Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements

开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求

基本信息

  • 批准号:
    10654060
  • 负责人:
  • 金额:
    $ 98.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce chronic opioid dependency among surgical patients have become major concerns for surgeons and anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately, existing nociceptive monitoring tools use indicators that are inherently susceptible to intraoperative influences. Monitoring these indicators often lead to suboptimal intraoperative opioid administration, since there is no way to account for whether these measures are being influenced by nociception or numerous other intraoperative factors such as blood loss, anesthetic drugs and antihypertensives. Therefore, improved methods to monitor surgical nociception are clearly needed. In short, currently available nociceptive monitors measure unreliable indicators and predispose surgical patients to suboptimal opioid dosing administration leading to ineffective intraoperative control. The consequences for surgical patients can be significant, since increased postoperative pain and opioid requirements is associated with increased incidence of opioid dependency. This project proposes to develop a state-of-the-art sensors, algorithms, and prospective observational data to construct an integrated measure of nociceptive control based on autonomic (EDA) and neurophysiologic markers of arousal and nociception (EEG-based arousal and opioid signatures).
项目总结

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association of Intraoperative Opioid Administration With Postoperative Pain and Opioid Use.
  • DOI:
    10.1001/jamasurg.2023.2009
  • 发表时间:
    2023-08-01
  • 期刊:
  • 影响因子:
    16.9
  • 作者:
    Mercado, Laura A. Santa Cruz A.;Liu, Ran;Bharadwaj, Kishore M.;Johnson, Jasmine J.;Gutierrez, Rodrigo;Das, Proloy;Balanza, Gustavo;Deng, Hao;Pandit, Akriti;Stone, Tom A. D.;Macdonald, Teresa;Horgan, Caroline;Tou, Si Long (Jenny);Houle, Timothy T.;Bittner, Edward A.;Purdon, Patrick L.
  • 通讯作者:
    Purdon, Patrick L.
Development and prospective validation of postoperative pain prediction from preoperative EHR data using attention-based set embeddings.
  • DOI:
    10.1038/s41746-023-00947-z
  • 发表时间:
    2023-11-16
  • 期刊:
  • 影响因子:
    15.2
  • 作者:
  • 通讯作者:
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Tuan Le Mau其他文献

Tuan Le Mau的其他文献

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{{ truncateString('Tuan Le Mau', 18)}}的其他基金

Developing Active Stimulation and Monitoring Technologies to Optimize Pain and Nociception Management During Regional Anesthesia, General Anesthesia, and Post-Operative Care
开发主动刺激和监测技术,以优化区域麻醉、全身麻醉和术后护理期间的疼痛和伤害感受管理
  • 批准号:
    10604993
  • 财政年份:
    2023
  • 资助金额:
    $ 98.18万
  • 项目类别:
Developing a novel system combining cognitive assessment with PASCALL FDA-cleared intraoperative anesthesia EEG brain monitor to prevent postoperative neurocognitive disorders in aging patients
开发一种将认知评估与 FDA 批准的 PASCALL 术中麻醉脑电图脑监测仪相结合的新型系统,以预防老年患者术后神经认知障碍
  • 批准号:
    10760816
  • 财政年份:
    2023
  • 资助金额:
    $ 98.18万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10360566
  • 财政年份:
    2021
  • 资助金额:
    $ 98.18万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10303200
  • 财政年份:
    2021
  • 资助金额:
    $ 98.18万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10595838
  • 财政年份:
    2020
  • 资助金额:
    $ 98.18万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10157621
  • 财政年份:
    2020
  • 资助金额:
    $ 98.18万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    9909360
  • 财政年份:
    2020
  • 资助金额:
    $ 98.18万
  • 项目类别:
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