Research Experience & Training Core

摘要 耶鲁大学超级基金研究和培训计划(YSRTP)将促进以问题为基础、以解决方案为导向 与水污染物的去向、暴露、补救和有害健康影响等主题相关的研究。至 要想达到最有效的效果，这项工作需要经过交叉培训的科学家、工程师和生物医学研究人员 广泛的沟通技巧，成功解决新出现的研究和健康问题。这个 提出的YSRTP将公共卫生、医学、遗传学、环境化学、环境 工程学、化学命运和运输。我们将利用这种学科多样性、部门和 大学资源，以及YSRTP的不同研究领域和核心，以培养在其 专业领域，以及在环境健康、化学、 和工程学；对控制接触危险环境化学品很重要的学科。 YSRTP研究体验培训协调核心(RETCC)的目标是扩大 为博士后和博士后实习生提供教育、研究和专业发展机会。四 提出了具体的目标。1.招募一支多样化、有学术准备的博士生和博士后干部队伍。 博士生研究人员；2.通过跨学科要求提供跨学科培训 社区推广、成果传播、风险沟通和重点培训的课程工作和重点培训 研究翻译；3.设计和实施跨学科研究交流计划 耶鲁之外；以及4.通过有计划的互动，鼓励实习生的职业发展 社区合作伙伴、政府机构和私营企业。RETCC中心活动将包括具体的 举办研讨会和讲习班，以扩大学员的教育和研究技能，并为指导方案做准备 学生参加候选人资格考试并监督论文进度；研究生研究研讨会等 辅助活动，以鼓励学员之间的互动和建立学术社区，以及 评估过程，以不断更新和改进RETCC。培训将利用更广泛的耶鲁 大学教学、研究和指导基础设施，并与YSRTP核心在 管理(研究翻译)、社区参与以及数据管理和分析。 这一培训的核心将集中在化学、环境等领域的博士后和博士后培训人员 YSRTP内的工程、公共卫生和生物医学研究，并包括一个跨学科的 (环境工程和生物医学研究)董事职务。具体研究领域包括：影响 水污染物对生殖毒理学的影响、1，4-二恶烷(1.4-DX)暴露的评估和早期 饮用水中的生物效应，早期和晚期1，4-DX引起的肝损伤的鉴定和 致癌和潜在的暴露生物标记物、生物传感器和化学传感器以及在线 污染物监测，下一代模块化高级氧化工艺技术的开发。

ABSTRACT The Yale Superfund Research and Training Program (YSRTP) will foster problem-based, solution-oriented research related to the theme of water contaminant fate, exposure, remediation, and adverse health effects. To be most effective, this endeavor requires cross-trained scientists, engineers, and biomedical researchers with wide-ranging communication skills to successfully address emerging research and health questions. The proposed YSRTP unites the fields of public health, medicine, genetics, environmental chemistry, environmental engineering, and chemical fate and transport. We will leverage this disciplinary diversity, departmental and University resources, and YSRTP’s diverse research areas and cores to produce trainees with depth in their specialized field, and a breadth of knowledge and professional experiences in environmental health, chemistry, and engineering; disciplines that are important for controlling exposure to hazardous environmental chemicals. The goal of the YSRTP Research Experience Training Coordination Core (RETCC) is to expand the breadth of educational, research, and professional development opportunities to pre- and post-doctoral trainees. Four specific aims are proposed. 1. Recruit a cadre of diverse, academically prepared doctoral students and post- doctoral researchers; 2. Provide interdisciplinary training through a requirement of cross-disciplinary coursework and focused training in community outreach, results dissemination, risk communication, and research translation; 3. Design and implement a program for interdisciplinary research exchanges within and external to Yale; and 4. Encourage trainee professional development through planned interactions with community partners, government agencies, and private industry. RETCC central activities will include specific symposia and workshops to broaden trainee education and research skillsets, mentorship programs to prepare students for candidacy exams and monitor dissertation progress; a graduate research seminar and other ancillary activities to encourage interaction among trainees and build a scholastic community, and an evaluation process to continually update and improve the RETCC. Training will leverage the broader Yale University teaching, research, and mentoring infrastructure and build synergies with the YSRTP cores in administration (research translation), community engagement and data management and analytics. This training core will focus on pre- and post-doctoral trainees working in the fields of chemistry, environmental engineering, public health, and biomedical research within the YSRTP and includes an interdisciplinary (environmental engineering and biomedical research) directorship. Specific research areas include: the effects of water contaminants on reproductive toxicology, evaluation of 1,4-Dioxane (1.4-DX) exposure and early biological effects in drinking water, identification of early vs. late 1,4-DX-induced liver damage and carcinogenesis and of potential biomarkers of exposure, biosensors and chemical sensors and online contaminant monitoring, development of next-generation, modular advanced oxidation process technology.