Methods for Fast and Efficient Oxygen Imaging

快速高效的氧气成像方法

• 批准号: 10698818
• 负责人: Mrignayani Kotecha
• 金额: $ 40万
• 依托单位: O2M TECHNOLOGIES, LLC
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10698818
• 关键词: 3-Dimensional; Acceleration; Acute; Animal Model; Attention; Clinic; Clinical; Complex; Computer software; Development; Electron Spin Resonance Spectroscopy; Environment; Evaluation; Fast Electron; Frequencies; Future; Goals; Hour; Human; Hypoxia; Image; Imaging Device; Inbred C3H Mice; Individual; Injury; Leg; Letters; Licensing; Machine Learning; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modeling; Myocardial Infarction; National Cancer Institute; Organ Transplantation; Oxygen; Pathway interactions; Performance; Perfusion; Periodicity; Phase; Physiologic pulse; Process; Radiation Dose Unit; Radiation therapy; Reporting; Resolution; Scientist; Speed; Stroke; System; Techniques; Technology; Testing; Time; Tissues; Tumor Biology; United States National Institutes of Health; Width; absorption; cancer imaging; cancer therapy; computerized data processing; deep learning; design; drug development; fibrosarcoma; image reconstruction; imager; imaging modality; imaging software; improved; in vivo; in vivo imaging; instrument; learning network; mouse model; pre-clinical; pressure; reconstruction; response; success; technology platform; therapy resistant; tool; tumor; tumor hypoxia

Abstract Intermittent or acute/cyclic hypoxia in tumors, with frequencies between a few cycles per minute to hours, is receiving increased attention because this type of hypoxia has been reported to have an influence on tumor malignancy as well as treatment resistance via increased expression of pro-survival pathways. Fast oxygen imaging methods are needed for the measurement of acute tumor hypoxia. Pulse electron paramagnetic resonance imaging (pEPRI) is a promising tool to provide three-dimensional partial oxygen pressure (pO2) maps in live tissues and tumors to assist with advanced studies of tumor biology, perfusion, drug development, and radiation treatment. Single point imaging (SPI), an acquisition technique developed at National Cancer Institute (NCI), is a subset of pEPRI methods that can be used for oxygen image acquisition. It provides high-resolution, high-fidelity images but is slow due to the need for acquiring each k-space point individually. In the current project, our goal is to improve the image acquisition speed of SPI by utilizing a combination of advanced hardware and deep learning. This will improve the imaging speed by many folds without compromising the image quality. These advances will be tested in a mouse model of fibrosarcoma tumor. This project will bring an NIH-developed technology to the commercial level. Our long-term goal is to imply the advanced hardware and software technologies of oxygen imaging to clinics to assist with oxygen-guided tumor treatments.

摘要 肿瘤中的间歇性或急性/周期性缺氧，频率在每分钟几个周期到几个小时之间， 由于据报道这种类型的缺氧对肿瘤有影响，因此受到越来越多的关注 恶性肿瘤以及通过增加促存活途径的表达的治疗抗性。快氧 需要成像方法来测量急性肿瘤缺氧。脉冲电子顺磁 共振成像（pEPRI）是一种提供三维氧分压（pO 2）图的有前途的工具 在肝组织和肿瘤中，以协助肿瘤生物学、灌注、药物开发和 放射治疗单点成像（SPI），一种由美国国家癌症研究所开发的采集技术 (NCI)是可用于氧图像采集的pEPRI方法的子集。它提供高分辨率， 高保真度图像，但由于需要单独采集每个k空间点而速度较慢。在当前 项目，我们的目标是提高图像采集速度的SPI通过利用先进的组合， 硬件和深度学习。这将提高成像速度许多倍，而不影响 图像质量这些进展将在纤维肉瘤肿瘤的小鼠模型中进行测试。该项目将带来一个 NIH开发的技术达到商业水平。我们的长期目标是实现先进的硬件和 氧气成像软件技术应用于临床，以协助氧气引导的肿瘤治疗。