Core will oversee and coordinate all P01 components and centrally monitor and evaluate their performance. In addition, the Administrative Core will facilitate all interactions with the Internal Advisory Board (IAB) and External Advisory Board (EAB). This P01 application involves 6 institutions and 5 key investigators, as Project and Core leaders. The Administrative Core will be essential in coordinating all communications and reviewing all activities among Projects and Cores that will take place across the participating institutions. The Administrative Core will administer all the subcontracts, work closely with all participating institutions in order to use existing facilities and build upon those when required, and ensure that best practices for animal studies and human subjects research are met and monitored appropriately. It will additionally ensure that access to all scientific core facility services are managed to ensure that the overall goals of the P01 are met. The Administrative Core personnel will be led by Dr. Lathia, with collaboration from Drs. Barnholtz-Sloan and Waite and Ms. Schiciano. Both Drs. Lathia and Barnholtz-Sloan have extensive experience in managing multi-institution programs. The proposed P01 team has a successful record of accomplishment of working together on multiple collaborative efforts. The Specific Aims are:1) To provide all organizational, administrative, and scientific leadership for the P01 Projects and Cores by cultivating and promoting the P01 team through innovation and excellence, leveraging resources, and providing constructive feedback; 2) To provide administrative management for all fiscal management of the P01 including but not limited to accounting of grant funds, progress reports, communication, meeting scheduling and minutes, and manuscript and grant preparation; 3) To evaluate research progress through oral and written documentation, with regular input from the IAB, EAB, and National Cancer Institute (NCI) leadership in order to ensure that each project is meeting its objectives within the proposed time frame; 4) To ensure and monitor best practices for human subjects and animal research for all P01 Projects and Cores; data operations (in collaboration with the Biostatistics and Bioinformatics Core); and adequate human and animal biospecimens for all projects (in collaboration with the Experimental Models Core); and 5) To raise awareness of the P01 through promotion of seminars, recruitment of postdoctoral fellows, scientific exchanges, coordination of an annual scientific retreat involving the scientists in the P01, and through training and development plans that will ensure state-of-the-art practices.