Administrative Core

项目摘要--行政核心 这份抗击抗生素耐药细菌(CARB)的提案概述了一种 多学科、协作伙伴关系应用新的创新方法来理解 细菌包膜组装的潜在机制，并使发现治疗多药- 抵抗力感染。由于这是一项学术努力，因此重点将放在发展科学知识上 这将允许发现新的化合物和蛋白质疗法，特别是具有挑战性的和未开发的 参与细胞被膜生物发生的靶点，膜蛋白和蛋白复合体是ALL的焦点 三个项目。项目团队由一群成就卓著的科学家组成，具有广泛的协作性。 在生物化学方面的专业知识，包括重组多酶途径和大型蛋白质机器，在 膜蛋白和膜蛋白复合体的结构生物学 在创造性地使用遗传筛选来解剖细胞包膜生物发生所必需的组件 调控在细胞分裂和包膜生物发生以及新细胞发育中的重要途径 发现抗微生物化合物和治疗性蛋白质的技术和筛选方法。 在革兰氏阴性和革兰氏阳性细胞包膜方面的协同专业知识也得到了很好的代表 在项目团队成员中。项目团队的科学专长将得到以下补充 有丰富的行政经验。因此，CARB行政核心的目标是监督 顺利实施科研计划和资源配置，促进科研工作凝聚力强、效益好。 整体运作，以实现大于单个项目总和的目标。这将是 通过实现以下具体目标来实现：1)提供计划管理、监督和 合规保证，2)促进CARB调查人员和来自不同领域的受训人员之间的定期互动 实验室和项目顺利有效，促进与哈佛其他倡议的互联互通； 3)为计划的财务管理提供关键基础设施；4)提供单点联系和 积极协调与NIAID、项目官员和其他NIAID工作人员的持续沟通 首创精神。行政核心将促进一个高度运作、整合良好、 和协同作用的整体，为这一具有挑战性的研究领域中亟需的科学进步做出贡献 在克服抗生素耐药性方面有相当大的希望，同时生成资源和促进数据 与更大的科学界分享。

PROJECT SUMMARY – Administrative Core This Combating Antibiotic Resistant Bacteria (CARB) proposal outlines the design and function of a multidisciplinary, collaborative partnership applying new and innovative approaches to understand the mechanisms underlying bacterial envelope assembly and enable the discovery of treatments against multidrug- resistant infections. Because this is an academic effort, emphasis will be on developing the scientific knowledge that will allow discovery of new compounds and protein therapeutics for especially challenging and unexploited targets involved in cell envelope biogenesis, with membrane proteins and protein complexes a focal point in all three projects. The project team comprises an accomplished group of scientists with extensive and synergistic expertise in biochemistry, including reconstitutions of multi-enzyme pathways and large protein machines, in structural biology of membrane proteins and membrane protein complexes, in approaches for discovery of components essential for cell envelope biogenesis, in the creative use of genetic screens to dissect the regulation of pathways important in cell division and envelope biogenesis, and in development of new technologies and screening approaches for discovery of antimicrobial compounds and therapeutic proteins. Synergistic expertise in both the Gram-negative and Gram-positive cell envelopes is also well-represented among the project team members. The scientific expertise of the project team will be complemented by substantial administrative experience. The goal of the CARB Administrative Core therefore is to oversee the smooth implementation of the research plan and deployment of resources, and to foster the cohesive and well- functioning whole to achieve goals that are greater than the sum of the individual projects. This will be accomplished by achieving the following Specific Aims: 1) Provide program management, oversight, and compliance assurance, 2) Facilitate regular interactions among CARB investigators and trainees from the various labs and projects in a smooth and effective manner, and promote connectivity with other Harvard-wide initiatives; 3) Provide critical infrastructure for fiscal management of the program; 4) Provide a single point of contact and active coordination for on-going communication with NIAID, the Program Officer, and other NIAID staff and initiatives. The Administrative Core will foster the continued development of a highly functioning, well integrated, and synergistic whole to contribute to much-needed scientific advances in a challenging area of research that holds considerable promise for overcoming antibiotic resistance, while generating resources and fostering data sharing with the greater scientific community.