The fungiform papilla as a multi-sensory end-organ
菌状乳头作为多感觉终末器官
基本信息
- 批准号:10654839
- 负责人:
- 金额:$ 39.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:Afferent NeuronsAmyloid beta-ProteinAnatomyAttentionBehaviorBinding ProteinsBrain StemBurning Mouth SyndromeC FiberCell NucleusCentral Nervous SystemCharacteristicsCodeCreamDataElectrophysiology (science)EpitheliumEsthesiaFiberFoodFungiform PapillaGene ExpressionGenesGeneticGenetic IdentityGenetic MarkersGoalsHousingImageLateralLightLiquid substanceLocationMechanoreceptorsMediatingModalityMucous MembraneMusNerve Growth Factor ReceptorsNeuronsNeurotrophic Tyrosine Kinase Receptor Type 3OralOral cavityOrganParvalbuminsPerceptionPeripheralPeripheral Nervous System DiseasesPotatoPropertyProprioceptorResearchRodentRoleSensorySkinSmell PerceptionStimulusStructureStructure of trigeminal ganglionSurfaceSynapsesTaste BudsTaste PerceptionTemperatureTestingTextureThermoreceptorsTongueTouch sensationTrigeminal NucleiTrigeminal SystemViralawakeexperienceexperimental studyfeedingmechanical stimulusmultimodalitymultisensorynerve supplyolfactory stimulusoptogeneticsoral sensorypostsynaptic neuronsreceptive fieldrepairedresponsesomatosensorytaste stimulitongue papillatool
项目摘要
Project Summary/Abstract
Our perception of food in the mouth is a multi-modal sensory experience involving taste, olfaction, and
somatosensation. All of these stimuli combine to contribute to the recognition and palatability of food. The first
step leading to the perception of ‘mouth feel” in the oral cavity is activation of peripheral somatosensory
neurons. Multiple classes of these trigeminal somatosensory neurons innervate the oral cavity and can be
defined by the types of stimuli to which they respond. For example, low threshold mechanoreceptors (LTMRs)
carry information concerning touch or mechanical stimuli. In skin, at least 7 clear subtypes of these neurons
have been defined by using gene expression to relate the anatomical features of these neurons with their
functions. We do not know how many specialized neuron subtypes mediate touch sensation in the tongue or
their specialized anatomical and functional properties. Understanding the sensations evoked by a food
stimulus requires us to determine the unique anatomical and functional properties of each LTMR subtype in the
tongue. Equally important is how each LTMR’s activities are integrated with other oral sensory neuron types
(i.e. taste and temperature). Toward these long-term goals we propose to use two genetic identifiers to
examine trigeminal neuron subtypes innervating the fungiform (taste) papillae. Our Aims specifically test the
following hypotheses: 1) Taste papillae are innervated by a Aβ LTMRs with a small receptive fields that
express the neurotrophin receptor, TrkC, and that they neurons can further be divided into rapidly adapting and
slowly-adapting types based on the presence or absence of Parvalbumin. 2) These Aβ LTMRs project to the to
a region of the brainstem immediately adjacent to the primary taste terminal field where they activate
postsynaptic neurons that are responsive to touch. 3) These Aβ LTMRs are capable of modulating responses
to taste stimuli at the first gustatory synaptic relay. Successful completion of these experiments establishes the
fungiform papilla as a mechanosensory end organ and provides the genetic tools to explore the contribution of
a specific subtype of LTMR in the integration of sensations produced by the multi-modal food stimulus.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Joseph Michael Breza其他文献
Joseph Michael Breza的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Joseph Michael Breza', 18)}}的其他基金
The fungiform papilla as a multi-sensory end-organ
菌状乳头作为多感觉终末器官
- 批准号:
10443080 - 财政年份:2022
- 资助金额:
$ 39.95万 - 项目类别:
The fungiform papilla as a multi-sensory end-organ
菌状乳头作为多感觉终末器官
- 批准号:
10833287 - 财政年份:2022
- 资助金额:
$ 39.95万 - 项目类别:
Modulation of Peripheral Gustatory Neurons by Organic Salts and Organic Acids
有机盐和有机酸对周围味觉神经元的调节
- 批准号:
7809341 - 财政年份:2009
- 资助金额:
$ 39.95万 - 项目类别:
Modulation of Peripheral Gustatory Neurons by Organic Salts and Organic Acids
有机盐和有机酸对周围味觉神经元的调节
- 批准号:
8134345 - 财政年份:2009
- 资助金额:
$ 39.95万 - 项目类别:
相似海外基金
Development of prevention of Alzheimer's disease using transgenic soybean expressing amyloid beta protein
使用表达β淀粉样蛋白的转基因大豆预防阿尔茨海默病的进展
- 批准号:
19K07989 - 财政年份:2019
- 资助金额:
$ 39.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Collaborative Research: Dynamics of surfactant - amyloid-beta protein interactions during self-assembly
合作研究:自组装过程中表面活性剂 - 淀粉样蛋白 - β 蛋白相互作用的动力学
- 批准号:
1802641 - 财政年份:2018
- 资助金额:
$ 39.95万 - 项目类别:
Standard Grant
Collaborative Research: Dynamics of surfactant - amyloid-beta protein interactions during self-assembly
合作研究:自组装过程中表面活性剂 - 淀粉样蛋白 - β 蛋白相互作用的动力学
- 批准号:
1802588 - 财政年份:2018
- 资助金额:
$ 39.95万 - 项目类别:
Standard Grant
Collaborative Research: Dynamics of surfactant - amyloid beta protein interactions during self-assembly
合作研究:自组装过程中表面活性剂-淀粉样β蛋白相互作用的动力学
- 批准号:
1802793 - 财政年份:2018
- 资助金额:
$ 39.95万 - 项目类别:
Standard Grant
Analysis of a new mechanism to specifically inhibit amyloid-beta protein production
特异性抑制β-淀粉样蛋白产生的新机制分析
- 批准号:
18K14883 - 财政年份:2018
- 资助金额:
$ 39.95万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Aggregation of amyloid-beta protein on size-controlled lipid nanoparticles
淀粉样β蛋白在尺寸控制的脂质纳米颗粒上的聚集
- 批准号:
16K18860 - 财政年份:2016
- 资助金额:
$ 39.95万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Structure and molecular interactions in aggregation of amyloid beta protein
β淀粉样蛋白聚集的结构和分子相互作用
- 批准号:
26860020 - 财政年份:2014
- 资助金额:
$ 39.95万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
A novel therapeutic strategy for Alzheimer's disease based on the promotion of clearance mechanism of amyloid beta protein
基于促进β淀粉样蛋白清除机制的阿尔茨海默病新治疗策略
- 批准号:
26670126 - 财政年份:2014
- 资助金额:
$ 39.95万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Amyloid Beta-Protein: Wild Type and Familial Mutant Assembly and Inhibition
β-淀粉样蛋白:野生型和家族突变体的组装和抑制
- 批准号:
8728102 - 财政年份:2013
- 资助金额:
$ 39.95万 - 项目类别:
Amyloid Beta-Protein: Wild Type and Familial Mutant Assembly and Inhibition
β-淀粉样蛋白:野生型和家族突变体的组装和抑制
- 批准号:
9110110 - 财政年份:2013
- 资助金额:
$ 39.95万 - 项目类别: