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Neural basis of trans-saccadic perception

跨眼跳知觉的神经基础

基本信息

批准号：
10653067
负责人：
JUDE F MITCHELL
金额：
$ 38.23万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10653067
关键词：
Address Animal Model Animals Area Attention Behavior Callithrix Callithrix jacchus jacchus Code Complex Cues Evaluation Exhibits Eye Eye Movements Genetic study Human Image Impairment Link Location Maps Measures Methods Modeling Molecular Monkeys Motion Motor Neurodevelopmental Disorder Neurons Noise Parietal Perception Peripheral Population Primates Property Research Resolution Rodent Model Role Saccades Sampling Schizophrenia Sensory Silicon Slide Stimulus Surface Testing Time Vision Visual Visual Acuity Visual Cortex Visual Perception Work area MT area V1 area striata attentional modulation autism spectrum disorder cognitive process density expectation experimental study feature selection fovea centralis functional magnetic resonance imaging/electroencephalography human disease human model improved nervous system disorder neural neural circuit neuromechanism neurophysiology novel optogenetics rapid eye movement receptive field response selective attention sensory cortex tool virtual visual information visual processing

项目摘要

Project Summary Human vision relies on rapid eye movements called saccades that occur a few times every second. These saccades bring peripherally identified objects to the fovea for high resolution inspection. This split-second sampling of the world defines the perception-action cycle of natural vision and profoundly impacts perception. While much is known about the neural mechanisms involved in the onset of this cycle, how targets are selected before saccades, virtually nothing is known about how pre-saccadic representations would impact processing of post-saccadic information about targets that now appear at the fovea. The proposed research addresses fundamental questions about how pre- and post-saccadic visual information are combined across saccades to maximize information for attended targets. Experiments will be performed in the common marmoset, a New World primate whose smooth cortex affords advantages for recording with high-density silicon arrays across cortical representations and in the longer term for imaging and optogenetic manipulation of large scale neural circuits. In Aim 1, we will test if pre-saccadic information is enhanced in early visual cortex to favor higher acuity information that is most relevant to the fovea and thus could provide a “foveal preview” to prime post- saccadic processing. In Aim 2 we test if pre-saccadic enhancement is target specific and involves a selection of target features, such as orientation or motion. In Aim 3 we record from foveal populations in early visual cortex to determine how pre-saccadic selection alters post- saccadic processing, and specifically, if pre-saccadic feature selection of the target biases processing to favor the continued selection of the target at the fovea based on increasing gain for its features. This research will provide the first evaluation at the level of single neurons and neural codes of post-saccadic foveal enhancement and the role of pre-saccadic target selection. This has broader impacts for understanding attention under natural viewing conditions where the eyes parse visual scenes, and more generally, for how sensory-motor predictions influence visual perception.

项目摘要人类的视觉依赖于快速的眼球运动，称为扫视，每隔一段时间发生几次。一下这些扫视将外围识别的对象带到中央凹以获得高分辨率检查这种对世界的瞬间采样定义了自然的感知-动作周期视觉和深刻影响感知。虽然我们对大脑的神经机制参与了这个周期的开始，在扫视之前如何选择目标，实际上没有什么是关于扫视前表示将如何影响扫视后表示的处理，关于现在出现在中央凹处的目标的信息。拟议的研究涉及关于扫视前和扫视后视觉信息如何结合的基本问题以最大限度地为关注的目标提供信息。实验将在普通的绒猴，一种新大陆的灵长类动物，其光滑的皮层为记录与高密度硅阵列在整个皮层代表，并在长期用于大规模神经回路的成像和光遗传学操纵。在目标1中，我们将测试前扫视信息在早期视觉皮层中增强以有利于更高敏锐度信息这与中央凹最相关，因此可以提供“中央凹预览”，扫视加工在目标2中，我们测试扫视前增强是否是目标特异性的，涉及目标特征的选择，例如方向或运动。在目标3中，我们记录了早期视皮质中的中央凹群体，以确定眼跳前选择如何改变眼跳后选择扫视处理，并且具体地，如果目标偏差的扫视前特征选择基于增加的增益而有利于在中央凹处继续选择目标的处理因为它的特点。这项研究将首次在单个神经元水平上进行评估，扫视后中央凹增强的神经编码和扫视前目标选择的作用。这对理解自然观看条件下的注意力有更广泛的影响，眼睛解析视觉场景，更一般地说，用于感觉运动预测如何影响视觉感知

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fast prediction in marmoset reach-to-grasp movements for dynamic prey.

快速预测狨猴抓取动态猎物的动作。

DOI：
10.1016/j.cub.2023.05.032
发表时间：
2023
期刊：
Current biology : CB
影响因子：
0
作者：
Shaw,Luke;Wang,KuanHong;Mitchell,Jude
通讯作者：
Mitchell,Jude

Detailed characterization of neural selectivity in free viewing primates.

DOI：
10.1038/s41467-023-38564-9
发表时间：
2023-06-20
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Yates, Jacob L.;Coop, Shanna H.;Sarch, Gabriel H.;Wu, Ruei-Jr;Butts, Daniel A.;Rucci, Michele;Mitchell, Jude F.
通讯作者：
Mitchell, Jude F.

Electrophysiology of Laminar Cortical Activity in the Common Marmoset.

普通狨猴层状皮质活动的电生理学。