Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements

开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药，以尽量减少术后阿片类药物的需求

• 批准号: 10595838
• 负责人: Tuan Le Mau
• 金额: $ 99.48万
• 依托单位: PASCALL SYSTEMS, INCORPORATED
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10595838
• 关键词: Algorithms; Americas; Analgesics; Anesthesia procedures; Anesthetics; Antihypertensive Agents; Applications Grants; Arousal; Blood Pressure; Caring; Chronic; Clinical; Clinical Data; Data; Dose; Electroencephalogram; Electroencephalography; Galvanic Skin Response; General Anesthesia; Heart Rate; Hemorrhage; Incidence; Lead; Length of Stay; Light; Measures; Methods; Monitor; Morphine; Nociception; Nociceptive Stimulus; Operative Surgical Procedures; Opiate Addiction; Opioid; Opioid Analgesics; Outcome; Patients; Pharmaceutical Preparations; Phase; Physiological; Postoperative Pain; Postoperative Period; Process; Public Health; Regulatory Pathway; Risk Factors; Small Business Technology Transfer Research; Surgeon; System; Time; Uncertainty; Ventilatory Depression; base; central sensitization; cognitive recovery; demographics; design; feature extraction; improved; indexing; neurophysiology; new technology; novel; opioid epidemic; opioid overdose; pain score; prescription opioid; product development; prospective; response; sensor; signal processing; tool; wireless sensor

PROJECT SUMMARY In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce chronic opioid dependency among surgical patients have become major concerns for surgeons and anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately, existing nociceptive monitoring tools use indicators that are inherently susceptible to intraoperative influences. Monitoring these indicators often lead to suboptimal intraoperative opioid administration, since there is no way to account for whether these measures are being influenced by nociception or numerous other intraoperative factors such as blood loss, anesthetic drugs and antihypertensives. Therefore, improved methods to monitor surgical nociception are clearly needed. In short, currently available nociceptive monitors measure unreliable indicators and predispose surgical patients to suboptimal opioid dosing administration leading to ineffective intraoperative control. The consequences for surgical patients can be significant, since increased postoperative pain and opioid requirements is associated with increased incidence of opioid dependency. This project proposes to develop a state-of-the-art sensors, algorithms, and prospective observational data to construct an integrated measure of nociceptive control based on autonomic (EDA) and neurophysiologic markers of arousal and nociception (EEG-based arousal and opioid signatures).

项目总结