Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias
阿尔茨海默病相关痴呆中逆转录转座子/内源性逆转录病毒和 TDP-43 之间的反馈放大
基本信息
- 批准号:10516288
- 负责人:
- 金额:$ 70.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-15 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AgeAgingAllelesAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmyotrophic Lateral SclerosisAstrocytesBrainCell Culture TechniquesCell DeathCellsClinicalCultured CellsDNA DamageDataDiagnosisDiseaseDisease ProgressionDrosophila genusElementsEndogenous RetrovirusesExhibitsFaceFeedbackFrontotemporal DementiaFunctional disorderGenesGenomeHumanInfectionInterventionLiteratureMammalian CellMediator of activation proteinModelingMovementNerve DegenerationNeurodegenerative DisordersNeurogliaNeuronsOnset of illnessOutcomePathologyPatientsPharmaceutical PreparationsPhysiologicalPlayPublicationsRNA SequencesReporterRetrotransposonRetroviridaeRiskRoleSiteSystemTDP-43 aggregationTestingTissuesVirusWorkage relatedclinically relevantdesignexperimental studyflyfrontotemporal lobar dementia-amyotrophic lateral sclerosishuman subjectin vivoinsightknock-downnovelperineuralprotein TDP-43protein aggregationproteostasisrelating to nervous systemstemsuccesstransmission process
项目摘要
PROJECT ABSTRACT
This proposal investigates a novel idea to explain how TDP-43 protein pathology is
amplified and spread between glia and neurons after initiation of disease. TDP-43
aggregation pathology is a core feature of a suite of neurodegenerative disorders
including frontotemporal dementia, Alzheimer’s and amyotrophic lateral sclerosis. We
propose and will test the hypothesis that retrotransposons and endogenous retroviruses
are both activated by TDP-43 pathology and can be upstream initiators of such
pathology. We also will test the idea that these mobile elements contribute a mechanism
of inter-cellular spread that could underlie progression of disease. We will use both
Drosophila models and mammalian cell culture to test the core features of this proposed
model.
项目摘要
这项提案调查了一种新的想法来解释TDP-43蛋白病理是如何
疾病开始后,在神经胶质细胞和神经元之间扩增和扩散。TDP-43
聚集病理是一组神经退行性疾病的核心特征
包括额颞叶痴呆、阿尔茨海默氏症和肌萎缩侧索硬化症。我们
提出并将检验反转录转座子和内源性逆转录病毒的假设
都是由TDP-43病理激活的,都可以是这种
病理学。我们还将测试这些移动元素有助于机制的想法
细胞间传播可能是疾病发展的基础。我们将使用这两种方法
果蝇模型和哺乳动物细胞培养的核心特征测试这一建议
模特。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOSHUA T DUBNAU其他文献
JOSHUA T DUBNAU的其他文献
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{{ truncateString('JOSHUA T DUBNAU', 18)}}的其他基金
Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retroviruses
大脑衰老和阿尔茨海默氏症相关痴呆:逆转录转座子和内源性逆转录病毒的融合
- 批准号:
10416198 - 财政年份:2022
- 资助金额:
$ 70.57万 - 项目类别:
Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementias
阿尔茨海默病相关痴呆中逆转录转座子/内源性逆转录病毒和 TDP-43 之间的反馈放大
- 批准号:
10698169 - 财政年份:2022
- 资助金额:
$ 70.57万 - 项目类别:
A systems approach to uncover upstream activators and common downstream pathways of neurodegeneration in a Drosophila model
揭示果蝇模型中神经变性的上游激活剂和常见下游途径的系统方法
- 批准号:
9414143 - 财政年份:2017
- 资助金额:
$ 70.57万 - 项目类别:
The role of the dNPF brain circuit in coding food odor value
dNPF 脑回路在编码食物气味值中的作用
- 批准号:
9199222 - 财政年份:2016
- 资助金额:
$ 70.57万 - 项目类别:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
TDP-43 介导的神经变性中基于 siRNA 的基因沉默和逆转录转座子激活的丧失
- 批准号:
9177772 - 财政年份:2016
- 资助金额:
$ 70.57万 - 项目类别:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
TDP-43 介导的神经变性中基于 siRNA 的基因沉默和逆转录转座子激活的丧失
- 批准号:
9001385 - 财政年份:2015
- 资助金额:
$ 70.57万 - 项目类别:
Loss of siRNA based gene silencing and retrotransposon activation in TDP-43 mediated neurodegeneration
TDP-43 介导的神经变性中基于 siRNA 的基因沉默和逆转录转座子激活的丧失
- 批准号:
8864739 - 财政年份:2015
- 资助金额:
$ 70.57万 - 项目类别:
The role of the dNPF brain circuit in coding food odor value
dNPF 脑回路在编码食物气味值中的作用
- 批准号:
8788348 - 财政年份:2014
- 资助金额:
$ 70.57万 - 项目类别:
Genome-wide regulatory network governing neuronal mRNA translation.
控制神经元 mRNA 翻译的全基因组调控网络。
- 批准号:
8130734 - 财政年份:2009
- 资助金额:
$ 70.57万 - 项目类别:
Genome-wide regulatory network governing neuronal mRNA translation.
控制神经元 mRNA 翻译的全基因组调控网络。
- 批准号:
8318219 - 财政年份:2009
- 资助金额:
$ 70.57万 - 项目类别:
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