Topological Mapping of Immune, Microbiota, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms - Admin Core

项目概要 行政核心 行政（Admin）核心的目标是为以下部门提供管理、监督和后勤支持： 拟议的 JAX 肌痛性脑脊髓炎/慢性疲劳综合症合作研究中心 （ME/CFS CRC）。管理核心的作用是：1）促进 JAX 内富有成效的科学互动 ME/CFS CRC，涉及四个不同地点（JAX、康涅狄格大学、 北卡罗来纳州立大学贝特曼霍恩中心）； 2) 保持 JAX ME/CFS CRC 的对齐 与 ME/CFS 网络活动； 3）监控研究项目、合作项目的进展，以及 实现具体研究和资源共享目标的核心； 4）确保与数据的高效共享 ME/CFS 数据管理和协调中心 (DMCC)； 5）协调职业发展 社区外展活动； 6) 管理协作者的征集、审查和选择 项目建议。管理核心将由中心主任 Derya Unutmaz 博士领导，他是一位卓有成就的人 免疫学家，具有中心领导经验并与 ME/CFS 社区有深厚的联系。博士。 Unutmaz 最近与临床合作伙伴 Bateman Horne Center of Excellence 建立了临床联盟 在此应用程序上，研究 ME/CFS。 Unutmaz 博士将利用与 BHC 和 拟议的社区影响指导委员会作为主要利益相关者以及社区影响反馈的来源 ME/CFS 研究传播的渠道。 管理核心将 利用卓越的能力、设施 JAX 提供的用于管理大型合作研究项目和教育的资源 活动。这些资源包括对全职、有机构支持的中心管理员的支持，他将 协助 Unutmaz 博士履行中心的许多重要职能。 在一起， Unutmaz 博士和中心 管理员将有效执行以下具体目标： 1) 优化 JAX 的集成和功能 ME/CFS CRC 活动通过强有力的行政和科学监督，包括战略规划、 预算监督、冲突解决、关于研究活动方向的行政决定以及 与其他 ME/CFS 中心的合作； 2）加强JAX ME/CFS之间的沟通与协作 CRC 研究人员以及 ME/CFS 中心和 NIH 代表之间； 3) 发挥社区影响力 指导委员会并参与针对 ME/CFS 患者、医生和患者的教育和外展活动 ME/CFS 研究的新研究者。

PROJECT SUMMARY ADMINISTRATIVE CORE The goal of the Administrative (Admin) Core is to provide management, oversight and logistical support for the proposed JAX Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center (ME/CFS CRC). The Admin Core's role will be to: 1) foster productive scientific interactions within the JAX ME/CFS CRC, which involves 12 investigators at four different locations (JAX, University of Connecticut, North Carolina State University, Bateman Horne Center); 2) maintain alignment of the JAX ME/CFS CRC with ME/CFS Network activities; 3) monitor the progress of research projects, collaborative projects, and cores towards their specific research and resource-sharing goals; 4) ensure efficient data sharing with the ME/CFS Data Management and Coordinating Center (DMCC); 5) coordinate career development and community outreach activities; and 6) administer the solicitation, review, and selection of Collaborative Project proposals. The Admin Core will be led by Center Director Dr. Derya Unutmaz, a highly accomplished immunologist with experience in Center leadership and a deep connection to the ME/CFS community. Dr. Unutmaz recently formed a clinical alliance withthe Bateman Horne Center of Excellence, the clinical partner on this application, to study ME/CFS. Dr. Unutmaz will leverage this connection with the BHC and with the proposed Community Impact Steering Committee as a source of feedback from key stakeholders as well as an outlet for dissemination of ME/CFS research. The Admin Core will leverage the excellent capabilities, facilities and resources offered at JAX for administering large-scale collaborative research projects and educational activities. These resources include support for a full time, institutionally supported Center Administrator, who will assist Dr. Unutmaz by performing many essential Center functions. Together, Dr. Unutmaz and the Center Administrator will effectively execute the following Specific Aims: 1) Optimize integration and function of JAX ME/CFS CRC activities through strong administrative and scientific oversight, including strategic planning, budgetary oversight, conflict resolution, executive decisions on the direction of research activities and collaborations with other ME/CFS Centers; 2) Enhance communication and collaboration among JAX ME/CFS CRC investigators and between ME/CFS centers and NIH representatives; and 3) Convene Community Impact Steering Committee and engage in education and outreach activities for ME/CFS patients, physicians, and investigators new to ME/CFS research.