Core 2: Methodology

项目概要：方法核心 本核心侧重于经济评估方法、工具和措施，以支持新的和现有的 跨学科研究合作。尽管数十年的研究支持慢性病治疗方法， 对于吸毒障碍治疗和康复，吸收和维持仍然很低。一些最 阻碍采用循证实践的重要因素是对潜在负担的担忧， 工作人员和其他资源以及总体预算影响。改变目前的做法不仅需要 临床证据，但也要考虑额外的费用和现有资源的重新分配， 结果来自变化。经济分析可以通过提供详细的 更新服务提供商的成本核算，并更广泛地告知“真实世界”资源 通过向政策制定者和支付者提供有关净经济和健康状况的证据， 新办法的影响及其长期财政可行性。这需要考虑成本和 新的干预措施的后果，往往使用成本效益或成本效益分析框架。的 CHERISH（物质使用障碍治疗干预卫生经济学中心， 丙型肝炎病毒和艾滋病毒）是发展和传播经济证据，告知物质使用障碍政策 以及对使用药物的人的HCV和HIV护理。在此更新期间，我们将扩大我们的重点， 在个人、系统和社区层面进行的成果和实施研究， 以下具体目标：1）指导研究人员设计，实施和解释 药物使用障碍治疗的经济分析，以及使用者中的HCV和HIV 2）开发和应用支持物质使用经济评估的方法 使用药物的人中的丙型肝炎病毒和艾滋病毒，重点是实施干预措施 适应性干预。通过CHERISH咨询服务和研究联盟计划，我们 将有助于制定具有明确经济目标的新赠款提案，并将继续 与全国合格的研究人员联系并提供建议，以确保计划经济分析 在方法上是合理的和可行的。我们将扩大CHERISH研究联盟计划，使其能够 作为一个具有全国代表性的虚拟社区，为从事物质使用障碍的研究人员提供服务。 医疗卫生经济研究。使用现有研究并整合第三方数据 数据集和行政记录，我们将开发分析框架和工具，用于评估个人 和系统层面的药物使用障碍及相关的实施干预措施。我们还将开发 适应性干预措施的经济评价方法。与人口数据和建模 核心，我们将协助研究人员使用外部数据，以加强对经济评价的解释 结果

PROJECT SUMMARY: Methodology Core This Core focuses on economic evaluation approaches, tools, and measures to support new and existing interdisciplinary research collaborations. Despite decades of research supporting a chronic disease approach to substance use disorder treatment and recovery, uptake and sustainment remain low. Some of the most important factors inhibiting adoption of evidence-based practices are concerns about the potential burden on staff and other resources, as well as overall budget impact. Changing current practices requires not only clinical evidence, but also consideration of additional costs and the reallocation of existing resources that will result from the changes. Economic analysis can directly address these issues by providing a detailed accounting of the costs to the provider of updating services, and more broadly inform “real-world” resource allocation decisions by providing policymakers and payers with evidence on the net economic and health impact of new approaches and their fiscal viability over time. This requires considering both costs and consequences of a new intervention, often using a cost-effectiveness or cost-benefit analysis framework. The overall aim of CHERISH (Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV) is to develop and disseminate economic evidence that informs substance use disorder policy and HCV and HIV care of people who use substances. In this renewal period we will expand our focus to outcome and implementation research that is conducted at the individual, system, and community levels with the following specific aims: 1) to guide researchers in the design, implementation, and interpretation of economic analyses of treatment for substance use disorder, and HCV and HIV among people who use substances, and 2) to develop and apply methods that support economic evaluations for substance use disorder, and HCV and HIV among people who use substances with a focus on intervention implementation and adaptive interventions. Through the CHERISH Consultation Service and Research Affiliates Program, we will contribute to the development of new grant proposals with explicit economic aims, and will continue to connect with and advise qualifying researchers nationally to ensure that planned economic analyses are methodologically sound and feasible. We will expand the CHERISH Research Affiliates program so it can serve as a nationally-representative virtual community for researchers engaged in substance use disorder treatment health economic research. Working with existing studies and integrating data from third-party datasets and administrative records, we will develop analytic frameworks and tools for evaluating individual and systems-level substance use disorder and related implementation interventions. We will also develop economic evaluation methods for adaptive interventions. In collaboration with the Population Data & Modeling Core, we will assist researchers in using external data to enhance interpretation of economic evaluation results.