Administrative Core

项目概要-行政核心 这一对抗抗生素耐药性细菌（CARB）的建议概述了一个 多学科合作伙伴关系，采用新的和创新的方法， 细菌被膜组装的潜在机制，并能够发现针对多药耐药的治疗方法。 耐药性感染因为这是一项学术努力，重点将放在发展科学知识上。 这将允许发现新的化合物和蛋白质疗法， 涉及细胞包膜生物发生的靶点，膜蛋白和蛋白复合物是所有研究的焦点。 三个项目。该项目团队由一群有成就的科学家组成， 生物化学方面的专业知识，包括多酶途径和大型蛋白质机器的重建， 膜蛋白和膜蛋白复合物的结构生物学， 细胞被膜生物发生所必需的成分，创造性地使用遗传筛选来解剖细胞被膜， 调节在细胞分裂和包膜生物发生中重要的途径，以及在新的 用于发现抗微生物化合物和治疗性蛋白质的技术和筛选方法。 在革兰氏阴性和革兰氏阳性细胞包膜的协同专业知识也很好地代表 在项目团队成员中。项目小组的科学专门知识将得到以下方面的补充： 丰富的行政经验。因此，CARB行政核心的目标是监督 顺利推行研究计划和调配资源，并培养凝聚力和良好的 整体运作，以实现大于单个项目总和的目标。这将是 通过实现以下具体目标来完成：1）提供项目管理，监督， 合规保证，2）促进CARB调查人员和来自不同领域的受训人员之间的定期互动 实验室和项目以平稳和有效的方式，并促进与其他哈佛范围内的举措的连接; 3)为该计划的财务管理提供关键基础设施; 4）提供单一联系点， 积极协调与NIAID、项目官员和其他NIAID工作人员的持续沟通， 举措行政核心将促进继续发展一个高度运作、高度一体化、 和协同的整体，以促进急需的科学进步，在一个具有挑战性的研究领域， 在产生资源和促进数据的同时， 与更大的科学界分享。

PROJECT SUMMARY – Administrative Core This Combating Antibiotic Resistant Bacteria (CARB) proposal outlines the design and function of a multidisciplinary, collaborative partnership applying new and innovative approaches to understand the mechanisms underlying bacterial envelope assembly and enable the discovery of treatments against multidrug- resistant infections. Because this is an academic effort, emphasis will be on developing the scientific knowledge that will allow discovery of new compounds and protein therapeutics for especially challenging and unexploited targets involved in cell envelope biogenesis, with membrane proteins and protein complexes a focal point in all three projects. The project team comprises an accomplished group of scientists with extensive and synergistic expertise in biochemistry, including reconstitutions of multi-enzyme pathways and large protein machines, in structural biology of membrane proteins and membrane protein complexes, in approaches for discovery of components essential for cell envelope biogenesis, in the creative use of genetic screens to dissect the regulation of pathways important in cell division and envelope biogenesis, and in development of new technologies and screening approaches for discovery of antimicrobial compounds and therapeutic proteins. Synergistic expertise in both the Gram-negative and Gram-positive cell envelopes is also well-represented among the project team members. The scientific expertise of the project team will be complemented by substantial administrative experience. The goal of the CARB Administrative Core therefore is to oversee the smooth implementation of the research plan and deployment of resources, and to foster the cohesive and well- functioning whole to achieve goals that are greater than the sum of the individual projects. This will be accomplished by achieving the following Specific Aims: 1) Provide program management, oversight, and compliance assurance, 2) Facilitate regular interactions among CARB investigators and trainees from the various labs and projects in a smooth and effective manner, and promote connectivity with other Harvard-wide initiatives; 3) Provide critical infrastructure for fiscal management of the program; 4) Provide a single point of contact and active coordination for on-going communication with NIAID, the Program Officer, and other NIAID staff and initiatives. The Administrative Core will foster the continued development of a highly functioning, well integrated, and synergistic whole to contribute to much-needed scientific advances in a challenging area of research that holds considerable promise for overcoming antibiotic resistance, while generating resources and fostering data sharing with the greater scientific community.