Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias
Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias
批准号:
10698169
负责人:
JOSHUA T DUBNAU
金额:
$77.91万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-15 至 2027-06-30
关键词:
AgeAgingAllelesAlzheimer&aposs DiseaseAlzheimer&aposs disease patientAlzheimer&aposs disease related dementiaAmyotrophic Lateral SclerosisAstrocytesBrainCell Culture TechniquesCell DeathCellsClinicalCultured CellsDNA DamageDataDiagnosisDiseaseDisease ProgressionDrosophila genusElementsEndogenous RetrovirusesExhibitsFaceFeedbackFrontotemporal DementiaFunctional disorderGenesGenomeHumanInfectionInterventionLiteratureMammalian CellMediatorModelingMovementNerve DegenerationNeurodegenerative DisordersNeurogliaNeuronsOnset of illnessOutcomePathologyPatientsPharmaceutical PreparationsPhysiologicalPlayPublicationsRNA SequencesReporterRetrotransposonRetroviridaeRiskRoleSiteSystemTDP-43 aggregationTestingTissuesVirusWorkage relatedclinically relevantdesignexperimental studyflyfrontotemporal lobar dementia amyotrophic lateral sclerosishuman subjectin vivoinsightknock-downneuralnovelperineuralprotein TDP-43protein aggregationproteostasisstemsuccesstransmission process
中文摘要
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英文摘要
PROJECT ABSTRACT
This proposal investigates a novel idea to explain how TDP-43 protein pathology is
amplified and spread between glia and neurons after initiation of disease. TDP-43
aggregation pathology is a core feature of a suite of neurodegenerative disorders
including frontotemporal dementia, Alzheimer’s and amyotrophic lateral sclerosis. We
propose and will test the hypothesis that retrotransposons and endogenous retroviruses
are both activated by TDP-43 pathology and can be upstream initiators of such
pathology. We also will test the idea that these mobile elements contribute a mechanism
of inter-cellular spread that could underlie progression of disease. We will use both
Drosophila models and mammalian cell culture to test the core features of this proposed
model.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retroviruses
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批准号:10416198
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项目类别:
-
资助金额:$179.79万
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财政年份:2022
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负责人:JOSHUA T DUBNAU
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依托单位:
Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias
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批准号:10516288
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项目类别:
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资助金额:$70.57万
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财政年份:2022
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负责人:JOSHUA T DUBNAU
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依托单位:
A systems approach to uncover upstream activators and common downstream pathways of neurodegeneration in a Drosophila model
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批准号:9414143
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项目类别:
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资助金额:$358.88万
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财政年份:2017
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负责人:JOSHUA T DUBNAU
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依托单位:
The role of the dNPF brain circuit in coding food odor value
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批准号:9199222
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项目类别:
-
资助金额:$33.68万
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财政年份:2016
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负责人:JOSHUA T DUBNAU
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依托单位:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
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批准号:9177772
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项目类别:
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资助金额:$34.53万
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财政年份:2016
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负责人:JOSHUA T DUBNAU
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依托单位:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
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批准号:9001385
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项目类别:
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资助金额:$32.23万
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财政年份:2015
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负责人:JOSHUA T DUBNAU
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依托单位:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
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批准号:8864739
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项目类别:
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资助金额:$42.0万
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财政年份:2015
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负责人:JOSHUA T DUBNAU
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依托单位:
The role of the dNPF brain circuit in coding food odor value
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批准号:8788348
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项目类别:
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资助金额:$40.39万
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财政年份:2014
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负责人:JOSHUA T DUBNAU
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依托单位:
Genome-wide regulatory network governing neuronal mRNA translation.
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批准号:8130734
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项目类别:
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资助金额:$43.07万
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财政年份:2009
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负责人:JOSHUA T DUBNAU
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依托单位:
Genome-wide regulatory network governing neuronal mRNA translation.
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批准号:8318219
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项目类别:
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资助金额:$46.61万
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财政年份:2009
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负责人:JOSHUA T DUBNAU
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依托单位:
Genome-wide regulatory network governing neuronal mRNA translation.
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批准号:8533035
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项目类别:
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资助金额:$45.37万
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财政年份:2009
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负责人:JOSHUA T DUBNAU
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依托单位:
Genome-wide regulatory network governing neuronal mRNA translation.
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批准号:7764325
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项目类别:
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资助金额:$43.17万
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财政年份:2009
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负责人:JOSHUA T DUBNAU
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依托单位:
Functional Anatomy of Learning and Memory in Drosophila
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批准号:7454489
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项目类别:
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资助金额:$34.68万
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财政年份:2004
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负责人:JOSHUA T DUBNAU
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依托单位:
Functional Anatomy of Learning and Memory in Drosophila
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批准号:6949133
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项目类别:
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资助金额:$36.57万
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财政年份:2004
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负责人:JOSHUA T DUBNAU
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依托单位:
Functional Anatomy of Learning and Memory in Drosophila
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批准号:7102642
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项目类别:
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资助金额:$35.71万
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财政年份:2004
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负责人:JOSHUA T DUBNAU
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依托单位:
Functional Anatomy of Learning and Memory in Drosophila
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批准号:7286372
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项目类别:
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资助金额:$34.68万
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财政年份:2004
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负责人:JOSHUA T DUBNAU
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依托单位:
Functional Anatomy of Learning and Memory in Drosophila
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批准号:6823396
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项目类别:
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资助金额:$34.98万
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财政年份:2004
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负责人:JOSHUA T DUBNAU
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依托单位:
DIFFERENTIAL PCR SCREEN FOR LONG TERM MEMORY
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批准号:2673383
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项目类别:
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资助金额:$2.86万
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财政年份:1998
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负责人:JOSHUA T DUBNAU
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依托单位:
DIFFERENTIAL PCR SCREEN FOR LONG TERM MEMORY
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批准号:2403029
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项目类别:
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资助金额:$2.44万
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财政年份:1997
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负责人:JOSHUA T DUBNAU
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依托单位:
DIFFERENTIAL PCR SCREEN FOR LONG TERM MEMORY
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批准号:2196517
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项目类别:
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资助金额:$2.26万
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财政年份:1996
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负责人:JOSHUA T DUBNAU
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依托单位:
海外基金