Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Admin Core

免疫、微生物群、代谢组学和临床表型的拓扑图揭示 ME/CFS 疾病机制 - Admin Core

• 批准号: 10664153
• 负责人: Derya Unutmaz
• 金额: $ 4.54万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664153
• 关键词: Acquired Immunodeficiency Syndrome; Administrator; Advocate; Chronic Fatigue Syndrome; Clinical; Collaborations; Communication; Communities; Community Outreach; Congresses; Connecticut; Data; Disease; Education; Education and Outreach; Educational Activities; Ensure; Feedback; Fostering; General Population; Geographic Distribution; Goals; Immune; Immunologist; Leadership; Location; Logistics; Monitor; North Carolina; Occupational activity of managing finances; Office of Administrative Management; Patient Monitoring; Patient Recruitments; Patients; Personnel Management; Physicians; Preparation; Production; Protocols documentation; Publications; Research; Research Activity; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Running; Series; Source; Strategic Planning; Technology; Time; United States National Institutes of Health; Universities; Videoconferencing; career development; clinical phenotype; conflict resolution; data management; data sharing; experience; medical schools; meetings; member; metabolomics; microbiota; podcast; programs; virtual; webinar

PROJECT SUMMARY ADMINISTRATIVE CORE The goal of the Administrative (Admin) Core is to provide management, oversight and logistical support for the proposed JAX Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center (ME/CFS CRC). The Admin Core's role will be to: 1) foster productive scientific interactions within the JAX ME/CFS CRC, which involves 12 investigators at four different locations (JAX, University of Connecticut, North Carolina State University, Bateman Horne Center); 2) maintain alignment of the JAX ME/CFS CRC with ME/CFS Network activities; 3) monitor the progress of research projects, collaborative projects, and cores towards their specific research and resource-sharing goals; 4) ensure efficient data sharing with the ME/CFS Data Management and Coordinating Center (DMCC); 5) coordinate career development and community outreach activities; and 6) administer the solicitation, review, and selection of Collaborative Project proposals. The Admin Core will be led by Center Director Dr. Derya Unutmaz, a highly accomplished immunologist with experience in Center leadership and a deep connection to the ME/CFS community. Dr. Unutmaz recently formed a clinical alliance withthe Bateman Horne Center of Excellence, the clinical partner on this application, to study ME/CFS. Dr. Unutmaz will leverage this connection with the BHC and with the proposed Community Impact Steering Committee as a source of feedback from key stakeholders as well as an outlet for dissemination of ME/CFS research. The Admin Core will leverage the excellent capabilities, facilities and resources offered at JAX for administering large-scale collaborative research projects and educational activities. These resources include support for a full time, institutionally supported Center Administrator, who will assist Dr. Unutmaz by performing many essential Center functions. Together, Dr. Unutmaz and the Center Administrator will effectively execute the following Specific Aims: 1) Optimize integration and function of JAX ME/CFS CRC activities through strong administrative and scientific oversight, including strategic planning, budgetary oversight, conflict resolution, executive decisions on the direction of research activities and collaborations with other ME/CFS Centers; 2) Enhance communication and collaboration among JAX ME/CFS CRC investigators and between ME/CFS centers and NIH representatives; and 3) Convene Community Impact Steering Committee and engage in education and outreach activities for ME/CFS patients, physicians, and investigators new to ME/CFS research.

项目摘要 行政（Admin）核心的目标是提供管理、监督和后勤支助， 拟议中的JAX肌痛性脑脊髓炎/慢性疲劳综合征合作研究中心 (ME/CFS CRC）。管理核心的作用是：1）促进JAX内富有成效的科学交互 ME/CFS CRC，涉及四个不同地点的12名研究人员（JAX，康涅狄格大学， 北卡罗来纳州州立大学，贝特曼霍恩中心）; 2）保持JAX ME/CFS CRC的一致性 与ME/CFS网络活动; 3）监测研究项目，合作项目的进展， （4）确保与各核心组织的有效数据共享;（5）确保与各核心组织的有效数据共享。 ME/CFS数据管理和协调中心（DMCC）; 5）协调职业发展， 社区外展活动;以及6）管理协作的征集，审查和选择 项目提案。管理核心将由中心主任Derya Unutmaz博士领导，他是一位非常有成就的 具有中心领导经验的免疫学家，与ME/CFS社区有着深厚的联系。博士 Unutmaz最近与临床合作伙伴Bateman Horne Center of Excellence建立了临床联盟 研究ME/CFS。Unutmaz博士将利用这种与BHC和 拟议的社区影响指导委员会作为主要利益相关者的反馈来源， 传播教育部/爱幼学校研究成果的渠道。 管理核心将 利用优秀的能力、设施 JAX为管理大规模的合作研究项目和教育项目提供的资源 活动这些资源包括对全职的、机构支持的中心管理员的支持， 协助Unutmaz博士执行许多重要的中心职能。 在一起， 博士Unutmaz和中心 管理员将有效地执行以下具体目标：1）优化JAX的集成和功能 通过强有力的行政和科学监督，包括战略规划， 预算监督、冲突解决、关于研究活动方向的行政决定， 与其他ME/CFS中心的合作; 2）加强JAX ME/CFS之间的沟通和协作 CRC研究者和ME/CFS中心与NIH代表之间的沟通;以及3）召集社区影响 指导委员会，并参与ME/CFS患者，医生和 新的ME/CFS研究人员。