Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements

开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求

基本信息

  • 批准号:
    10595838
  • 负责人:
  • 金额:
    $ 99.48万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce chronic opioid dependency among surgical patients have become major concerns for surgeons and anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately, existing nociceptive monitoring tools use indicators that are inherently susceptible to intraoperative influences. Monitoring these indicators often lead to suboptimal intraoperative opioid administration, since there is no way to account for whether these measures are being influenced by nociception or numerous other intraoperative factors such as blood loss, anesthetic drugs and antihypertensives. Therefore, improved methods to monitor surgical nociception are clearly needed. In short, currently available nociceptive monitors measure unreliable indicators and predispose surgical patients to suboptimal opioid dosing administration leading to ineffective intraoperative control. The consequences for surgical patients can be significant, since increased postoperative pain and opioid requirements is associated with increased incidence of opioid dependency. This project proposes to develop a state-of-the-art sensors, algorithms, and prospective observational data to construct an integrated measure of nociceptive control based on autonomic (EDA) and neurophysiologic markers of arousal and nociception (EEG-based arousal and opioid signatures).
项目摘要 鉴于阿片类药物危机,尽量减少术后疼痛和术后阿片类药物需求,以减少 手术患者中的慢性阿片样物质依赖已经成为外科医生的主要关注点, 麻醉师有效的术中伤害控制可以减轻这些问题。不幸的是, 现有的伤害感受监测工具使用固有地易受术中影响的指示器。 监测这些指标往往导致次优的术中阿片类药物管理,因为没有办法, 为了说明这些测量是否受到伤害感受或许多其他术中 失血、麻醉药和降压药等因素。因此,改进监测方法 显然需要外科手术伤害感受。简而言之,目前可用的伤害性监测器测量不可靠 指标,使手术患者易于接受次优阿片类药物给药,导致无效 术中控制。手术患者的后果可能是显著的,因为术后增加 疼痛和阿片类药物需求与阿片类药物依赖发生率增加有关。这个项目 建议开发最先进的传感器,算法和前瞻性的观测数据,以构建一个 基于自主神经(EDA)和唤醒的神经生理学标志物的伤害性控制的综合测量 和伤害感受(基于EEG的唤醒和阿片类签名)。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Tuan Le Mau其他文献

Tuan Le Mau的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Tuan Le Mau', 18)}}的其他基金

Developing Active Stimulation and Monitoring Technologies to Optimize Pain and Nociception Management During Regional Anesthesia, General Anesthesia, and Post-Operative Care
开发主动刺激和监测技术,以优化区域麻醉、全身麻醉和术后护理期间的疼痛和伤害感受管理
  • 批准号:
    10604993
  • 财政年份:
    2023
  • 资助金额:
    $ 99.48万
  • 项目类别:
Developing a novel system combining cognitive assessment with PASCALL FDA-cleared intraoperative anesthesia EEG brain monitor to prevent postoperative neurocognitive disorders in aging patients
开发一种将认知评估与 FDA 批准的 PASCALL 术中麻醉脑电图脑监测仪相结合的新型系统,以预防老年患者术后神经认知障碍
  • 批准号:
    10760816
  • 财政年份:
    2023
  • 资助金额:
    $ 99.48万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10360566
  • 财政年份:
    2021
  • 资助金额:
    $ 99.48万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    10303200
  • 财政年份:
    2021
  • 资助金额:
    $ 99.48万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10157621
  • 财政年份:
    2020
  • 资助金额:
    $ 99.48万
  • 项目类别:
Personalized anesthetic brain monitoring: Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients
个性化麻醉大脑监测:为衰老、痴呆和阿尔茨海默病患者开发新型系统、传感器和算法
  • 批准号:
    9909360
  • 财政年份:
    2020
  • 资助金额:
    $ 99.48万
  • 项目类别:
Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements
开发新技术来监测手术和全身麻醉期间的伤害感受和阿片类药物的给药,以尽量减少术后阿片类药物的需求
  • 批准号:
    10654060
  • 财政年份:
    2020
  • 资助金额:
    $ 99.48万
  • 项目类别:

相似海外基金

Collaborative Research: Superinvaders: testing a general hypothesis of forest invasions by woody species across the Americas
合作研究:超级入侵者:测试美洲木本物种入侵森林的一般假设
  • 批准号:
    2331278
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Collaborative Research: Intertropical Convergence Zone Variations from Stable Oxygen Isotope Tree-ring Records in the Tropical Americas
合作研究:热带美洲稳定氧同位素树轮记录的热带辐合带变化
  • 批准号:
    2303525
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Collaborative Research: Superinvaders: testing a general hypothesis of forest invasions by woody species across the Americas
合作研究:超级入侵者:测试美洲木本物种入侵森林的一般假设
  • 批准号:
    2331277
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Collaborative Research: Intertropical Convergence Zone Variations from Stable Oxygen Isotope Tree-ring Records in the Tropical Americas
合作研究:热带美洲稳定氧同位素树轮记录的热带辐合带变化
  • 批准号:
    2303524
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Collaborative Research: Intertropical Convergence Zone Variations from Stable Oxygen Isotope Tree-ring Records in the Tropical Americas
合作研究:热带美洲稳定氧同位素树轮记录的热带辐合带变化
  • 批准号:
    2303526
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Collaborative Research: Superinvaders: testing a general hypothesis of forest invasions by woody species across the Americas
合作研究:超级入侵者:测试美洲木本物种入侵森林的一般假设
  • 批准号:
    2331276
  • 财政年份:
    2024
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
The Palestinian Americas: revolutionary struggle across the global south, 1950-1979
巴勒斯坦美洲:1950-1979 年全球南方的革命斗争
  • 批准号:
    AH/Y001214/1
  • 财政年份:
    2023
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Fellowship
Immuno-epidemiological Approach in Tackling Emerging & Re-emerging Infections in the Tropical Americas
应对新兴疾病的免疫流行病学方法
  • 批准号:
    22KK0279
  • 财政年份:
    2023
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
DISES: Coevolutionary dynamics of humans and maize in the Americas
疾病:美洲人类和玉米的共同进化动态
  • 批准号:
    2307175
  • 财政年份:
    2023
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
Conference: Reimagining Rights in the Americas
会议:重新构想美洲的权利
  • 批准号:
    2230329
  • 财政年份:
    2022
  • 资助金额:
    $ 99.48万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了