Research Experience & Training Core

摘要 耶鲁大学超级基金研究和培训计划（YSRTP）将培养以问题为基础，以解决方案为导向的 与水污染物归宿、暴露、补救和不良健康影响主题相关的研究。到 为了最有效，这一奋进需要交叉训练的科学家，工程师和生物医学研究人员， 广泛的沟通技巧，以成功地解决新出现的研究和健康问题。的 拟议的YSRTP联合了公共卫生，医学，遗传学，环境化学，环境 以及化学归宿和迁移。我们将利用这种学科多样性，部门和 大学资源，以及YSRTP的多样化研究领域和核心，以培养学员在他们的 专业领域，以及在环境卫生，化学， 和工程;对控制接触危险环境化学品很重要的学科。 YSRTP研究经验培训协调核心（RETCC）的目标是扩大 教育，研究和专业发展的机会，前和博士后学员。四 提出了具体目标。1.招募一批多样化的、有学术准备的博士生和博士后干部， 博士研究员; 2.通过跨学科的要求提供跨学科的培训 社区外展、成果传播、风险沟通方面的课程和重点培训， 研究翻译; 3.设计和实施跨学科研究交流计划， 耶鲁大学; 4。通过有计划的互动，鼓励受训人员的专业发展， 社区合作伙伴、政府机构和私营企业。RETCC的核心活动将包括具体的 研讨会和讲习班，以扩大学员的教育和研究技能，导师计划，以准备 学生的候选人资格考试和监测论文的进展;研究生研究研讨会和其他 开展辅助活动，鼓励受训人员之间的互动，建立学术社区， 评估过程，以不断更新和改进RETCC。培训将利用更广泛的耶鲁大学 大学教学，研究和指导基础设施，并与YSRTP核心建立协同作用， 管理（研究翻译），社区参与和数据管理和分析。 该培训核心将侧重于在化学、环境和生物技术领域工作的博士前和博士后学员。 工程，公共卫生和生物医学研究在YSRTP，包括一个跨学科的 （环境工程和生物医学研究）董事职位。具体研究领域包括： 水污染物对生殖毒理学的影响，1，4-二氧六环（1.4-DX）暴露和早期 饮用水中的生物学效应，识别早期与晚期1，4-DX诱导的肝损伤， 致癌作用和潜在的生物标志物的暴露，生物传感器和化学传感器和在线 污染物监测、下一代模块化高级氧化工艺技术的开发。

ABSTRACT The Yale Superfund Research and Training Program (YSRTP) will foster problem-based, solution-oriented research related to the theme of water contaminant fate, exposure, remediation, and adverse health effects. To be most effective, this endeavor requires cross-trained scientists, engineers, and biomedical researchers with wide-ranging communication skills to successfully address emerging research and health questions. The proposed YSRTP unites the fields of public health, medicine, genetics, environmental chemistry, environmental engineering, and chemical fate and transport. We will leverage this disciplinary diversity, departmental and University resources, and YSRTP’s diverse research areas and cores to produce trainees with depth in their specialized field, and a breadth of knowledge and professional experiences in environmental health, chemistry, and engineering; disciplines that are important for controlling exposure to hazardous environmental chemicals. The goal of the YSRTP Research Experience Training Coordination Core (RETCC) is to expand the breadth of educational, research, and professional development opportunities to pre- and post-doctoral trainees. Four specific aims are proposed. 1. Recruit a cadre of diverse, academically prepared doctoral students and post- doctoral researchers; 2. Provide interdisciplinary training through a requirement of cross-disciplinary coursework and focused training in community outreach, results dissemination, risk communication, and research translation; 3. Design and implement a program for interdisciplinary research exchanges within and external to Yale; and 4. Encourage trainee professional development through planned interactions with community partners, government agencies, and private industry. RETCC central activities will include specific symposia and workshops to broaden trainee education and research skillsets, mentorship programs to prepare students for candidacy exams and monitor dissertation progress; a graduate research seminar and other ancillary activities to encourage interaction among trainees and build a scholastic community, and an evaluation process to continually update and improve the RETCC. Training will leverage the broader Yale University teaching, research, and mentoring infrastructure and build synergies with the YSRTP cores in administration (research translation), community engagement and data management and analytics. This training core will focus on pre- and post-doctoral trainees working in the fields of chemistry, environmental engineering, public health, and biomedical research within the YSRTP and includes an interdisciplinary (environmental engineering and biomedical research) directorship. Specific research areas include: the effects of water contaminants on reproductive toxicology, evaluation of 1,4-Dioxane (1.4-DX) exposure and early biological effects in drinking water, identification of early vs. late 1,4-DX-induced liver damage and carcinogenesis and of potential biomarkers of exposure, biosensors and chemical sensors and online contaminant monitoring, development of next-generation, modular advanced oxidation process technology.